Abstract: The present disclosure relates generally to conformation-specific antibodies that can bind to and neutralize the activity of phosphorylated-Threonine 231-tau protein (pT231-tau). The antibodies of the present technology are useful in methods for treating a neurological disorder associated with elevated cis-pT231-tau protein expression in a subject in need thereof.
Type:
Application
Filed:
January 17, 2023
Publication date:
September 14, 2023
Applicant:
Pinteon Therapeutics Inc.
Inventors:
Shankar Kumar, Naoya Tsurushita, Michael Ahlijanian, Martin Jefson
Abstract: The present disclosure relates generally to conformation-specific antibodies that can bind to and neutralize the activity of phosphorylated-Threonine 231-tau protein (pT231-tau). The antibodies of the present technology are useful in methods for treating a neurological disorder associated with elevated cis-pT231-tau protein expression in a subject in need thereof.
Type:
Grant
Filed:
November 8, 2018
Date of Patent:
February 28, 2023
Assignee:
Pinteon Therapeutics Inc.
Inventors:
Shankar Kumar, Naoya Tsurushita, Michael Ahlijanian, Martin Jefson
Abstract: The present disclosure relates generally to conformation-specific antibodies that can bind to and neutralize the activity of phosphorylated-Threonine 231-tau protein (pT231-tau). The antibodies of the present technology are useful in methods for treating a neurological disorder associated with elevated cis-pT231-tau protein expression in a subject in need thereof.
Type:
Application
Filed:
November 8, 2018
Publication date:
November 19, 2020
Applicant:
Pinteon Therapeutics Inc.
Inventors:
Shankar KUMAR, Naoya Tsurushita, Michael Ahlijanian, Martin JEFSON