Patents Assigned to Phenomenex
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Patent number: 10603604Abstract: A slurry chamber is fastened to and held in coaxial alignment with a chromatography column by a V-band. One end of the column has an end cap and frit. A slurry of fluid and chromatographic media is placed in the column and chamber. A piston is forced through the chamber and into the column by a hydraulic ram to expel the fluid and form a media bed in the column. The slurry chamber is removed, and a split end cap is fastened to the column. A threaded recess in the split end cap receives a split, threaded collet. The collet is tightened until it pushes against the piston with the same force as the ram, at which point the ram is released and the column removed for use.Type: GrantFiled: July 19, 2017Date of Patent: March 31, 2020Assignee: Phenomenex, Inc.Inventors: Peter C. Rahn, Romaine R. Maiefski, Tivadar Farkas, Emmet E. Welch
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Publication number: 20140124444Abstract: A chromatography column has an upstream frit made of non-woven, metal fibers sintered to form a depth filter having graded interstitial passages increasing in size in the direction of flow through the column during use. The frit is held in the column or in a recess of an end fitting, insert or PEEK holder. An annular PEEK ring seals at least one face of the frit at a peripheral edge of the frit, and preferably seals both faces at that edge.Type: ApplicationFiled: March 15, 2013Publication date: May 8, 2014Applicant: PHENOMENEX, INC.Inventor: Phenomenex, Inc.
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Patent number: 8658038Abstract: An advanced silica gel sorbent for use in chromatographic separations that has been chemically modified by surface polycondensation of a trifunctional and/or difunctional organosilane. The chromatographic media exhibits a wider pH range and improved pH stability as compared to other silica gel based sorbents, while retaining all other positive aspects attributed to silica gel based sorbents. A method of forming the advanced silica gel sorbent by Templated Multilayer Inorganic/Organic Grafting.Type: GrantFiled: June 30, 2009Date of Patent: February 25, 2014Assignee: Phenomenex, Inc.Inventors: Ismail M. Rustamov, Michael C. Chitty, Tivadar Farkas, Lawrence Loo, Emmet Welch
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Publication number: 20130116597Abstract: A blood sampling device is provided having holder with a manipulating end and an absorbent probe on the opposing end. The probe is of hydrophilic polymer sized to directly absorb a predetermined volume of up to about 30 microliters of blood. Ribs on the holder position the probe within a compartment of a container to prevent contact with the container. The ribs also position the probe within extraction wells.Type: ApplicationFiled: November 2, 2012Publication date: May 9, 2013Applicant: PHENOMENEX, INC.Inventor: PHENOMENEX, INC.
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Patent number: 8062516Abstract: A connector for fastening a gas chromatography capillary column to chromatography equipment includes a securing nut and ferrule on a first portion of the connector for releasably holding the capillary column in a position relative to a second portion of the connector. The first portion rotates relative to the first portion and translates a limited amount relative to the first portion. A pin on the first portion extending into an annular groove around a circumference of the first portion may allow this rotation and limited translation. The second portion has a threaded end adapted to screw into the chromatography equipment with the first portion remaining relatively rotation free as the second portion is screwed into place.Type: GrantFiled: July 9, 2008Date of Patent: November 22, 2011Assignee: Phenomenex, Inc.Inventors: Doug Silva, Jim Archer, Sky Countryman, Kory Kelly
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Publication number: 20100181240Abstract: A slurry chamber is fastened to and held in coaxial alignment with a chromatography column by a V-band. One end of the column has an end cap and frit. A slurry of fluid and chromatographic media is placed in the column and chamber. A piston is forced through the chamber and into the column by a hydraulic ram to expel the fluid and form a media bed in the column. The slurry chamber is removed, and a split end cap is fastened to the column. A threaded recess in the split end cap receives a split, threaded collet. The collet is tightened until it pushes against the piston with the same force as the ram, at which point the ram is released and the column removed for use.Type: ApplicationFiled: January 22, 2010Publication date: July 22, 2010Applicant: Phenomenex, Inc.Inventors: Peter C. Rahn, Romaine R. Maiefski, Tivadar Farkas, Emmet E. Welch
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Publication number: 20100126921Abstract: A slurry chamber is fastened to and held in coaxial alignment with a chromatography column by a V-band. One end of the column has an end cap and fit. A slurry of fluid and chromatographic media is placed in the column and chamber. A piston is forced through the chamber and into the column by a hydraulic ram to expel the fluid and form a media bed in the column. The slurry chamber is removed, and a split end cap is fastened to the column. A threaded recess in the split end cap receives a split, threaded collet. The collet is tightened until it pushes against the piston with the same force as the ram, at which point the ram is released and the column removed for use.Type: ApplicationFiled: February 3, 2010Publication date: May 27, 2010Applicant: Phenomenex, Inc.Inventors: Peter C. Rahn, Romaine R. Maiefski, Tivadar Farkas, Emmet E. Welch
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Patent number: 7674383Abstract: A slurry chamber is fastened to and held in coaxial alignment with a chromatography column by a V-band. One end of the column has an end cap and frit. A slurry of fluid and chromatographic media is placed in the column and chamber. A piston is forced through the chamber and into the column by a hydraulic ram to expel the fluid and form a media bed in the column. The slurry chamber is removed, and a split end cap is fastened to the column. A threaded recess in the split end cap receives a split, threaded collet. The collet is tightened until it pushes against the piston with the same force as the ram, at which point the ram is released and the column removed for use.Type: GrantFiled: October 25, 2005Date of Patent: March 9, 2010Assignee: Phenomenex, Inc.Inventors: Peter C. Rahn, Romaine R. Maiefski, Tivadar Farkas, Emmet E. Welch
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Patent number: 7563367Abstract: An advanced silica gel sorbent for use in chromatographic separations that has been chemically modified by surface polycondensation of a trifunctional and/or difunctional organosilane. The chromatographic media exhibits a wider pH range and improved pH stability as compared to other silica gel based sorbents, while retaining all other positive aspects attributed to silica gel based sorbents. A method of forming the advanced silica gel sorbent by Templated Multilayer Inorganic/Organic Grafting.Type: GrantFiled: September 30, 2005Date of Patent: July 21, 2009Assignee: Phenomenex, Inc.Inventors: Ismail M. Rustamov, Michael C. Chitty, Tivadar Farkas, Lawrence Loo, Emmet Welch
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Patent number: 7119145Abstract: Pre-formed polymer particles are chemically modified by free radical-initiated surface graft modification. The resulting resin is specifically adapted to provide enhanced chromatographic performance throughout chromatographic separations.Type: GrantFiled: January 24, 2003Date of Patent: October 10, 2006Assignee: Phenomenex, Inc.Inventors: Arthur R. Dixon, Emmet E. Welch, Shahana Huq
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Patent number: 6770246Abstract: An improved sorbent cartridge for use in preparing fluid samples by solid phase extraction for chemical analysis is provided that uses a pipette having a longitudinal axis and a tip having walls defining a uniformly tapered interior cavity extending along the axis and opening at a distal end of the tip. A porous barrier is placed in the tapered cavity at a predetermined location in the tip to define a sorbent volume between the barrier, the cavity walls and the opening at the distal end of the tip. The barrier allows processing fluids to pass through the barrier while retaining the sorbent. A slurry of sorbent material is drawn into the sorbent volume by a syringe in fluid communication with the pipette tip. The solvent is drawn through the barrier, filing the sorbent volume with sorbent material. A serum to be analyzed is similarly drawn into the sorbent through the opening in the distal end of the tip, by applying a suction to the tip.Type: GrantFiled: March 3, 2000Date of Patent: August 3, 2004Assignee: Phenomenex, Inc.Inventor: Petr Husek
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Patent number: 6162362Abstract: A cartridge holder includes a holder body having a cavity along a longitudinal axis of the holder body. A floating screw has a longitudinal axis and a hole through the length of the floating screw. The floating screw is adapted to engage with the cavity in such a way that the floating screw is movable relative to the holder body along the longitudinal axis of the holder body. But rotary movement of the floating screw around the longitudinal axis of the holder body is confined by a restriction of the cavity. An outlet unit having a stem with a central hole and a length greater than that of the floating screw is adapted to be movably inserted into the hole of the floating screw, so that a first end of the outlet unit extends out of the hole and a second end of the outlet unit is engaged with the cavity. An end cap is provided to engage with the cavity. In use a cartridge is placed inside the cavity of the holder body between the end cap and the outlet unit.Type: GrantFiled: October 3, 1997Date of Patent: December 19, 2000Assignee: Phenomenex, Inc.Inventors: Qi-Feng Ma, Fred Astani
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Patent number: 5993653Abstract: An alkyl-phenyl bonded a stationary phase for use in reversed-phase liquid chromatography, having five to ten carbon atoms in the alkyl group, is disclosed. The alkyl-phenyl bonded phase has its unique selectivity, and it is chemically stable in both acidic and basic environments as well as having high retention capacity, hence high resolution. A method for preparing the alkyl-phenyl bonded phase and a column inside of which the alkyl-phenyl bonded phase is packed with are also disclosed. Additionally, a method for performing liquid chromatography and a mixed stationary phase which has more than one alkyl-phenyl phases are disclosed.Type: GrantFiled: August 11, 1997Date of Patent: November 30, 1999Assignee: PhenomenexInventors: Faizy Ahmed, Toshihiko Hanai
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Patent number: 5938919Abstract: A protected fused-silica capillary liquid chromatography (liquid chromatography) column is shielded inside a single flexible tubing, which has the same length as the capillary and is integrated with the capillary in the packing process. The column has the advantages of a fused-silica capillary liquid chromatography column combined with the benefits of the shield tubing which makes the column more accurate, durable, and convenient to use, and less expensive to produce.Type: GrantFiled: May 20, 1997Date of Patent: August 17, 1999Assignee: PhenomenexInventor: Bijan Modrek Najafabadi
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Patent number: 5863428Abstract: A new type of guard cartridge has been provided to prevent contamination of liquid chromatography (LC) columns by particulate and soluble contaminants. The cartridge is prepared by packing an empty tube with a chromatographic stationary phase and the packed tube is then sealed on both ends with porus sheets held in place by two collars. The cartridge gives minimum disturbance on column performance and significantly decreases the cost of production.Type: GrantFiled: April 1, 1997Date of Patent: January 26, 1999Assignee: PhenomenexInventors: Qi-Feng Ma, Iraj Aghazade Mohandesi, Fred Astani