Abstract: Provided herein are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
Abstract: Provided herein are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
Type:
Grant
Filed:
June 10, 2019
Date of Patent:
November 29, 2022
Assignee:
Pipeline Therapeutics, Inc.
Inventors:
Yifeng Xiong, Thomas Schrader, Austin Chen, Jeffrey Roger Roppe, Jill Melissa Baccei, Yalda Bravo
Abstract: The present application describes the use of gamma secretase inhibitors and gamma secretase modulators for the treatment of cochlear synaptopathy.
Type:
Grant
Filed:
December 12, 2017
Date of Patent:
February 23, 2021
Assignee:
Pipeline Therapeutics, Inc.
Inventors:
Daniel Scott Lorrain, Michael Ming-Yuan Poon, Karin Joy Stebbins
Abstract: The present disclosure provides crystalline Compound I and crystalline Compound II, pharmaceutical compositions comprising one of said crystalline compounds suitable for intratympanic administration, and methods for treating otic disorders using the crystalline compounds and the pharmaceutical compositions.
Type:
Grant
Filed:
March 4, 2019
Date of Patent:
December 15, 2020
Assignee:
Pipeline Therapeutics, Inc.
Inventors:
Thomas Jon Seiders, Catherine Yuling Lee, Yiwei Li
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