Abstract: A heart treatment system is disclosed capable of guiding a device towards one or more critical regions of interest by sensing signals from tissue. If a critical region is not present at the current location of sensed signals, the system is capable of indicating a guidance direction in which to navigate to reach one or more critical regions. When stopping rules for direction are met, treatment can be applied to said region of interest by thermal or non-thermal energy delivery. Signals are again sensed and analyzed to assess the impact of treatment. This process is repeated until all critical regions of interest are treated. In some embodiments, all functionality is provided by a single sensing and treating device coupled with a display device and analytical software.

Abstract: A novel catheter is disclosed comprising an electrode array that is capable of switching between a sensing configuration for sensing electrical signals of biological tissue and an ablation configuration for delivery of ablation energy at a region of interest. Irrigation ports are interlaced within the electrode array to vent irrigant during an ablation procedure to; prevent excessive heating, charring of tissue, coagulation of blood, and allow for efficient delivery of ablation therapy for maximum therapy efficacy. The novel catheter includes a plurality of splines with linear portions wherein the electrodes of the electrode array are disposed. The splines are connected by connectors which include one or more bends capable of storing potential energy when the bends are elastically deformed, enabling collapse and expansion of the catheter in a sheath.

Abstract: An ablation treatment catheter may include a first conductive wire formed of a first material. The first conductive wire is configured to be connected to a power generator and to carry a current to deliver ablation energy to a biological tissue. The catheter may include a second wire coupled to the first conductive wire. The second wire formed of a second material. The second wire forming a junction with the first conductive wire. The catheter may include a first electrode comprising an ablation element and a temperature sensor. The ablation element includes part of the first conductive wire and is configured to deliver the ablation energy to the biological tissue. The temperature sensor includes the junction of the first conductive wire and the second wire such that a thermocouple is formed at the junction to measure temperature at the first electrode.

Abstract: Disclosed includes a body surface device for diagnosing locations associated with electrical rhythm disorders to guide therapy. The device can sense electrical signals and determine multiple sites that may be operative in that patient. The patch may encompass the heart regions from where the heart rhythm disorder originates. The patch comprises an array of electrodes configured to detect electrical signals generated by a heart. A controller may determine the locations of interest based on detected electrical signals. The controller is configured to locate these regions relative to the surface patch. The system may be coupled to a sensor or therapy device inside the heart, to guide this device to a region of interest. The controller is further configured to instruct the operator to use the trigger or source information to treat the heart rhythm disorder in an individual using additional clinical data and methods for personalization such as machine learning.

Abstract: A heart treatment system is disclosed capable of diagnosing one or more critical regions of interest for a biological rhythm disorder by sensing signals from biological tissue. If a critical region is not present at the current location of sensed signals, the system is capable of indicating a guidance direction in which to navigate to reach one or more critical regions. Ablation energy is delivered to treat said region of interest. Signals are again sensed and analyzed to assess the impact of treatment. This process is repeated until all critical regions of interest are treated. In some embodiments, all functionality is provided by a single sensing and treating catheter with display device and analytical software.

Abstract: Disclosed includes a body surface device for diagnosing locations associated with electrical rhythm disorders to guide therapy. The device can sense electrical signals and determine multiple sites that may be operative in that patient. The patch may encompass the heart regions from where the heart rhythm disorder originates. The patch comprises an array of electrodes configured to detect electrical signals generated by a heart. A controller may determine the locations of interest based on detected electrical signals. The controller is configured to locate these regions relative to the surface patch. The system may be coupled to a sensor or therapy device inside the heart, to guide this device to a region of interest. The controller is further configured to instruct the operator to use the trigger or source information to treat the heart rhythm disorder in an individual using additional clinical data and methods for personalization such as machine learning.