Patents Assigned to PhotoCure AS
  • Photochemotherapeutic compositions
    Patent number: 6750212
    Abstract: The invention provides pharmaceutical compositions comprising a protoporphyrin precursor photochemotherapeutic agent together with vascular stroma-localizing photosensitizers, optionally together with at least one surface penetration assisting agent and optionally with one or more chelating agents, and use of the same in treating disorders or abnormalities which are responsive to PDT, preferably exhibiting synergistically enhanced therapy, kits comprising same and methods of therapy and diagnosis.
    Type: Grant
    Filed: July 9, 1999
    Date of Patent: June 15, 2004
    Assignee: PhotoCure AS
    Inventors: Qian Peng, Jahn M. Nesland, Karl E. Giercksky, Johan Moan, Trond Warloe
  • Transfer of molecules into the cytosol of cells
    Patent number: 6680301
    Abstract: The present invention relates to a method for introducing molecules in cells by disrupting endosomal and lysosomal membranes using photodynamic treatment, without killing the majority of the cells by the photodynamic treatment. More particularly, this invention includes a method for transferring DNA and/or RNA, such as genes, to cells by photochemically inducing the disruption of endosomes and lysosomes.
    Type: Grant
    Filed: September 1, 1998
    Date of Patent: January 20, 2004
    Assignee: Photocure AS
    Inventors: Kristian Berg, Kirsten Sandvik, Johan Moan, Anders Høgset
  • Transfer of molecules into the cytosol of cells
    Publication number: 20030134813
    Abstract: The present invention relates to a method for introducing molecules in cells by disrupting endosomal and lysosomal membranes using photodynamic treatment, without killing the majority of the cells by the photodynamic treatment. More particularly, this invention includes a method for transferring DNA and/or RNA, such as genes, to cells by photochemically inducing the disruption of endosomes and lysosomes.
    Type: Application
    Filed: November 1, 2002
    Publication date: July 17, 2003
    Applicant: Photocure AS
    Inventors: Kristian Berg, Kirsten Sandvik, Johan Moan, Anders Hogset
  • Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
    Patent number: 6492420
    Abstract: The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: December 10, 2002
    Assignee: PhotoCure AS
    Inventors: Karl E. Gierskcky, Johan Moan, Qian Peng, Harald Steen, Trond Warloe, Alf Bjorseth
  • Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
    Patent number: 6034267
    Abstract: The invention provides a pharmaceutical compositions comprising a compound of formula I:R.sub.2.sup.2 N--CH.sub.2 COCH.sub.2 --CH.sub.2 CO--OR.sup.1(I)wherein, R.sup.1 and R.sup.2 have any of the values defined in the specification; or a salt thereof; and a pharmaceutically acceptable carrier or excipient. The invention also provides a method for the diagnosis or photochemotherapeutic treatment of disorders or abnormalities of external or internal surfaces of the body using such compounds or salts.
    Type: Grant
    Filed: December 5, 1997
    Date of Patent: March 7, 2000
    Assignee: PhotoCure AS
    Inventors: Karl E. Gierskcky, Johan Moan, Qian Peng, Harald Steen, Trond Warloe, Alf Bjorseth
  • Transfer of molecules into the cytosol of cells
    Patent number: 5876989
    Abstract: A method for releasing molecules into the cytosol of cells without killing the majority of the cells by allowing the molecules to be taken up in endosomes, lysosomes or other cell compartments and use light activation of photosensitizing compounds to rupture the membranes of the endosomes, lysosomes or other cell compartments, is described.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: March 2, 1999
    Assignee: Photocure AS
    Inventors: Kristian Berg, Kirsten Sandvig, Johan Moan