Abstract: Provided herein are eckol derivatives, methods of synthesis thereof and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, Alzheimer's disease, microbial infections, obesity, diabetes, cancer or inflammation using the compounds and pharmaceutical compositions disclosed herein.
Type:
Grant
Filed:
November 9, 2017
Date of Patent:
October 23, 2018
Assignee:
Phloronol, Inc.
Inventors:
Hyeon-Cheol Shin, Hyejeong Hwang, Kwang Yong Park, Seong Ho Kim, Haengwoo Lee
Abstract: Described herein are solid pharmaceutical compositions of brown algae extracts and methods for making solid pharmaceutical compositions of brown algae extracts. In some embodiments, the brown algae extract is derived from Ecklonia cava.
Abstract: Disclosed are a composition for reducing beta amyloid-induced neurotoxicity by inhibiting ?-secretase activity, comprising a dibenzofuran derivative, and a method for preparing the same. Further disclosed is that the combination of the dibenzofuran derivative with a ?-secretase inhibitor or an anti-inflammatory agent shows higher activity with respect to reducing beta amyloid-induced neurotoxicity.
Abstract: Disclosed are a composition for reducing beta amyloid-induced neurotoxicity by inhibiting ?-secretase activity, comprising a dibenzofuran derivative, and a method for preparing the same. Further disclosed is that the combination of the dibenzofuran derivative with a ?-secretase inhibitor or an anti-inflammatory agent shows higher activity with respect to reducing beta amyloid-induced neurotoxicity.
Type:
Application
Filed:
November 17, 2010
Publication date:
May 17, 2012
Applicant:
Phloronol, Inc.
Inventors:
Bong-Ho LEE, Seongho KIM, Hyeon-Cheol SHIN, Haengwoo LEE