Abstract: This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).
Type:
Grant
Filed:
May 12, 2017
Date of Patent:
April 23, 2019
Assignee:
PIRAMAL IMAGING SA
Inventors:
Lutz Lehmann, Andrea Thiele, Tobias Heinrich, Thomas Brumby, Christer Halldin, Balazs Gulyas, Sangram Nag
Abstract: The present invention relates to novel compounds that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
Type:
Application
Filed:
July 15, 2016
Publication date:
September 20, 2018
Applicants:
AC IMMUNE S.A., PIRAMAL IMAGING SA
Inventors:
Heiko KROTH, Sreenivasachary NAMPALLY, Jérôme MOLETTE, Emanuele GABELLIERI, Hanno SCHIEFERSTEIN, Andre MÜLLER, Heribert SCHMITT-WILLICH, Mathias BERNDT
Abstract: This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).
Type:
Application
Filed:
May 12, 2017
Publication date:
January 25, 2018
Applicant:
PIRAMAL IMAGING SA
Inventors:
Lutz LEHMANN, Andrea THIELE, Tobias HEINRICH, Thomas BRUMBY, Christer HALLDIN, Balazs GULYAS, Sangram NAG
Abstract: The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein IIb/IIIa antagonists for imaging of thrombi.
Type:
Grant
Filed:
January 21, 2016
Date of Patent:
August 29, 2017
Assignee:
PIRAMAL IMAGING SA
Inventors:
Markus Berger, Martin Kruger, Jessica Lohrke, Michael Reinhardt, Holger Siebeneicher
Abstract: This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).
Type:
Grant
Filed:
July 21, 2014
Date of Patent:
June 20, 2017
Assignee:
PIRAMAL IMAGING SA
Inventors:
Lutz Lehmann, Andrea Thiele, Tobias Heinrich, Thomas Brumby, Christer Halldin, Balazs Gulyas, Sangram Nag
Abstract: The compounds and the synthesis of [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamate, their derivatives as set forth in formula (I) and their uses are described.
Type:
Grant
Filed:
January 13, 2014
Date of Patent:
June 28, 2016
Assignee:
PIRAMAL IMAGING SA
Inventors:
Ludger Dinkelborg, Matthias Friebe, Nikolaevna Raisa Krasikowa, Yuri Belokon, Fedorovna Olga Kuznetsova, Keith Graham, Lutz Lehmann, Mathias Berndt
Abstract: The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein 11b/IIIa antagonists for imaging of thrombi.
Type:
Grant
Filed:
August 17, 2012
Date of Patent:
May 24, 2016
Assignee:
PIRAMAL IMAGING SA
Inventors:
Markus Berger, Martin Kruger, Jessica Lohrke, Michael Reinhardt, Holger Siebeneicher
Abstract: The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein 11b/IIIa antagonists for imaging of thrombi.
Type:
Application
Filed:
January 21, 2016
Publication date:
May 19, 2016
Applicant:
PIRAMAL IMAGING SA
Inventors:
Markus BERGER, Martin KRUGER, Jessica LOHRKE, Michael REINHARDT, Holger SIEBENEICHER
Abstract: This invention relates to novel compounds suitable as precursors for the preparation of certain 18F labelled positron emission tomography (PET) tracers. Furthermore the invention relates to the preparation of such precursor molecules and to the preparation of PET tracers by 18F labelling of such precursors.
Type:
Grant
Filed:
October 17, 2011
Date of Patent:
April 19, 2016
Assignee:
PIRAMAL IMAGING SA
Inventors:
Andrea Thiele, Georg Kettschau, Tobias Heinrich, Lutz Lehmann, Christer Halldin, Sangram Nag, Andrea Varrone, Balazs Gulyas
Abstract: The invention is directed to formulations of lipophilic Amyloid beta ligand stilbene and more particularly to formulations which are capable to be administered parenterally e.g. intravenously, wherein the lipophilic Amyloid beta ligand stilbene is a fluorinated stilbene. Further, the invention is directed to a method for sterile filtration of formulations suitable for PET imaging of mammals pursuant to the invention.
Type:
Grant
Filed:
June 21, 2012
Date of Patent:
April 12, 2016
Assignee:
PIRAMAL IMAGING SA
Inventors:
Carsten Olbrich, Michael Krause, Andreas Burkhard, Annett Richter, Rainer Braun
Abstract: What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.
Type:
Grant
Filed:
February 5, 2014
Date of Patent:
April 12, 2016
Assignee:
PIRAMAL IMAGING SA
Inventors:
Matthias Friebe, Heribert Schmitt-Willich, Matthias Berndt, Ludger Dinkelborg, Norman Koglin, Keith Graham
Abstract: This invention relates to novel compounds suitable for labeling by 18F and to the corresponding 18F labeled compounds themselves, 19F-fluorinated analogs thereof and their use as reference standards, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by Positron Emission Tomography (PET).
Type:
Grant
Filed:
April 30, 2012
Date of Patent:
January 19, 2016
Assignee:
PIRAMAL IMAGING SA
Inventors:
Mathias Berndt, Andre Muller, Heribert Schmitt-Willich, Timo Stellfeld, Georg Kettschau, Thomas Brumby, Keith Graham, Lutz Lehmann, Jorma Haβfeld, Martin Kruger
Abstract: To provide a diagnostic and therapeutic medicament, a bombesin analog peptide antagonist conjugate is provided which has general Formula (I), wherein A is a metal chelator comprising at least one radionuclide metal, B is a spacer linked to N-terminal of C or a covalent bond and C is a bombesin analog peptide antagonist having a sequence as claimed, where further x is an integer from 1 to 3 and n is an integer from 1 to 6.
Type:
Grant
Filed:
February 27, 2009
Date of Patent:
May 19, 2015
Assignee:
Piramal Imaging, SA
Inventors:
Helmut Maecke, Jean Claude Reubi, Rosalba Mansi
Abstract: This invention relates to homoglutamic acid derivatives suitable for labeling or already labeled with 18F or 19F, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging.
Type:
Grant
Filed:
November 8, 2010
Date of Patent:
April 28, 2015
Assignee:
Piramal Imaging SA
Inventors:
Heribert Schmitt-Willich, Niels Böhnke, Norman Koglin, Andre Müller, Mathias Berndt, Matthias Friebe, Lutz Lehmann
Abstract: This invention relates to novel precursors suitable for 18F radiolabeling of glutamate derivatives, methods for preparing such compounds and its intermediates, compositions comprising such compounds, kits comprising such compounds or compositions and methods for 18F radiolabeling of glutamate derivatives wherein the obtained 18F radiolabeled glutamate derivatives are suitable for diagnostic imaging by Positron Emission Tomography (PET) of proliferative diseases e.g. tumor in mammals.
Type:
Grant
Filed:
April 30, 2012
Date of Patent:
April 7, 2015
Assignee:
Piramal Imaging SA
Inventors:
Christina Hultsch, Michael Harre, Filip Novak, Mathias Berndt, Matthias Friebe, Heribert Schmitt-Willich, Dae Yoon Chi, Byoung Se Lee, Sang Don Park
Abstract: The invention relates to a process for the production of radiotracers. In particular, this invention relates the isolation of radiotracers with containers filled with a stationary phase.
Type:
Grant
Filed:
July 6, 2010
Date of Patent:
March 3, 2015
Assignee:
Piramal Imaging SA
Inventors:
Holger Siebeneicher, Keith Graham, Mathias Berndt
Abstract: This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).
Type:
Application
Filed:
July 21, 2014
Publication date:
January 29, 2015
Applicant:
PIRAMAL IMAGING SA
Inventors:
Lutz LEHMANN, Andrea THIELE, Tobias HEINRICH, Thomas BRUMBY, Christer HALLDIN, Balazs GULYAS, Sangram NAG