Abstract: The surgical instrument system disclosed is particularly useful for endoscopic procedures. In the preferred embodiment, a hemostatic clip applicator can be directly connected to a trigger assembly or indirectly connected to the trigger assembly through the use of an extension. The connection between the extension and the clip applicator is secured to prevent accidental release during the procedure. The applicator receives a longitudinal input and translates the input into relative component motion through the use of gearing to apply the clips. The handle stem assembly in an alternative embodiment has a drive rod configuration that connects to a closure member so as not only to provide the distal biasing force, but also to provide, if needed, a proximal pulling force to assist in release of the jaw if it becomes necessary.