Abstract: The present invention provides synchronization and control between the wavelength of a multi-wavelength illuminator and the image frames acquired by a video camera. In accordance with the present invention, the trailing edge of a camera expose-signal triggers a pre-loaded digital value to be output from a FIFO buffer. The digital value selects a particular illumination wavelength either directly or through a voltage from a digital to analog converter. The FIFO may be periodically refilled, or it may be a circular register.

Abstract: The present invention provides a control interface for one or more instruments that comprise an image acquisition system, the control interface consisting of kinesthetic controls that do not require visual attention. The control interface of the present invention maps kinesthetic controls such as sliders and knobs to a system computer and software running thereon which is directing the operation of individual imaging instruments.

Abstract: The invention comprises a real-time stroboscopic acquisition protocol for a measurement of the fluorescence decay and a method and apparatus for real-time calculation of the fluorescence lifetime from that measurement.

Abstract: The invention comprises a real-time stroboscopic acquisition protocol for a measurement of the fluorescence decay and a method and apparatus for real-time calculation of the fluorescence lifetime from that measurement.

Abstract: The present invention provides a control interface for one or more instruments that comprise an image acquisition system, the control interface consisting of kinesthetic controls that do not require visual attention. The control interface of the present invention maps kinesthetic controls such as sliders and knobs to a system computer and software running thereon which is directing the operation of individual imaging instruments.

Abstract: The present invention provides synchronization and control between the wavelength of a multi-wavelength illuminator and the image frames acquired by a video camera. In accordance with the present invention, the trailing edge of a camera expose-signal triggers a pre-loaded digital value to be output from a FIFO buffer. The digital value selects a particular illumination wavelength either directly or through a voltage from a digital to analog converter. The FIFO may be periodically refilled, or it may be a circular register.

Abstract: A random wavelength access monochromator incorporates a pair of coaxial off-axis parabolic reflectors configured so that the spherical aberrations introduced by the reflectors cancel each other. Light enters through an entrance slit and impinges upon a first off-axis parabolic reflector that collimates the beam and directs it towards a stationary grating. The grating in turn defracts the light and directs it towards a high speed scanning mirror which reflects the defracted light onto a second off-axis parabolic reflector which in turn focuses the beam to an exit slit. Both off-axis parabolic surfaces share the same axis of revolution and the same collimated beam axis. In order to make the apparatus practical, the beam is folded twice so that the exit point is focused away from the internal path of the beam.

Abstract: A dual wavelength spectrophotometer produces a relatively small, high power, high duty cycle light spot from a single relatively low power multi-chromatic light source. A Xenon arc lamp light source is focused by an ellipsoidal mirror onto a rotating partially reflective optical chopper. The chopper comprises a wheel having mirrored segments alternately separated by transparent segments. Light reflected by the mirrored segments passes through a first monochromator which produces a first monochromatic light beam. Light transmitted through the transparent segments passes through a second monochromator and emerges as a second monochromatic light beam having a wavelength different from the wavelength of said first monochromatic light beam. The first and second monochromatic light beams are recombined into a single dual wavelength light beam that is reflected through a sample to be analyzed. Reflective front surfaces are employed throughout the system in order to minimize power loss.