Abstract: The present invention provides novel expression systems for producing desired polypeptides in certain strains of yeast. The present invention further provides methods for producing polypeptide products using such expression systems. The present invention also provides compositions relating to the same.
Abstract: The present invention discloses arginine deiminase that is genetically modified for more efficient manufacturing and processing. The present invention discloses recombinant DNA molecules and vectors and other therapeutic and pharmaceutical compositions. The present invention also discloses methods for preparing modified arginine deiminase as well as methods of treating cancer and other disease states using modified arginine deiminase.
Type:
Grant
Filed:
May 4, 2000
Date of Patent:
October 21, 2003
Assignee:
Phoenix Pharmacologies, Inc.
Inventors:
Charles Mark Ensor, Frederick Wayne Holtsberg, Mike A. Clark