Patents Assigned to Piramal Life Sciences Limited
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Patent number: 7932294Abstract: The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.Type: GrantFiled: August 26, 2005Date of Patent: April 26, 2011Assignees: Apparao Satyam, Piramal Life Sciences LimitedInventor: Apparao Satyam
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Patent number: 7914824Abstract: The present invention relates to the use of standardized extract of Tinospora cordifolia as an immunoadjuvant in the treatment of renal disorders such as nephrotic syndrome and chronic recurrent urinary tract infections, both complicated and uncomplicated. The present invention also relates to pharmaceutical compositions comprising the standardized extract of Tinospora cordifolia. The present invention further relates to a method of treatment of renal disorders such as recurrent urinary tract infection particularly occurring due to relapsing E. coli, Klebsiella and other gram negative infections and to a method of treatment of nephrotic syndrome using standardized extract of Tinospora cordifolia as an immunoadjuvant in conjunction with conventional therapy.Type: GrantFiled: April 4, 2005Date of Patent: March 29, 2011Assignee: Piramal Life Sciences LimitedInventors: Vidya Narayan Acharya, Triptikumar Mukhopadhyay, Swati Ajay Piramal
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Patent number: 7915301Abstract: The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R1, R2, R3, R4, R5, R6, R7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of the compounds of formula (Ia), to methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, to the use of the compounds of formula (Ia) in the treatment and prophylaxis of diseases, which can be treated or prevented by the inhibition of cyclin-dependent kinases such as cancer, to the use of the compounds of formula (Ia) in the preparation of medicaments to be applied in such diseases.Type: GrantFiled: July 18, 2007Date of Patent: March 29, 2011Assignee: Piramal Life Science LimitedInventors: Bansi Lal, Kalpana Joshi, Sanjeev Kulkarni, Malcolm Mascarenhas, Shrikant Kamble, Maggie Joyce Rathos, Rajendrakumar Joshi
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Patent number: 7862837Abstract: The present invention relates to a novel herbal composition comprising extract of leaves of Polyalthia longifolia and method of manufacture of said composition. The present invention relates to a herbal extract selectively comprising a compound 16-hydroxycleroda-3,13(14)-dien-15,16-olide (compound 1), as a bioactive marker and optionally other active(s). The invention also discloses methods of administration of the said herbal composition for the treatment of various inflammatory disorders. Optionally the said extract may be combined with other bioactive substances to obtain a synergistic effect.Type: GrantFiled: January 5, 2007Date of Patent: January 4, 2011Assignee: Piramal Life Sciences LimitedInventors: Vijay Chauhan, Muthusamy Veluchamy Shanmuganathan
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Publication number: 20100324026Abstract: Compounds of formula 1: are disclosed, wherein V is CH2; W is S(O)m; m is the integer 0, 1 or 2; U is O, C(O), CR13R14 or NR15; where R13 is H, alkyl; R14 is H, OH, OR13 or OCOR13; R15 is H, alkyl, cycloalkyl, alkenyl, C(O)R13, C(O)OR13 or alkylaminocarbonyl; R1, R2, R3, R4, R5, R6, R7 and R5 are as defined herein. These compounds are inhibitors of tumor necrosis factor-alpha (TNF-?) and are useful as medicaments for the treatment and prevention of disorders caused by increased TNF-? activity, in particular inflammations.Type: ApplicationFiled: August 11, 2010Publication date: December 23, 2010Applicant: Piramal Life Sciences LimitedInventors: Bansi LAL, Somesh Sharma, Usha Ghosh, Swati Bal-Tembe, Tulsidas More, Pravin Gagare, Sunil Jadhav, Shashikant Patil, Asha Kulkarni-Almeida, Sapna Parikh, Radha Panicker, Anagha Damre, Ravindra Gupte
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Publication number: 20100305094Abstract: Compounds of formula 1: are disclosed, wherein V is CH2; W is S(O)m; m is the integer 0, 1 or 2; U is O, C(O), CR13R14 or NR15; where R13 is H, alkyl; R14 is H, OH, OR13 or OCOR13; R15 is H, alkyl, cycloalkyl, alkenyl, C(O)R13, C(O)OR13 or alkylaminocarbonyl; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. These compounds are inhibitors of tumor necrosis factor-alpha (TNF-?) and are useful as medicaments for the treatment and prevention of disorders caused by increased TNF-? activity, in particular inflammations.Type: ApplicationFiled: August 11, 2010Publication date: December 2, 2010Applicant: Piramal Life Sciences LimitedInventors: Bansi Lal, Somesh Sharma, Usha Ghosh, Swati Bal-Tembe, Tulsidas More, Asha Kulkarni-Almeida, Sapna Parikh, Radha Panicker, Anagha Damre, Ravindra Gupte
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Publication number: 20100305057Abstract: A novel pharmaceutical combination comprising a cytotoxic antineoplastic agent selected from a the group consisting of paclitaxel, docetaxel, doxorubicin and gemcitabine or a pharmaceutically acceptable salt thereof and at least one cyclin dependent kinase (CDK) inhibitor; wherein the said combination exhibits synergistic effects when used in the treatment of cancer. The invention also relates to a method for the treatment of cancer, using a therapeutically effective amount of the said combination.Type: ApplicationFiled: May 15, 2007Publication date: December 2, 2010Applicant: PIRAMAL LIFE SCIENCES LIMITEDInventors: Maggie Rathos, Kalpana Joshi, Harshal Khanwalkar, Somesh Sharma
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Patent number: 7834001Abstract: Guanidine derivatives having a condensed tricyclic ring of formula 1: are disclosed, wherein U is C(O), CRaRb, O, NRa or S(O)m; V is CRaRb or NRa; W is S(O)m; wherein Ra is H, alkyl, cycloalkyl, alkenyl or aralkyl; Rb is H, alkyl, OH, ORa or OCORa, and m is the integer 0, 1 or 2; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein with the proviso that at least one of R1, R2, R3, R4, R5, R6, R7 or R8 is guanidino or guanidino carbonyl. These derivatives are sodium-proton exchange inhibitors and are useful as medicaments for the treatment of, for example, organ disorders associated with ischemia and reperfusion, cardiac arrhythmia, cardiac hypertrophy, hypertension, cell proliferative disorders and diabetes.Type: GrantFiled: November 8, 2005Date of Patent: November 16, 2010Assignee: Piramal Life Sciences LimitedInventors: Bansi Lal, Swati Bal-Tembe, Usha Ghosh, Arun Kumar Jain, Tulsidas More
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Patent number: 7834052Abstract: Compounds of formula 1: are disclosed, wherein V is CH2; W is S(O)m; m is the integer 0, 1 or 2; U is O, C(O), CR13R14 or NR15; where R13 is H, alkyl; R14 is H, OH, OR13 or OCOR13; R15 is H, alkyl, cycloalkyl, alkenyl, C(O)R13, C(O)OR13 or alkylaminocarbonyl; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. These compounds are inhibitors of tumor necrosis factor-alpha (TNF-?) and are useful as medicaments for the treatment and prevention of disorders caused by increased TNF-? activity, in particular inflammations.Type: GrantFiled: November 8, 2005Date of Patent: November 16, 2010Assignee: Piramal Life Sciences LimitedInventors: Bansi Lal, Usha Ghosh, Swati Bal-Tembe, Tulsidas More, Pravin Gagare, Sunil Jadhav, Shashikant Patil
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Publication number: 20100267690Abstract: Guanidine derivatives having a condensed tricyclic ring of formula 1: are disclosed, wherein U is C(O), CRaRb, O, NRa or S(O)m; V is CRaRb or NRa; W is S(O)m; wherein Ra is H, alkyl, cycloalkyl, alkenyl or aralkyl; Rb is H, alkyl, OH, ORa or OCORa, and m is the integer 0, 1 or 2; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein with the proviso that at least one of R1, R2, R3, R4, R5, R6, R7 or R8 is guanidino or guanidino carbonyl. These derivatives are sodium-proton exchange inhibitors and are useful as medicaments for the treatment of, for example, organ disorders associated with ischemia and reperfusion, cardiac arrhythmia, cardiac hypertrophy, hypertension, cell proliferative disorders and diabetes.Type: ApplicationFiled: June 30, 2010Publication date: October 21, 2010Applicant: Piramal Life Sciences LimitedInventors: Bansi LAL, Swati Bal-Tembe, Usha Ghosh, Arun Kumar Jain, Tulsidas More, Anil Ghate, Jacqueline Trivedi, Sapna Parikh
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Publication number: 20100256161Abstract: This invention relates to novel fused bicyclic compounds of the general formula (I): wherein the symbols are defined herein, to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and to methods of using the compounds, alone or in combination with other therapeutic agents. The compounds are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, and are therefore useful for the inhibition of platelet aggregation, and for the treatment of thrombotic diseases and other diseases.Type: ApplicationFiled: June 8, 2010Publication date: October 7, 2010Applicant: Piramal Life Sciences LimitedInventors: Bansi Lal, Ashok Kumar Gangopadhyay, Vadlamudi V.S.V Rao, Ravindra Dattatraya Gupte, Radha Bhaskar Panicker, Eleanor Pinto De Souza, Gopal Vishnu Gole, Asha Kulkarni-Almeida, Sridevi Krishnan
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Patent number: 7759387Abstract: This invention relates to novel fused bicyclic compounds of the general formula (I): wherein the symbols are defined herein, to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and to methods of using the compounds, alone or in combination with other therapeutic agents. The compounds are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, and are therefore useful for the inhibition of platelet aggregation, and for the treatment of thrombotic diseases and other diseases.Type: GrantFiled: September 30, 2004Date of Patent: July 20, 2010Assignee: Piramal Life Sciences LimitedInventors: Bansi Lal, Ashok Kumar Gangopadhyay, Vadlamudi V. S. V. Rao, Ravindra Dattatraya Gupte, Gopal Vishnu Gole, Asha Kulkarni-Almeida, Sridevi Krishnan, Radha Bhaskar Panicker, Eleanor Pinto De Souza
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Publication number: 20100168008Abstract: The present invention relates to nucleotide and protein sequences of epiregulin and epiregulin like proteins and nucleotides and methods employing them as a drug response marker in inflammatory conditions. The invention also provides epiregulin protein for treatment of inflammatory conditions like psoriasis and rheumatoid arthritis alone or in combination with one or more anti-inflammatory compounds.Type: ApplicationFiled: November 19, 2007Publication date: July 1, 2010Applicant: PIRAMAL LIFE SCIENCES LIMITED.Inventors: Muralidhara Padigaru, Somesh Sharma, Arvind Thakkar, Anandharajan Rathina Sabapathy, Sapna Hasit Parikh, Usha Ghosh
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Publication number: 20100034746Abstract: The present invention relates to a method for evaluating a test compound for antithrombotic activity, thrombolytic activity, or a combination thereof. This method can include providing or employing a donor test animal and a recipient test animal. The donor and recipient test animals can have been pretreated with test compound. The donor test animal can be configured to provide oxygenated blood to the recipient test animal through a thrombus inducing system. This method also includes initiating transport of blood from the donor test animal to the recipient test animal through the thrombus inducing system. The method can include interrupting respiration of the recipient test animal and determining the length of time that the recipient test animal survives. In this method, a survival time longer than a predetermined threshold time indicates that the test compound has antithrombotic activity, thrombolytic activity, or a combination thereof.Type: ApplicationFiled: March 18, 2008Publication date: February 11, 2010Applicant: Piramal Life Sciences LimitedInventors: Ravindra Dattatraya Gupte, Aditi Amol Tannu, Radha Bhaskar Panicker, Somesh Sharma
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Publication number: 20100028472Abstract: A herbal composition comprising a therapeutically effective amount of the extract of Piper betle leaves as an active ingredient either alone, or with a pharmaceutically acceptable excipient. A process for the preparation of the herbal composition is provided. The herbal composition is adapted for the treatment of chronic myeloid leukemia (CML; chronic myelogenous leukemia) showing resistance to treatment with imatinib (GleevecĀ® or GlivecĀ®).Type: ApplicationFiled: February 20, 2007Publication date: February 4, 2010Applicant: PIRAMAL LIFE SCIENCES LIMITEDInventors: Kalpana Sanjay Joshi, Vilas Wagh, Somesh Sharma
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Publication number: 20100010002Abstract: The present invention relates to the use of caffeic acid or a derivative thereof represented by the following general formula (1) wherein X is O, NH, or heterocyclyl; R may be present or absent and if present, is H, alkyl, aryl, or heterocyclyl; in all its stereoisomeric and tautomeric forms, and mixtures thereof in all ratios, and a pharmaceutically acceptable salt, pharmaceutically acceptable solvate, pharmaceutically acceptable polymorph or a prodrug, in the treatment of chronic myeloid leukemia (CML) which is resistant to treatment with GLEEVEC. The invention also relates to a method for reducing the proliferation of cells that are resistant to GLEEVEC by contacting the cells with a compound of general formula (1).Type: ApplicationFiled: August 20, 2007Publication date: January 14, 2010Applicant: Piramal Life Sciences LimitedInventors: Kalpana Sanjay Joshi, Meenakshi Sivakumar, Valmik Sopan Aware, Vilas Sampatrao Wagh, Amit Deshpande, Ankush Gangaram Sarde, Somesh Sharma
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Patent number: 7635494Abstract: This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7-Hydroxy-4,11(13)-eudesmadien-12,6-olide) (compound 1), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (compound 1) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor- (TNF-?) and interleukin (IL-1, IL-6, IL-8) inhibitory activity of the said compositions.Type: GrantFiled: March 28, 2008Date of Patent: December 22, 2009Assignee: Piramal Life Sciences LimitedInventors: Vijay Chauhan, Ashish Suthar, Dhananjay Sapre, Swati Bal-Tembe, Ashok Kumar Gangopadhyay, Asha Kulkarni-Almeida, Sapna Hasit Parikh, Ravindra Dattatraya Gupte, Nilesh Madhukar Dagia, Somesh Sharma, Shruta Sudheer Dadarkar, Mahesh Gundaji Jadhav, Aditi Amol Tannu
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Patent number: 7635493Abstract: Compositions containing extract of hedychium spicatum are useful for treating Tinea infections by topical application. Extracts from rhizomes of hedychium spicatum are particularly useful.Type: GrantFiled: June 17, 2005Date of Patent: December 22, 2009Assignee: Piramal Life Sciences LimitedInventors: Vijay Singh Chauhan, Kalkunte S. Satyan, Kavita P. Kadam
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Publication number: 20090297644Abstract: The present invention relates to bioadhesive compositions for oral application, which comprise a curcuminoid substance as an active ingredient. The present invention also relates to method of using said bioadhesive composition for the prevention and treatment of periodontal diseases such as gingivitis and other periodontal diseases.Type: ApplicationFiled: June 29, 2007Publication date: December 3, 2009Applicant: PIRAMAL LIFE SCIENCES LIMITEDInventors: Swati Ajay Piramal, Shripad Rhushikesh Jathar, Rajesh Prabhamal Sirwani, Prakash Malhotra
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Publication number: 20090291155Abstract: The present invention relates to a novel herbal composition comprising extract of leaves of Polyalthia longifolia and method of manufacture of said composition. The present invention relates to a herbal extract selectively comprising a compound 16-hydroxycleroda-3,13(14)-dien-15,16-olide (compound 1), as a bioactive marker and optionally other active(s). The invention also discloses methods of administration of the said herbal composition for the treatment of various inflammatory disorders. Optionally the said extract may be combined with other bioactive substances to obtain a synergistic effect.Type: ApplicationFiled: January 5, 2007Publication date: November 26, 2009Applicant: Piramal Life Sciences LimitedInventors: Vijay Chauhan, Muthusamy Veluchamy Shanmuganathan