Patents Assigned to Phrixus Pharmaceuticals, Inc.
  • Treatment of chronic progressive heart failure
    Patent number: 9155758
    Abstract: The invention provides a method for treating or preventing heart failure in a subject, which includes administering to the subject in need thereof a therapeutically effective amount of a Poloxamer (e.g., Poloxamer 188).
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: October 13, 2015
    Assignee: PHRIXUS PHARMACEUTICALS, INC.
    Inventor: Bruce Edward Markham
  • Compositions and methods for treating and preventing skeletal muscle deficiencies
    Patent number: 9107940
    Abstract: The present invention relates to compositions and methods for treating and preventing skeletal muscle deficiencies. In particular, the present invention provides compositions comprising poloxamers (e.g., poloxamer 188-P188) and methods of using the same for treating and preventing skeletal muscle deficiencies and injuries (e.g., dystrophin-deficient skeletal muscle; skeletal muscle having a contraction force deficit; skeletal muscle having a Ca2+ imbalance; skeletal muscle having microtears).
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: August 18, 2015
    Assignees: The Regents of the University of Michigan, Phrixus Pharmaceuticals, Inc.
    Inventors: Rainer Ng, Joseph M. Metzger, Lorraine Reeve, Bruce Markham
  • Compositions and methods for treating and preventing skeletal muscle deficiencies
    Patent number: 8852568
    Abstract: The present invention relates to compositions and methods for treating and preventing skeletal muscle deficiencies. In particular, the present invention provides compositions comprising poloxamers (e.g., poloxamer 188-P188) and methods of using the same for treating and preventing skeletal muscle deficiencies and injuries (e.g., dystrophin-deficient skeletal muscle; skeletal muscle having a contraction force deficit; skeletal muscle having a Ca2+ imbalance; skeletal muscle having microtears).
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: October 7, 2014
    Assignees: The Regents of the University of Michigan, Phrixus Pharmaceuticals, Inc.
    Inventors: Rainer Ng, Joseph M. Metzger, Lorraine Reeve, Bruce Markham
  • Compositions and Methods for the Treatment of Heart Failure
    Publication number: 20130129662
    Abstract: The invention provides a therapeutic composition comprising an aqueous buffer, and a therapeutic agent that proves the functioning of a diseased heart by decreasing left ventricular end-diastolic pressure and simultaneously increasing left ventricular ejection without affecting the blood pressure or heart rate.
    Type: Application
    Filed: December 13, 2012
    Publication date: May 23, 2013
    Applicant: Phrixus Pharmaceuticals, Inc.
    Inventor: Phrixus Pharmaceuticals, Inc.
  • Compositions and methods for the treatment of heart failure
    Patent number: 8372387
    Abstract: The invention provides a therapeutic composition comprising an aqueous buffer, and a therapeutic agent that improves the functioning of a diseased heart by decreasing left ventricular end-diastolic pressure and simultaneously increasing left ventricular ejection without affecting the blood pressure or heart rate.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: February 12, 2013
    Assignee: Phrixus Pharmaceuticals, Inc.
    Inventor: Bruce Edward Markham
  • COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING SKELETAL MUSCLE DEFICIENCIES
    Publication number: 20110033412
    Abstract: The present invention relates to compositions and methods for treating and preventing skeletal muscle deficiencies. In particular, the present invention provides compositions comprising poloxamers (e.g., poloxamer 188-P188) and methods of using the same for treating and preventing skeletal muscle deficiencies and injuries (e.g., dystrophin-deficient skeletal muscle; skeletal muscle having a contraction force deficit; skeletal muscle having a Ca2+ imbalance; skeletal muscle having microtears).
    Type: Application
    Filed: December 17, 2008
    Publication date: February 10, 2011
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, PHRIXUS PHARMACEUTICALS, INC.
    Inventors: Rainer Ng, Joseph M. Metzger, Lorraine Reeve, Bruce Markham
  • Compositions and Methods for the Treatment of Heart Failure
    Publication number: 20100178269
    Abstract: The invention provides a therapeutic composition comprising an aqueous buffer, and a therapeutic agent that improves the functioning of a diseased heart by decreasing left ventricular end-diastolic pressure and simultaneously increasing left ventricular ejection without affecting the blood pressure or heart rate.
    Type: Application
    Filed: April 4, 2008
    Publication date: July 15, 2010
    Applicant: Phrixus Pharmaceuticals , Inc.
    Inventor: Bruce Edward Markham