Abstract: Provided is a modified bacteriophage capable of infecting a target bacterium, which bacteriophage includes an ?/? small acid-soluble spore protein (SASP) gene encoding a SASP which is toxic to the target bacterium, wherein the SASP gene is under the control of a constitutive promoter which is foreign to the bacteriophage and the SASP gene.
Type:
Grant
Filed:
May 5, 2016
Date of Patent:
October 23, 2018
Assignee:
PHICO THERAPEUTICS
Inventors:
Heather Fairhead, Adam Wilkinson, Sarah Holme, Katy Pitts, Alison Jackson