Abstract: Electrodes for intracorporeal and other uses are provided. The invention features sterilizable, braided electrodes which are formed of or include conductive elements in electronic communication with a plurality of sites for electrical stimulation or sensing. Other active elements may be included in the braided electrodes.
Type:
Application
Filed:
September 8, 2006
Publication date:
April 16, 2009
Applicants:
Drexel University, Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine
Inventors:
Simon Giszter, Frank K. Ko, Ubong Ime Udoekwere, Heejae Yang
Abstract: The invention provides an immunogenic composition comprising MSP-8 linked to an antigen. Methods of using the composition to induce an immune response in an animal are also provided.
Type:
Application
Filed:
February 21, 2008
Publication date:
April 16, 2009
Applicant:
Philadelphia Health & Education Corporation, d/b/a/Drexel University College of Medicine
Abstract: The invention provides isolated liver stage Plasmodium polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-48 and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the liver stage Plasmodium polypeptides of the invention, compositions comprising one or more liver stage Plasmodium polypeptides of the invention, methods for inducing an immune response against the liver stage Plasmodium polypeptides, and methods for treating and diagnosing liver stage malaria.
Type:
Application
Filed:
September 29, 2006
Publication date:
January 15, 2009
Applicants:
SEATTLE BIOMEDICAL RESEARCH INSTITUTE, REED ARMY INSTITUTE OF RESEARCH, PHILADELPHIA HEALTH & EDUCATION CORPORATION, D/B/A/ DREXEL UNIVERSITY COLLEGE OF MEDICINE DUCOM
Inventors:
Patrick Duffy, Stefan H. I. Kappe, Urszula Krzych, Donald G. Heppner, JR., Lawrence W. Bergman, Vladislav A. Malkov, Alice Tarun, Jason W. Wendler, Igor Bacik
Abstract: The invention provides a method of diagnosing a disease or disorder featuring an abnormal level of a ring-containing molecule in a tissue. In one embodiment, a method of diagnosing organ transplant rejection is provided.
Type:
Application
Filed:
April 2, 2008
Publication date:
December 25, 2008
Applicants:
Drexel University, Philadelphia Health & Education Corporation, d/b/a Drexel University College of Medicine
Abstract: A method for local therapies using heat generating implants comprising magnetic or magnetizable features or objects distributed in a solidified moldable matrix to treat bone infection or loosening of implants by the mechanism of hyperthermia or thermoablation.
Type:
Application
Filed:
June 20, 2008
Publication date:
December 25, 2008
Applicant:
Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine
Inventors:
Zachary Graham Forbes, Steven Michael Kurtz
Abstract: Nanotubes loaded with materials, such as active species, and methods to load materials into nanotubes are disclosed. The method includes flowing a medium containing the material to be loaded through the interior volume of the nanotube, wherein it is retained, optionally by a crosslinking or polymerization reaction. Flowing the medium occurs under different conditions and processes, including centrifuging and size exclusion methods.
Type:
Application
Filed:
August 24, 2007
Publication date:
September 11, 2008
Applicant:
Philadelphia Health & Education Corporation, d/b/a Drexel University College of Medicine
Inventors:
Nadarajan S. Babu, Elisabeth S. Papazoglou, Peter D. Katsikis
Abstract: Inventors have developed a chromophore (nitrodibenzylfuranyl, or NBDF) for ultra efficient uncaging of a caged substrate (e.g., an organic molecule such as, for example, an amino acid, a biological molecules, such as, for example, second messengers inside cells). Photolysis of a NBDF derivative of EGTA (i.e. caged calcium) is about 50 times more efficient than others calcium cages (the quantum yield of photolysis is 0.6 and the extinction coefficient is 18,400. NDBF-EGTA has a 2-photon cross section of about 0.3-0.6 GM).
Type:
Application
Filed:
April 12, 2006
Publication date:
August 7, 2008
Applicant:
Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine
Abstract: The invention relates to nucleic acids encoding a mammalian ABCA5 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including, but not limited to, PIN. Further, the invention relates to diagnostic assays for identifying the DNA-binding protein ABCA5 (also known as PIN-1). The invention also relates to oligonucleotide sequence(s) or antibodies that specifically bind with ABCA5 or variants thereof.
Type:
Application
Filed:
September 1, 2006
Publication date:
May 3, 2007
Applicant:
PHILADELPHIA HEALTH & EDUCATION CORPORATION d/b/a Drexel University College of Medicine