Abstract: A system and method for identifying a post cecum position of an ingestible, phototherapeutic capsule traveling through a gastrointestinal (GI) tract to prevent intestinal blockage and facilitating deployment of additional phototherapeutic capsules in accordance with patient needs. The system employs an ex-vitro beacon in wireless communication with the capsule. The ex-vitro beacon is deployed in the vicinity of the McBurney's point to direct a beacon signal toward the cecum to identify capsule passage into the large intestine less prone to blockage.

Abstract: Provided is a swallowable capsule for providing phototherapy to a patient's gastrointestinal (GI) tract, the capsule including a power supply, one or more phototherapeutic light sources, a speed determination unit for calculating speed of movement of the capsule in the GI tract, and a controller unit for activating one or more of the one or more light sources for delivering a therapeutic illumination dose to a target site in the GI tract, based, at least in part, on a determined speed. Related apparatus and methods are also described.

Abstract: The present disclosure generally provides systems and methods for manipulating bacterial growth, abundance and diversity in biological sample. More particularly, the present invention relates to systems and methods for manipulating gut microbiota.

Abstract: Provided is a swallowable capsule for providing phototherapy to a patient's gastrointestinal (GI) tract, the capsule including a power supply, one or more phototherapeutic light sources, a speed determination unit for calculating speed of movement of the capsule in the GI tract, and a controller unit for activating one or more of the one or more light sources for delivering a therapeutic illumination dose to a target site in the GI tract, based, at least in part, on a determined speed. Related apparatus and methods are also described.

Abstract: A swallowable capsule for providing phototherapy to a patient's gastrointestinal (GI) tract, the capsule including a power supply, one or more phototherapeutic light sources, a speed determination unit for calculating speed of movement of the capsule in the GI tract, and a controller unit for activating one or more of the one or more light sources for delivering a therapeutic illumination dose to a target site in the GI tract, based, at least in part, on a determined speed. Related apparatus and methods are also described.

Abstract: A method for providing phototherapy to a GI tract including using a capsule imager to scan at least a portion of a GI tract, estimating a location of a diseased portion of the GI tract, and based, at least in part, on the estimated location, using a phototherapy capsule to provide phototherapeutic light to the diseased portion. A swallowable capsule for providing phototherapy to a GI tract including a power supply, a camera unit, one or more light sources emitting in a range including visible and Near Infra Red (NIR), and a control unit for calculating an effective dose to the GI tract by controlling the one or more light sources, a communication unit for transmitting images from the camera unit to an out-of-body receiver and for receiving control commands from an out-of-body transmitter. Related apparatus and methods are also described.

Abstract: A swallowable capsule for providing phototherapy to a patient's gastrointestinal (GI) tract, the capsule including a power supply, one or more phototherapeutic light sources, a speed determination unit for calculating speed of movement of the capsule in the GI tract, and a controller unit for activating one or more of the one or more light sources for delivering a therapeutic illumination dose to a target site in the GI tract, based, at least in part, on a determined speed. Related apparatus and methods are also described.

Abstract: The present invention provides a swallowable capsule suitable for providing phototherapy to a region of a patient's gastrointestinal (GI) tract, the capsule comprising one or more light sources emitting in the visible and/or NIR ranges and optical elements for shaping the light beam produced by said light sources, such that said light source(s) and said optical elements are capable of delivering an effective therapeutic dose to a target site within the GI tract. The present invention further provides a method for intraluminal phototherapy of the gastrointestinal tract using a swallowable capsule as described hereinabove.

Abstract: A phototherapeutic system for providing phototherapy to a patient's lower parts of a gastrointestinal (GI) tract, the phototherapeutic system including a capsule sized and shaped for insertion into the rectum, the capsule including one or more phototherapeutic light sources. A method for intra-luminal phototherapy of the lower parts of the gastrointestinal (GI) tract including inserting a phototherapeutic device including one or more phototherapeutic light sources into the rectum, activating the light sources, and providing light at a dose suitable for providing a phototherapeutic effect. Related apparatus and methods are also described.