Abstract: The invention provides a compound comprising a photosensitizing agent coupled to a carrier molecule with a minimum coupling ratio of 3:1 wherein the carrier molecule has a binding specificity for a target cell. There is also provided a process of conjugation comprising the use of a first and second aprotic solvent and uses of the conjugated compounds.

Abstract: The present invention relates to a polypeptide comprising at least one alpha-helix having synthetically attached thereto a plurality of therapeutic or diagnostic moieties, wherein said therapeutic or diagnostic moieties may be the same or different and are spatially oriented on the polypeptide so as to minimise interactions between said moieties. Further aspects of the invention relate to a pharmaceutical composition comprising the polypeptide; a polynucleotide sequence encoding the polypeptide; an expression vector comprising said polynucleotide sequence; and a host cell transformed with said expression vector. The invention also provides a method of treatment comprising administering to a subject in need thereof a therapeutically effective amount of said polypeptide.

Abstract: FR1 ?????????1?????????2?????????3 H1-H2 Locus 123456789012345678901234567890 VH1 1-3 1-02 QVQLVQSGAEVKKPGASVKVSCKASGYTFT 1-3 1-03 QVQLVQSGAEVKKPGASVKVSCKASGYTFT 1-3 1-08 QVQLVQSGAEVKKPGASVKVSCKASGYTFT 1-2 1-18 QVQLVQSGAEVKKPGASVKVSCKASGYTFT 1-U 1-24 QVQLVQSGAEVKKPGASVKVSCKVSGYTLT 1-3 1-45 QMQLVQSGAEVKKTGSSVKVSCKASGYTFT 1-3 1-46 QVQLVQSGAEVKKPGASVKVSCKASGYTFT 1-3 1-58 QMQLVQSGPEVKKPGTSVKVSCKASGFTFT 1-2 1-69 QVQLVQSGAEVKKPGSSVKVSCKASGGTFS 1-2 1-e QVQLVQSGAEVKKPGSSVKVSCKASGGTFS 1-2 1-f EVQLVQSGAEVKKPGATVKISCKVSGYTFT VH2 3-1/2-1 2-05 QITLKESGPTLVKPTQTLTLTCTFSGFSLS 3-1 2-26 QVTLKESGPVLVKPTETLTLTCTVSGFSLS 3-1 2-70 QVTLKESGPALVKPTQTLTLTCTFSCFSLS VH3 1-3 3-07 EVQLVESGGGLVQPGGSLRLSCAASGFTFS 1-3 3-09 EVQLVESGGGLVQPGRSLRLSCAASGFTFD 1-3 3-11 QVQLVESGGGLVKPGGSLRLSCAASGFTFS 1-1 3-13 EVQLVESGGSLVQPGGSLRLSCAASGFTFS 1-U 3-15 EVQLVESGGGLVKPGGSLRLSCAASGFT