Abstract: The present invention provides antibodies, as well as molecules having at least the antigen-binding portion of an antibody, against agonist pro-angiogenic, pro-permeability, vasodilatory isoforms of VEGF. Disclosed antibodies and antibody fragments are characterized by being capable of binding to and neutralizing pro-angiogenic forms of VEGF while not effecting isoforms of VEGF which are anti angiogenic. Methods of production and use in therapy and diagnosis, of such antibodies and antibody fragments are also provided.
Type:
Grant
Filed:
October 26, 2008
Date of Patent:
November 26, 2013
Assignees:
Philogene, Inc., University of Bristol
Inventors:
David O. Bates, Steven J. Harper, Miriam Y. Mengelus, Menachem Ze'evi
Abstract: The present invention provides antibodies, as well as molecules having at least the antigen-binding portion of an antibody, against agonist pro-angiogenic, pro-permeability, vasodilatory isoforms of VEGF. Disclosed antibodies and antibody fragments are characterized by being capable of binding to and neutralizing pro-angiogenic forms of VEGF while not effecting isoforms of VEGF which are anti angiogenic. Methods of production and use in therapy and diagnosis, of such antibodies and antibody fragments are also provided.
Type:
Application
Filed:
October 26, 2008
Publication date:
October 28, 2010
Applicants:
PhiloGene, Inc., University of Bristol
Inventors:
David O. Bates, Steven J. Harper, Miriam Y. Mangelus, Menachem Ze'evi
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