Abstract: A meditation surface configured in such a way to facilitate electrically grounded meditation and method of using same for the purpose of restoring harmony and electrical balance of the individual with the earth during meditation, removing electromagnetic field induced body voltage, re-establishing electric contact with the earth, emulating an aspect of ancient teachings of being grounded during meditation activities, while still preserving comfort, cleanliness and shielding from the elements.

Abstract: A continuous process for producing compounds having the general formula (6) is provided: wherein R is a straight or branched chain alkyl group, R1 is a straight or branched chain alkyl group substituted with a nitrile group, a hydroxy group or a halogen atom, R2 is a hydroxy group or a keto group, and each R3 is, independently, hydrogen or a straight or branched chain alkyl group, comprising providing a continuous stream of an alkyl acetate and a continuous stream of an alkali metal or alkaline earth metal amide base and contacting the continuous streams to yield an enolate compound, providing a continuous stream of a compound of formula (5): wherein R1 is as previously defined, and contacting the continuous stream of compound (5) with a continuous stream of the enolate above 20° C. to yield an intermediate compound and treating the intermediate compound with an acid.

Abstract: The present invention is directed to fluoro silicone acrylates that are used in reaction either alone or with other monomers to make polymers that can modify the surface of hair skin or pigment. This makes them ideal for incorporation into pigmented products in personal care applications like make up and lipsticks.

Abstract: The invention provides a process for the manufacture of HI 6 dimethanesulfonate comprising contacting an O-protected pyridine aidoxime compound with bis(methylsulphonoxymethyl)ether in a suitable solvent to form an intermediate compound, contacting said intermediate compound with isonicotinamide to form an O-protected HI 6 product precursor, and de-protecting the precursor to form HI 6 dimethanesulfonate.

Abstract: The present invention concerns a metallocene-based phosphine ligand for use in enantioselective catalysis, the ligand having the Formula (I): Wherein M is a metal; Z is P or As; L is a suitable linker; R1 is selected from alkyl, alkoxy, alkylamino, cycloalkyl, cycloalkoxy, cycloalkylamino carbocyclic aryl, substituted and unsubstituted carbocyclic aryloxy, heteroaryl, heteroaryloxy, carbocyclic arylamino and heteroarylamino; X* is selected from (II): Wherein R, R2 and R3 are independently selected from optionally substituted branched- and straight-chain alkyl, cycloalkyl, heterocycloalkyl, carbocyclic aryl, and heteroaryl.

Abstract: The present invention relates to a continuous process for the cyanation of hydrogenated ?-ketoesters in a cyanation zone maintained under conditions of temperature and pressure effective for cyanation of a hydrogenated R-ketoester. A substrate comprising a hydrogenated ?-ketoester is continuously supplyed to the cyanation zone together with a cyanide. The substrate is contacted with the cyanide in the cyanation zone for a period effective for at least partial cyanation of the hydrogenated ?-ketoester and a product stream is continuously extracted from the cyanation zone.

Abstract: The invention concerns a process for the manufacture of substituted propionic acids comprising providing a substrate of formula (I): And subjecting the substrate to enantioselective hydrogenation under enantioselective hydrogenation conditions in the presence of an enantioselective hydrogenation catalyst comprising a catalyst ligand having a metallocene group with a chiral phosphorus or arsenic substituent to provide in enantiomeric excess a product of formula (II): or its enantiomer or if applicable its diastereomer.

Abstract: The present invention relates to metallocene-based phosphine ligands having chirality at phosphorus and at least one other element of chirality (planar chirality and/or chirality at carbon); and to the use of such ligands in asymmetric transformation reactions to generate high enantiomeric excesses of formed compounds. A method for the preparation of ligands according to the invention involving the conversion of the ortho-lithiated substituted metallocene to a phosphine chiral at phosphorus is also disclosed.

Abstract: The present invention relates to a continuous process for the enantioselective catalytic hydrogenation of ?-ketoesters comprising providing a catalytic hydrogenation zone and maintaining it under conditions of temperature and pressure effective for the catalytic hydrogenation of ?-ketoesters; continuously supplying to the catalytic hydrogenation zone a substrate comprising a ?-ketoester to be hydrogenated, a catalyst effective for enantioselective hydrogenation of the ?-ketoester and hydrogen; contacting the substrate, the catalyst and the hydrogen in the hydrogenation zone for a residence time effective for at least partial enantioselective catalytic hydrogenation of the ?-ketoester; (d) continuously withdrawing from the hydrogenation zone a reaction product mixture comprising enantioselectively hydrogenated ?-ketoester, unreacted ?-ketoester, catalyst and hydrogen; (e) supplying the reaction product mixture to a separation zone and separating at least some of the enantioselectively hydrogenated ?-ketoester

Abstract: A method for the production of diazomethane comprising the steps of a) feeding a base and a diazomethane precursor into a reactor vessel; b) generating gaseous diazomethane by allowing the base and the gaseous diazomethane precursor to react; and c) removing the gaseous diazomethane using a diluent gas.

Abstract: The invention is directed toward a process for conditioning hair and skin, using a silicone polyphosphate that has between 6 and 20 phosphate groups in the molecule. The compounds having multi-phosphate groups have been found to be surprisingly effective conditioners when compared to compounds having fewer or no phosphate groups present.

Abstract: The invention concerns a process for the production of optically active epoxides useful as pharmaceutical intermediates, particularly in the field of HIV protease inhibitors. The optically active epoxides are produced in commercially acceptable yields from an optically active alcohols by a Mitsunobu reaction and a cyclisation step, preferably comprising an intermediate re-crystallisation step. The stereochemistry of the alcohol is inverted during the Mitsunobu reaction to produce the desired epoxide.

Abstract: The present invention relates to a series of novel silicone phosphate esters which mitigate eye and skin irritation when used in synergistic combinations with fatty alcohol sulfates and fatty alcohol ether sulfates. These materials form complexes which have surprisingly low irritation properties.

Abstract: The present invention relates to a series of novel silicone isethionate polymers, useful as detergents and softeners for hair, and fiber and conditioners skin. The compounds of the present invention are prepared by the reaction of a carboxy silicone with an isethionate to produce novel surface active materials useful in personal care applications like soap bars.

Abstract: The present invention relates to a series of novel amido silicone functional taurine derivatives, useful in softening hair, and fiber and conditioning skin. The compounds of the present invention are prepared by the reaction of a carboxy silicone with a taurine derivative to produce novel surface active materials useful in personal care applications like soap bars.

Abstract: The present invention relates to a series of novel taurine functional silicone polymers, useful in softening hair, and fiber and conditioning skin.Since the compounds of the present invention are high molecular weight silicone polymers, they have a high degree of oxidative stability, even at elevated temperatures.The compounds of the present invention are prepared by the reaction of chloro silicone intermediate with a taurine derivative. In a preferred embodiment the hydroxy containing silicone polymer has been alkoxylated with ethylene oxide, propylene oxide or mixtures thereof. The ability regulate the type of alkylene oxide and amount present in the silicone polymer results in a series of products ranging in water/oil solubility. The technology used to produce the compounds of the present invention is very flexible and allows us to prepare performance tailored molecules for specific applications.

Abstract: Piperidine-4-carboxylic acid derivatives of the formula ##STR1## wherein: R.sub.2 is hydrogen, alkyl having from one to four carbon atoms, or oxyl;R.sub.3 is --XR.sub.5 or --CN;R.sub.4 is alkylene having from two to twelve carbon atoms; cycloalkylene having from three to twelve carbon atoms; arylene having from six to twelve carbon atoms; or aralkylene having from seven to twelve carbon atoms;R.sub.5 is hydrogen, alkyl having from one to twenty carbon atoms, cycloalkyl having from five to six carbon atoms; or alkenyl having from three to twenty carbon atoms; or ##STR2## X is --O-- or --NH--; and n is 0 to 10;and the acid addition salts thereof.

Abstract: 1,3-Dicarbonyl compounds are provided having the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are defined in the description as well as metal and organotin enolate salts thereof.The compounds are effective in enhancing the resistance to deterioration by heat and light of polyvinyl halide resins.

Abstract: Stabilizer compositions and polyvinyl halide resin compositions containing 1,3-dicarbonyl compounds having the formula: ##STR1## as well as metal and organotin enolate salts thereof, effective in enhancing the resistance to deterioration by heat and light of polyvinyl halide resins.