Abstract: The invention generally relates systems and methods to for producing an image from a rotational intravascular ultrasound device. A method can include alternately transmitting complementary Golay codes to a plurality of transducers in a intravascular ultrasound device; receiving echoes of the complementary codes from the transducers; performing pulse compression of the echoes that comprises weighting the received echoes and summing an odd number of weighted echoes, wherein a center echo is given a weighted value of 1.0 and weighted sums of its neighbors constitute complementary echoes of a Golay pair; and producing an image from the compressed echoes. A system can include a processor; and a plurality of beam modules coupled to the processor, each module comprising: a receiver for receiving a trigger signal from the processor; a complex programmable logic device programmed with a Golay code; a high voltage switching transmitter; and an ultrasound transducer.

Abstract: Devices, systems, and methods of evaluating a vascular system of a patient, are provided. In some instances, the method includes obtaining external imaging data associated with the heart; obtaining cardiac test data associated with the heart; generating a three-dimensional graphical representation of the heart using the external imaging data and the cardiac test data; and outputting the graphical representation of the heart to a display device, wherein the graphical representation of the heart includes a graphical representation of the cardiac test data. Corresponding systems and devices are also provided.

Abstract: Devices, systems, and methods of evaluating risk associated with a condition of the vessel and issuing an automatic recommendation based on co-registered physiological measurements are disclosed. The includes steps of obtaining image data for the vessel of the patient, obtaining physiological measurements for the vessel of the patient, co-registering the obtained physiological measurements with the obtained image data such that the physiological measurements are associated with corresponding portions of the vessel of the patient, analyzing the co-registered physiology measurements to identify a region of interest, and outputting, to a user interface, a suggested diagnostic procedure for the region of interest based on the analysis of the co-registered physiology measurements.

Abstract: Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to provide FFR measurements in a small, compact device that integrates with existing proximal and distal pressure measurement systems and does not require a separate power source.

Abstract: Intravascular devices, systems, and methods are disclosed. In some embodiments, side-loading electrical connectors for use with intravascular devices are provided. The side-loading electrical connector has at least one electrical contact configured to interface with an electrical connector of the intravascular device. A first connection piece of the side-loading electrical connector is movable relative to a second connection piece between an open position and a closed position, wherein in the open position an elongated opening is formed between the first and second connection pieces to facilitate insertion of the electrical connector between the first and second connection pieces in a direction transverse to a longitudinal axis of the intravascular device and wherein in the closed position the at least one electrical contact is electrically coupled to the at least one electrical connector received between the first and second connection pieces.

Abstract: An imaging device for imaging a portion of a patient's vasculature with an imaging element may include a proximal portion having a relatively higher stiffness that provides rigidity for pushing the imaging device through a patient's vasculature, and may include a distal portion having a relatively lower stiffness that enables threading through a curved vasculature of the patient. The imaging device also may include a transition region disposed between the proximal portion and the distal portion.

Abstract: Sold-state intravascular ultrasound (IVUS) imaging devices, systems, and methods are provided. Some embodiments of the present disclosure are particularly directed to compact and efficient circuit architectures and electrical interfaces for an ultrasound transducer array used in a solid-state IVUS system. In one embodiment, an intravascular ultrasound (IVUS) device includes: a flexible elongate member; an ultrasound scanner assembly disposed at a distal portion of the flexible elongate member, the ultrasound scanner assembly including an ultrasound transducer array; an interface coupler disposed at a proximal portion of the flexible elongate member; and a cable disposed within and extending along a length of the flexible elongate member between the ultrasound scanner assembly and the interface coupler. The cable includes four conductors electrically coupling the ultrasound scanner assembly and the interface coupler.

Abstract: A componentized intravascular ultrasound system is disclosed that flexibly integrates with a catheter lab infrastructure for acquisition and display of intravascular information in a catheter lab environment. The system includes a patient interface module (PIM) adapted to hold a catheter having an imaging probe located near a distal end, a control panel, a monitor for displaying images and patient data, and a processing unit. The processing unit is communicatively coupled to the PIM, the control panel, and the monitor. Furthermore the processing unit adapted to: coordinate operation of the PIM, the control panel, and the monitor; and generate images from image data provides by the PIM. The PIM, control panel and monitor are independently positionable with regard to one another.

Abstract: A method of evaluating a vessel of a patient is provided. The method includes outputting, to a display device, a screen display including: a visualization based on pressure measurements obtained from a first instrument and a second instrument positioned within the vessel of the patient while the second instrument is moved longitudinally through the vessel and the first instrument remains stationary within the vessel; and a visual representation of a vessel; receiving a user input to modify the visualization to simulate a therapeutic procedure; and updating the screen display, in response to the user input, including modifying the visualization based on the user input. A system for evaluating a vessel of a patient is also provided. The system includes first and second instruments sized and shaped for introduction into the vessel of the patient; and a processing system communicatively coupled to the first and second instruments and a display device.

Abstract: Devices, systems, and methods configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel, provide measurements of a vessel that allow assessment of the vessel and, in particular, any stenosis or lesion of the vessel, simulate diagnostic visualizations a first visualization device and a second visualization device. For example, the methods can include displaying, on a first visualization device, an image of the vessel with treatment diagnostic visualizations based on obtained pressure measurements and displaying, on a second visualization device, a portion of the image of the vessel with diagnostic visualizations based on the obtained pressure measurements, wherein the portion of the image of the vessel displayed on the second visualization device is a close up of a region of interest of the vessel.

Abstract: An intravascular ultrasound (IVUS) imaging system is provided. The IVUS imaging system includes an intravascular device including a transducer shaft with an ultrasound transducer at a distal end. The IVUS imaging system also includes an interface module removably coupled to the intravascular device. The interface module includes a connector rotatably coupled to a proximal end of the transducer shaft; a motor coupled to the connector; a spinning element coupled to the motor, wherein the spinning element comprises four conductive rings; a stationary element comprising a plurality of brushes, wherein the stationary element is disposed proximate the spinning element such that a different one of the plurality of brushes is in mechanical contact with each of the four conductive rings; and four conductors coupled to the connector and the spinning element such that the stationary element and the intravascular device are in electrical communication.

Abstract: The invention provides systems and methods for assessing the vasculature of a subject. In certain aspects, systems and methods of the invention involve receiving functional flow data of a subject via a data collector co-located with a radiopaque label, receiving imaging data of the vasculature including the radiopaque label, generating a vasculature map corresponding to the functional flow data, and displaying the vasculature map image on a monitor.

Abstract: Systems and methods for multi-modality data processing are provided. Some embodiments are particularly directed to labeling and indexing multi-modality medical data. In one embodiment, a method for labeling medical data received by a multi-modality medical processing system includes receiving, by the medical processing system, medical data to be labeled. A reference set of labels corresponding to the medical data is presented at a display device. A selection of a first label from the reference set of labels is received from an interface device. A target set of labels corresponding to the medical data is presented at the display device, the target set of labels based on the first label. A selection of a second label from the target set of labels is received from the interface device. The medical data is then labeled based on the first and second labels.

Abstract: Disclosed herein is a non-invasive system for determining tissue composition. The system comprises an imaging system with a non-invasive probe, a signal analyzer, and a correlation processor. The probe includes active imaging components for emitting energy and collecting imaging data including reflected signals from an object of interest. The signal analyzer analyzes the imaging data and determines one or more signal properties from the reflected signals. The correlation processor then associates the one or more signal properties to pre-determined tissue signal properties of different tissue components through a pattern recognition technique wherein the pre-determined tissue signal properties are embodied in a database, and identifies a tissue component of the object based on the pattern recognition technique.

Abstract: Intravascular devices, systems, and methods are disclosed. In some embodiments, the intravascular devices include at least one electronic, optical, or electro-optical component positioned within a distal portion of the device and one or more connectors positioned at a distal portion of the device. In some instances, the connectors are flexible coils, such as a ribbon coil, formed of a conductive material. In some particular instances, the conductive coil is embedded within a polymer tubing. Further, in some embodiments the electronic, optical, or electro-optical component is positioned within a flexible element at the distal portion of the device. In some instances the flexible element is a coil. Methods of making and/or assembling such intravascular devices/systems are also provided.

Abstract: The present invention generally relates to a rapid exchange configuration that reduces the profile of a catheter riding on a guidewire and minimizes guidewire resistance. According to certain embodiments, a body of the catheter includes a distal portion and a proximal portion. The distal portion defines a guidewire lumen and includes a guidewire exit port being open in a proximal direction and leading to the guidewire lumen. A proximal section of the guidewire lumen is straight.

Abstract: The invention provides co-registration systems and methods for detecting endoleaks associated with aneurysm repair. The system includes an imaging device having expanded imaging capabilities and configured to capture and provide image data and flow visualization of a vessel based on the image data. The system further includes one or more sensors for capturing functional parameters of the vessel, such as flow or pressure. The system further includes an external imaging modality for capturing external image data of the vessel, such as, for example, a radiological image. The co-registration system is configured to co-register sets of data captured by a plurality of intra- and extraluminal modalities and provide a composite map (3- or multi-dimensional) of the vessel including automatically detected areas of interest, particularly during an EVAR or TEVAR procedure.

Abstract: Sold-state intravascular ultrasound (IVUS) imaging devices, systems, and methods are provided. Some embodiments of the present disclosure are particularly directed to compact and efficient circuit architectures and electrical interfaces for an ultrasound transducer array used in a solid-state IVUS system. In one embodiment, an intravascular ultrasound (IVUS) device includes: a flexible elongate member; an ultrasound scanner assembly disposed at a distal portion of the flexible elongate member, the ultrasound scanner assembly including an ultrasound transducer array; an interface coupler disposed at a proximal portion of the flexible elongate member; and a cable disposed within and extending along a length of the flexible elongate member between the ultrasound scanner assembly and the interface coupler. The cable includes four conductors electrically coupling the ultrasound scanner assembly and the interface coupler.

Abstract: A rotational intravascular ultrasound probe for insertion into a vasculature and a method of manufacturing the same. The rotational intravascular ultrasound probe comprises an elongate catheter having a flexible body and an elongate transducer shaft disposed within the flexible body. The transducer shaft comprises a proximal end portion, a distal end portion, a drive shaft extending from the proximal end portion to the distal end portion, an ultrasonic transducer disposed near the distal end portion for obtaining a circumferential image through rotation, and a transducer housing molded to the drive shaft and the ultrasonic transducer.

Abstract: Devices, systems, and methods directed to evaluating a vessel of a patient are provided. The method includes outputting, to a display, a screen display including: a visual representation of a pressure ratio of pressure measurements obtained by first and second instruments positioned within a vessel while the second instrument is moved longitudinally through the vessel and the first instrument remains stationary within the vessel; and a visual representation of the vessel; receiving a user input to modify one of the visual representations of the pressure ratio and the vessel to simulate a therapeutic procedure; and updating the screen display, in response to the user input, including: modifying the selected one of the visual representation of the pressure ratio and the vessel based on the received user input; and correspondingly modifying the unselected one of the visual representation of the pressure ratio and the vessel.