Abstract: Compounds including a tetrapyrrolic or reduced tetrapyrrolic group/moiety and an epidermal growth factor receptor targeting group are disclosed. For example, a compound includes a tetrapyrrolic or reduced tetrapyrrolic group or moiety, a linker moiety, an epidermal growth factor receptor targeting group, and, optionally, a PET-active functional group. Uses of the compounds, for example, methods of treating a hyperproliferative tissue in an individual, and kits including one or more of the compounds are also provided.
Type:
Grant
Filed:
December 13, 2017
Date of Patent:
August 10, 2021
Assignees:
Health Research, Inc., Photolitec, LLC
Inventors:
Ravindra K. Pandey, Heinz Baumann, Khurshid Guru, Ravindra Cheruku, Erin Tracy, Farukh Durrani, Joseph Cacaccio, Kevin Siters
Abstract: A tetrapyrrolic photosensitizer and imaging compound having a substituent other than hydrogen at its 10 carbon atom which substituent may contain a PAA nanoparticle.
Abstract: A tetrapyrrolic photosensitizer and imaging compound having a substituent other than hydrogen at its 10 carbon atom which substituent may contain a PAA nanoparticle.