Abstract: A method of compensating for differences in detective gain between a plurality of different scanning heads in a multiple scanning head imaging plate scanner, comprising: (a) scanning each of the scanning heads across an imaging plate thereby determining the detected signal at successive locations across the imaging plate for each of the scanning heads; (b) calculating an inverse relationship to the detected signal at successive locations across the imaging plate for each of the scanning heads; (c) scanning each of the scanning heads across an imaging plate containing an image thereon, thereby determining an image value at the successive locations across the imaging plate for each of the scanning heads; and (d) applying the inverse relationship to the determined image values at the successive locations across the imaging plate for each of the scanning heads.