Abstract: The present disclosure details novel modified anthracyclines, the synthesis thereof, and their use in treating patients with tumors. Preferred aspects of the disclosure involve modified anthracyclines which have an O-substituted aromatic ring on their sugar moiety. Other preferred aspects of the disclosure involve synthesis steps wherein a hydroxyl group on a sugar moiety to be added is blocked with a halo-substituted alkyl group during the process of adding it to an anthracycline ring compound.
Type:
Grant
Filed:
February 27, 1995
Date of Patent:
April 29, 1997
Assignees:
Waldemar Priebe, Piotr Skibicki, Roman Perez-Soler
Inventors:
Waldemar Priebe, Piotr Skibicki, Roman Perez-Soler