Patents Assigned to Piramal Enterprises Limited
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Patent number: 11925618Abstract: The present invention relates to a pharmaceutical combination comprising a CDK inhibitor and at least one antioxidant enzyme inhibitor for use in the treatment of cancer. The present invention also relates to a method for the treatment of cancer comprising administering to a subject in need thereof, a therapeutically effective amount of a CDK inhibitor and a therapeutically effective amount of at least one antioxidant enzyme inhibitor. The pharmaceutical combination of the present invention exhibits synergistic effect when used in the treatment of cancer.Type: GrantFiled: December 13, 2021Date of Patent: March 12, 2024Assignee: Piramal Enterprises LimitedInventors: Owe Orwar, Sreesha Srinivasa, Prabha Mishra
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Patent number: 11839591Abstract: The present invention relates to a pharmaceutical combination comprising a cyclin dependent kinase (CDK) inhibitor represented by a compound of formula I (as described herein) or a pharmaceutically acceptable salt thereof; and at least one anticancer agent selected from a BRAF inhibitor or a MEK inhibitor, for use in the treatment of melanoma. The present invention also relates to a method for the treatment of melanoma comprising administering to a subject in need thereof, a therapeutically effective amount of a CDK inhibitor and a therapeutically effective amount of at least one anticancer agent selected from a BRAF inhibitor or a MEK inhibitor.Type: GrantFiled: February 5, 2021Date of Patent: December 12, 2023Assignee: Piramal Enterprises LimitedInventors: Veena Agarwal, Giridharan Periyasamy, Maggie Rathos, Ankita Srivastava, Sreesha Srinivasa
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Patent number: 11773077Abstract: The present invention relates to compound of Formula (I) containing carbon-carbon linker, a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, a prodrug, a polymorph, N-oxide, S-oxide, or a carboxylic acid isostere thereof; processes for their preparation; pharmaceutical compositions comprising said compounds; and their use for the treatment of the diseases or disorders mediated by GPR120 receptor.Type: GrantFiled: November 2, 2020Date of Patent: October 3, 2023Assignee: PIRAMAL ENTERPRISES LIMITEDInventors: Rajiv Sharma, Sanjay Kumar, Vishal Mahajan, Komal Bajaj, Pallavi Godse
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Publication number: 20220168273Abstract: The present invention relates to a pharmaceutical combination comprising a CDK inhibitor and at least one antioxidant enzyme inhibitor for use in the treatment of cancer. The present invention also relates to a method for the treatment of cancer comprising administering to a subject in need thereof, a therapeutically effective amount of a CDK inhibitor and a therapeutically effective amount of at least one antioxidant enzyme inhibitor. The pharmaceutical combination of the present invention exhibits synergistic effect when used in the treatment of cancer.Type: ApplicationFiled: December 13, 2021Publication date: June 2, 2022Applicant: Piramal Enterprises LimitedInventors: Owe Orwar, Sreesha Srinivasa, Prabha Mishra
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Patent number: 11260055Abstract: The present invention relates to an oral pharmaceutical composition, particularly a tablet, comprising an active ingredient lurasidone or its pharmaceutically acceptable salt(s) or solvate(s) thereof and one or more pharmaceutical excipient(s); and a process for its preparation.Type: GrantFiled: January 10, 2018Date of Patent: March 1, 2022Assignee: PIRAMAL ENTERPRISES LIMITEDInventors: Tejas Shah, Milan B. Agrawal, Narendra Patel, Devesh Bhatt, Umesh Barabde, Vipan Dhall
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Patent number: 11234963Abstract: The present invention relates to a pharmaceutical combination comprising a CDK inhibitor and at least one antioxidant enzyme inhibitor for use in the treatment of cancer. The present invention also relates to a method for the treatment of cancer comprising administering to a subject in need thereof, a therapeutically effective amount of a CDK inhibitor and a therapeutically effective amount of at least one antioxidant enzyme inhibitor. The pharmaceutical combination of the present invention exhibits synergistic effect when used in the treatment of cancer.Type: GrantFiled: December 23, 2019Date of Patent: February 1, 2022Assignee: Piramal Enterprises LimitedInventors: Owe Orwar, Sreesha Srinivasa, Prabha Mishra
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Publication number: 20220023263Abstract: The present invention relates to the pyrrolidine substituted with flavone derivatives, represented by the compounds of Formula (I) or a pharmaceutically acceptable salt, a solvate, a stereoisomer or a diastereoisomer thereof for use in the treatment of cancers associated with human papillomavirus. The present invention also relates to the pharmaceutical compositions containing the compounds of Formula (I) for the treatment of cancers associated with human papillomavirus.Type: ApplicationFiled: September 29, 2021Publication date: January 27, 2022Applicant: Piramal Enterprises LimitedInventors: Swati Ajay PIRAMAL, Muralidhara Padigaru, Veena R. Agarwal, Gandhali Ashwin Deshpande
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Publication number: 20210393589Abstract: The present invention relates to a pharmaceutical combination comprising a cyclin dependent kinase (CDK) inhibitor represented by a compound of formula I (as described herein) or a pharmaceutically acceptable salt thereof; and at least one anticancer agent selected from a BRAF inhibitor or a MEK inhibitor, for use in the treatment of melanoma. The present invention also relates to a method for the treatment of melanoma comprising administering to a subject in need thereof, a therapeutically effective amount of a CDK inhibitor and a therapeutically effective amount of at least one anticancer agent selected from a BRAF inhibitor or a MEK inhibitor.Type: ApplicationFiled: February 5, 2021Publication date: December 23, 2021Applicant: Piramal Enterprises LimitedInventors: Veena AGARWAL, Giridharan PERIYASAMY, Maggie RATHOS, Ankita SRIVASTAVA, Sreesha SRINIVASA
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Patent number: 11198703Abstract: The present invention relates to an industrially feasible and economically viable process for preparation of Bexagliflozin of formula V in significantly high yield and purity.Type: GrantFiled: May 9, 2018Date of Patent: December 14, 2021Assignee: PIRAMAL ENTERPRISES LIMITEDInventors: Milind Gharpure, Sanjay Kumar Sharma, Sandesh Vishwasrao, Prasad Vichare, Dipak Varal
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Patent number: 11160789Abstract: The present invention relates to the pyrrolidine substituted with flavone derivatives, represented by the compounds of Formula (I) or a pharmaceutically acceptable salt, a solvate, a stereoisomer or a diastereoisomer thereof for use in the treatment of cancers associated with human papillomavirus. The present invention also relates to the pharmaceutical compositions containing the compounds of Formula (I) for the treatment of cancers associated with human papillomavirus.Type: GrantFiled: April 9, 2020Date of Patent: November 2, 2021Assignee: PIRAMAL ENTERPRISES LIMITEDInventors: Swati Ajay Piramal, Muralidhara Padigaru, Veena R. Agarwal, Gandhali Ashwin Deshpande
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Patent number: 11084784Abstract: The present invention relates to a compound of formula I, or an isotopic form, stereoisomer, a tautomer, a pharmaceutically acceptable salt, a solvate, a polymorph, a prodrug, N-oxide or S-oxide thereof; and processes for their preparation. The invention further relates to pharmaceutical compositions containing the compounds and their use in the treatment of diseases or disorders mediated by ROR?.Type: GrantFiled: March 25, 2015Date of Patent: August 10, 2021Assignee: PIRAMAL ENTERPRISES LIMITEDInventors: Rajiv Sharma, Bichismita Sahu, Sunil Vasantrao Mali, Deepak Singh, Pramod Bhaskar Kumar, Mahesh Dawange, Hitesh Mistry
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Publication number: 20210147461Abstract: The present invention relates to an industrially feasible and economically viable process for preparation of SGLT2 inhibitors of formula X in significantly high yield and purity.Type: ApplicationFiled: May 9, 2018Publication date: May 20, 2021Applicant: PIRAMAL ENTERPRISES LIMITEDInventors: Milind GHARPURE, Sanjay Kumar SHARMA, Sandesh VISHWASRAO, Prasad VICHARE, Dipak VARAL
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Patent number: 11007174Abstract: The present invention relates to a pharmaceutical combination comprising a cyclin dependent kinase (CDK) inhibitor represented by a compound of formula I (as described herein) or a pharmaceutically acceptable salt thereof; and at least one anticancer agent selected from a BRAF inhibitor or a MEK inhibitor, for use in the treatment of melanoma. The present invention also relates to a method for the treatment of melanoma comprising administering to a subject in need thereof, a therapeutically effective amount of a CDK inhibitor and a therapeutically effective amount of at least one anticancer agent selected from a BRAF inhibitor or a MEK inhibitor.Type: GrantFiled: July 11, 2014Date of Patent: May 18, 2021Assignee: PIRAMAL ENTERPRISES LIMITEDInventors: Veena Agarwal, Giridharan Periyasamy, Maggie Rathos, Ankita Srivastava, Sreesha Srinivasa
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Publication number: 20210114977Abstract: The present invention relates to an improved asymmetric synthesis of alpha-branched amines (hereafter referred to as the compound) and relative chiral amines (1?) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual substrate specific regioselective ortho lithiation of substituted arene compounds, followed by its highly diastereoselective addition to N-tert-butanesulfinylimines resulting in the selective formation of alpha-branched sulfinyl amine and chiral amine; which on subsequently removing the sulfinyl group provides corresponding alpha-branched amines or relative chiral amines (1?).Type: ApplicationFiled: April 17, 2019Publication date: April 22, 2021Applicant: PIRAMAL ENTERPRISES LIMITEDInventors: Rajender Reddy LELETI, Sharadsrikar KOTTURI, Yogesh WAMAN, Chirag PATEL, Aditya PATWA, Rajesh SHENOY
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Synergistic pharmaceutical combination for the treatment of squamous cell carcinoma of head and neck
Patent number: 10980776Abstract: The present invention relates to a pharmaceutical combination for use in the treatment of squamous cell carcinoma, comprising a CDK inhibitor selected from the compounds of formula (I); or a pharmaceutically acceptable salt thereof and one or more antineoplastic agents selected from sorafenib, lapatinib, erlotinib, cisplatin, 5-fluorouracil, docetaxel or cetuximab or a pharmaceutically acceptable salt thereof. The said pharmaceutical combination exhibits synergy when used in the treatment of squamous cell carcinoma of head and neck (SCCHN). The invention also relates to a pharmaceutical composition comprising the said combination and a method for the treatment of squamous cell carcinoma of head and neck (SCCHN), using a therapeutically effective amount of said combination.Type: GrantFiled: February 8, 2019Date of Patent: April 20, 2021Assignee: PIRAMAL ENTERPRISES LIMITEDInventors: Veena Agarwal, Arun Balakrishnan, Giridharan Periyasamy -
Publication number: 20210087155Abstract: The present invention relates to a novel crystalline polymorphic form of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine hydrochloride; commonly known as vortioxetine hydrochloride (hereafter referred to as the compound (Ia) and process for its preparation comprising of treating the compound (Ia) (as described herein) with a ketone solvent or mixture of ketone solvent with other solvents. The present invention also relates to an improved process for the preparation of vortioxetine hydrobromide (Ia), comprising reacting the compound (I) (as described herein) with hydrogen bromide solution in acetic acid.Type: ApplicationFiled: February 5, 2019Publication date: March 25, 2021Applicant: PIRAMAL ENTERPRISES LIMITEDInventors: Milind GHARPURE, Sanjay Kumar SHARMA, Nainesh KANSAGARA, Yogesh ZALTE, Pravin THOMBRE, Sudha MENON
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Patent number: 10941133Abstract: The present invention relates to compound of Formula (I) containing carbon-carbon linker, a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, a prodrug, a polymorph, N-oxide, S-oxide, or a carboxylic acid isostere thereof; processes for their preparation; pharmaceutical compositions comprising said compounds; and their use for the treatment of the diseases or disorders mediated by GPR120 receptor.Type: GrantFiled: February 2, 2016Date of Patent: March 9, 2021Assignee: PIRAMAL ENTERPRISES LIMITEDInventors: Rajiv Sharma, Sanjay Kumar, Vishal Mahajan, Komal Bajaj, Pallavi Godse
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Publication number: 20210061752Abstract: The present invention relates to an improved asymmetric synthesis of alpha-(diarylmethyl) alkyl amines (hereafter referred to as the compound (1)) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual substrate specific regioselective lithiation of alpha-diarylmethanes, followed by its highly diastereoselective addition to N-tert-butanesulfinylimines resulting in the selective formation of chiral alpha-(diarylmethyl) alkyl amines 4 and chiral amine 5; which on subsequently removing the sulfinyl group provides corresponding alpha-(diarylmethyl) alkyl amines (1) or relative chiral amines (1?).Type: ApplicationFiled: March 20, 2019Publication date: March 4, 2021Applicant: PIRAMAL ENTERPRISES LIMITEDInventors: Rajender Reddy LELETI, Sharadsrikar KOTTURI, Yogesh WAMAN, Chirag PATEL, Rajesh SHENOY
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Publication number: 20200354308Abstract: The present invention provides an improved process for preparation of the L-threo-(2S,3R)-3-(3,4-dihydroxyphenyl)serine (I) or a salt thereof, which is known as Droxidopa; comprising (a) recovery of the by-product compound (V) (as described herein) from the crude compound (I), and (b) recycling and re-use it for the preparation of droxidopa. Accordingly, the present invention relates to an improved economical process for the preparation of L-threo-(2S,3R)-3-(3.4-dihydroxyphenyl)serine (I) or its pharmaceutically acceptable salts; wherein the process relates to recovery and recycling of the by-product compound (V) and also to re-use it for the preparation of droxidopa.Type: ApplicationFiled: January 3, 2019Publication date: November 12, 2020Applicant: PIRAMAL ENTERPRISES LIMITEDInventors: Milind GHARPURE, Ashutosh JAGTAP, Changdev RAUT, Navnath PATIL, Prashant LADKAT, Jaisankar KRISHNAPILLAI, Nirmal Kumar MANOHARAN, Kumaravel KANDASAMY
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Publication number: 20200299227Abstract: The present invention provides an improved process for preparation of L-threo-(2S,3R)-3-(3,4-dihydroxyphenyl)serine (I) (Droxidopa) and its salts; comprising (a) reaction of the aldehyde compound (III) (as described herein) with Metal complex (II) (as described herein), and (h) hydrolysis of the compound (IV) obtained from step (a) in presence of acid. The present invention also relates to a novel intermediates metal chiral complex (IV) for the preparation of Droxidopa.Type: ApplicationFiled: March 28, 2017Publication date: September 24, 2020Applicant: PIRAMAL ENTERPRISES LIMITEDInventors: Milind GHARPURE, Ashutosh JAGTAP, Changdev RAUT, Nainesh KANSAGARA, Jaisankar KRISHNAPILLAI, Nirmal Kumar MANOHARAN, Navnath PATIL