Abstract: The present invention relates to a novel bacterial strain isolated from groundwater. The invention also relates to bacterial extracts and to the use of same in the context of the treatment of inflammations. More particularly, the present invention relates to novel compositions of interest in the treatment and the prevention of inflammatory disorders, notably dermatological pathologies.
Type:
Grant
Filed:
February 19, 2015
Date of Patent:
May 30, 2017
Assignees:
PIERRE FABRE DERMO-COSMETIQUE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: The invention relates to a ternary lipid association of ?-sitosterol, isocetyl stearoyl stearate and glyceryl tri-2-ethylhexanoate, wherein the ?-sitosterol content of said association is between 0.1% and 5 wt. %.
Type:
Grant
Filed:
July 11, 2014
Date of Patent:
April 11, 2017
Assignees:
PIERRE FABRE DERMO-COSMETIQUE, UNIVERSITE PARIS-SUD 11, CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
Inventors:
Hélène Duplan, Daniel Redoules, Alexandre Delalleau
Abstract: The invention relates to an association comprising a peptide containing the sequence A-Lys-Gly-His-Lys-NH2, wherein A is the radical corresponding to a C1 to C18 saturated or unsaturated fatty acid, and glyceryl laurate or one of the derivatives thereof. The invention also relates to the use thereof for stimulating hair growth.
Abstract: The present invention relates to a combination comprising a hyaluronic acid or a salt thereof and a sulphated polysaccharide of which the molecular weight is between 5 and 25 kDa, which is of use in particular for combating the signs of skin ageing or for treating and healing skin wounds.
Type:
Application
Filed:
April 30, 2015
Publication date:
February 23, 2017
Applicant:
PIERRE FABRE DERMO-COSMETIQUE
Inventors:
Stéphane POIGNY, Hélène HERNANDEZ-PIGEON, Jean-Hilaire SAURAT, Gürkan KAYA
Abstract: The present invention relates to the activation of peptidyl arginine deiminase (PADs) 1 and/or 3 in the epidermis by at least one active agent used alone or in combination, namely caffeine, acefylline and/or theobromine in a cosmetic and/or pharmaceutical composition. The present invention also relates to the use of the aforementioned active agents in cosmetics and/or therapeutics, alone or in combination, in order to improve the barrier functions of the epidermis, to prevent and/or treat symptoms related to dry skin or to improve and/or promote hydration of the keratinous layer. Finally, the invention relates to increasing the activity of PAD1 and/or PAD3 in the epidermis.
Type:
Grant
Filed:
April 11, 2012
Date of Patent:
February 14, 2017
Assignee:
PIERRE FABRE DERMO-COSMETIQUE
Inventors:
Hélène Duplan, Sylvie Daunes-Marion, Stéphane Poigny, Marie-Claire Mechin, Guy Serre, Michel Simon
Abstract: The invention relates to a sucrose octasulfate of magnesium, having general formula I, the preparation method thereof and the use of same in the pharmaceutical and/or cosmetic field, wherein 0?n?4, n is an integer and Y represents OH, Cl, Br, I, NO3, C6H5O7, CH3CO2, CF3CO2 or —OCH3.
Abstract: The present invention relates to a compound of general formula (I) in which: —R1 and R2 are simultaneously or independently H, OH, OCH3 or a C1-C5 alkyl radical, —R3 and R4 are simultaneously CH3, —or R3 is H and R4 is CH3, CH2CH3 or an isopropyl radical or a phenyl radical, —R5 is a C4-C24 alkyl radical or a 3-phenylpropanyl or 2,2-diphenylethanyl radical.
Abstract: The present invention relates to L-glutamate-derived compounds of general formula (I) in which the R radical is a linear or branched C5 to C2 alkyl group, .—or the benzyl radical, .—or the phenethyl radical, for topical use as a medicament (or as a dermatological active ingredient) intended for the treatment and/or prevention of inflammatory dermatoses.
Type:
Grant
Filed:
December 19, 2013
Date of Patent:
November 15, 2016
Assignee:
PIERRE FABRE DERMO-COSMETIQUE
Inventors:
Daniel Redoules, Sylvie Daunes-Marion, Stéphane Poigny, Marie-Françoise Aries
Abstract: The present invention relates to a novel bacterial strain isolated and characterized from groundwater. The invention also relates to bacterial extracts and to the therapeutic use of same, notably in the context of the treatment of inflammations.
Type:
Grant
Filed:
December 22, 2011
Date of Patent:
November 8, 2016
Assignees:
PIERRE FABRE DERMO-COSMETIQUE, PIERRE FABRE MEDICAMENT
Abstract: The present invention concerns a combination comprising the dipeptide L-alanyl-L-glutamine, hyaluronic acid or one of the salts of same and an oat extract, advantageously intended for healing wounds and repairing skin lesions.
Abstract: A method for high temperature sterilization of an emulsion, in particular a dermocosmetic preparation. The method comprises the steps of gradually pre-heating, performing ultra-high temperature sterilization and gradually cooling the emulsion. The emulsion is heated up to a pre-heating temperature, which is the temperature of the emulsion at the stability limit. Ultra-high temperature sterilization is performed by infusion of the pre-heated emulsion by heating the emulsion up to a sterilization temperature, maintaining the emulsion at the sterilization temperature, and cooling the emulsion under a vacuum at an end-of-sterilization temperature. The emulsion is gradually cooled with agitation to a storage temperature.
Abstract: The present invention relates to a process for obtaining a juice of fresh plants, characterized in that said fresh plants, with the exclusion of the seeds only, are subjected to a thermomechanical treatment consisting in extruding the fresh plants in an extruder, combined with a heat treatment which makes it possible to inactivate the endogenous enzymes and to preserve the molecules of compounds of interest in the native form thereof, in the absence of solvent, followed by a juice recovery operation.
Type:
Application
Filed:
September 18, 2014
Publication date:
August 25, 2016
Applicants:
PIERRE FABRE DERMO-COSMETIQUE, PIERRE FABRE MEDICAMENT
Abstract: The invention relates to a compound of general formula (I) characterized in that: R1 is a C1-C4 alkyl group, and R2 is an optionally substituted nitrogen, sulfur or oxygen containing heteroaromatic ring.
Abstract: The invention concerns topical compositions based on retinaldehyde, glycylglycine oleamide and, if necessary, delta-tocopheryl-glucopyranoside, and their use in cosmetology and dermatology to combat skin ageing and more particularly light-induced skin ageing.
Type:
Application
Filed:
June 3, 2014
Publication date:
July 21, 2016
Applicant:
PIERRE FABRE DERMO-COSMETIQUE
Inventors:
Daniel BACQUEVILLE, Patrick BOGDANOWICZ, Jean-Hilaire SAURAT, Olivier SORG
Abstract: The invention relates to a ternary lipid association of ?-sitosterol, isocetyl stearoyl stearate and glyceryl tri-2-ethylhexanoate, wherein the ?-sitosterol content of said association is between 0.1% and 5 wt. %.
Type:
Application
Filed:
July 11, 2014
Publication date:
June 16, 2016
Applicants:
PIERRE FABRE DERMO-COSMETIQUE, UNIVERSITE PARIS-SUD 11, CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
Inventors:
Hélène DUPLAN, Daniel REDDULES, Alexandre DELALLEAU
Abstract: The present invention relates to L-glutamate-derived compounds of general formula (1) in which the R radical is a linear or branched C5 to C2 alkyl group, .—or the benzyl radical, .—or the phenethyl radical, for topical use as a medicament (or as a dermatological active ingredient) intended for the treatment and/or prevention of inflammatory dermatoses.
Type:
Application
Filed:
December 19, 2013
Publication date:
March 3, 2016
Applicant:
PIERRE FABRE DERMO-COSMETIQUE
Inventors:
Daniel REDOULES, Sylvie DAUNES-MARION, Stéphane POIGNY, Marie-Françoise ARIES
Abstract: The present invention relates to Formula (I), wherein—if X=NH, each of R1, R2, R3, R4 represents a hydrogen atom; if X=N, the core is aromatic, and R2, R3 and R4 represent hydrogen atoms, and R1=H, halogen, aryl, heteroaryl, alkenyl or acetylenyl; or R1, R2, R3, R4 are defined such that R1 or R2 or R3 or R4 represents a methyl group, and the three other radicals represent a hydrogen atom.
Type:
Grant
Filed:
December 10, 2012
Date of Patent:
November 10, 2015
Assignee:
PIERRE FABRE DERMO-COSMETIQUE
Inventors:
Daniel Redoules, Sylvie Daunes-Marion, Stephane Poigny, Marie-Florence Galliano