Abstract: The present invention relates to a method of preparing a topical pharmaceutical composition, a pharmaceutical composition prepared by the method, a topical pharmaceutical composition, and to uses and methods involving the pharmaceutical composition. The pharmaceutical composition comprises at least one local anesthetic agent and a vasoconstrictive agent. The method of preparing the composition comprises stirring an aqueous liquid comprising at least one local anesthetic agent and a vasoconstrictive agent, wherein the stirring is performed substantially without forming a vortex and under an inert gas. The at least one local anesthetic agent may be lignocaine and tetracaine, and the vasoconstrictive agent may be adrenaline.