Patents Assigned to PIRAMAL PHARMA LIMITED
  • Publication number: 20230272448
    Abstract: The present invention relates to obtaining single incubation condition for cocktail of probe substrates of 8 major Cytochrome P450 (CYP) isoforms to assess in vitro drug-drug interactions (DDIs) of novel drug candidates using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) method. The present invention provides an improved and reduced substrate concentration and is developed in lower microsomal protein to avoid any non-specific binding of substrates with the microsomal proteins.
    Type: Application
    Filed: July 30, 2021
    Publication date: August 31, 2023
    Applicant: PIRAMAL PHARMA LIMITED
    Inventors: Vinod SANNA, Sharadsrikar KOTTURI, Mahendra SHUKLA, Mohammed Salauddin SHAIKH, Himani SAMAR
  • Publication number: 20230263777
    Abstract: The present invention relates to a stable, solid composition of Azilsartan or its pharmaceutically acceptable salts thereof and one or more pharmaceutically acceptable excipient(s); optionally, the said composition further comprises a diuretic, preferably a thiazide diuretic such as Chlorthalidone, and processes for its preparation.
    Type: Application
    Filed: July 2, 2021
    Publication date: August 24, 2023
    Applicant: PIRAMAL PHARMA LIMITED
    Inventors: Umesh BARABDE, Vishakh KHARAT, Amit JAIN, Dhananjay SINGARE, Mahek NAIK, Nawanit SHARMA
  • Publication number: 20220372011
    Abstract: The present invention relates to an improved process for 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one (I). The process involves reaction of compound of formula (II) with sodium acetate in presence of catalytic amount of potassium iodide in dimethyl formamide solvent at 25-30° C. to give 5-methyl-2-oxo-1,3-dioxol-4-yl)methyl acetate (IV) which was further Acid hydrolysed by IPA.HCl in Isopropyl alcohol solvent to yield 4-(hydroxymethyl)-5-methyl-1,3-dioxol-2-one (I).
    Type: Application
    Filed: October 8, 2020
    Publication date: November 24, 2022
    Applicant: PIRAMAL PHARMA LIMITED
    Inventors: Changdev RAUT, Ajay KUMBHAR, Tanaji JADHAV, Ganesh WAGH, Ashutosh JAGTAP, Sivakumar RALLAPALLI
  • Patent number: 11447443
    Abstract: The present invention provides an improved process for preparation of L-threo-(2S,3R)-3-(3,4-dihydroxyphenyl)serine (I) (Droxidopa) and its salts; comprising (a) reaction of the aldehyde compound (III) (as described herein) with Metal complex (II) (as described herein), and (h) hydrolysis of the compound (IV) obtained from step (a) in presence of acid. The present invention also relates to a novel intermediates metal chiral complex (IV) for the preparation of Droxidopa.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: September 20, 2022
    Assignee: PIRAMAL PHARMA LIMITED
    Inventors: Milind Gharpure, Ashutosh Jagtap, Changdev Raut, Nainesh Kansagara, Jaisankar Krishnapillai, Nirmal Kumar Manoharan, Navnath Patil
  • Patent number: 11401273
    Abstract: The present invention relates to an improved asymmetric synthesis of azaspiro or diazaspiro compound (hereafter referred to as the compound 5, (5A) or (5N)) or their pharmaceutically acceptable salts and derivatives; through the formation of intermediate compounds 4, (4A) or (4N) respectively. The process comprises an unusual substrate specific highly diastereoselective as well as enantio-enriched 1-substituted 2-azaspiro[3.3]heptane or 1-substituted 2-diazaspiro[3.3]heptane compounds with high diastereoselectivity by addition of a cyclobutane carboxylate anion to a Davis-Ellman's imine, followed by reduction and cyclisation resulting in the selective formation of azaspiro or diazaspiro intermediate compound 4, (4A) or (4N); which on subsequently removing the sulfinyl group provides corresponding azaspiro or diazaspiro compound 5, (5A) or (5N) respectively.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: August 2, 2022
    Assignee: PIRAMAL PHARMA LIMITED
    Inventors: Rajender Reddy Leleti, Yogesh Waman, Priya Kallure, Zubeda Begum, Thumban Divya, Kumara Swamy Nalivela, Saurabh Vijay, Paranjay Parikh, Sharadsrikar Kotturi, Chirag Patel, Krishna Nayak, Kasimraza Baharooni, Vinkal Zalavadiya
  • Publication number: 20220185788
    Abstract: The present invention relates to an improved process for the preparation of N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)octanamide (A), which is known as ELIGLUSTAT and its pharmaceutically acceptable salts, comprising the formation of novel intermediate metal complex (III), which on hydrolysis in presence of acid provides amine compound (IV) (as described herein), which is treated with pyrrolidine and subsequently reduced to convert into Eliglustat (A).
    Type: Application
    Filed: March 19, 2020
    Publication date: June 16, 2022
    Applicant: PIRAMAL PHARMA LIMITED
    Inventors: Venkataramana Rao RAO, Sharadsrikar KOTTURI, Abdul BASITH, Ramesh Babu BANDI, Manoj Kumar MANDADI
  • Patent number: 11312740
    Abstract: The present invention relates to an industrially feasible and economically viable process for preparation of SGLT2 inhibitors of formula X in significantly high yield and purity.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: April 26, 2022
    Assignee: PIRAMAL PHARMA LIMITED
    Inventors: Milind Gharpure, Sanjay Kumar Sharma, Sandesh Vishwasrao, Prasad Vichare, Dipak Varal
  • Patent number: 11299455
    Abstract: The present invention relates to an improved process for diastereoselective synthesis of vicinal diamines (1). The process involves highly regio- and diastereoselective addition of 2-azaallyl anions (4) to N-tert-butanesulfinylimines (5) to produce vicinal diamines (1).
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: April 12, 2022
    Assignee: PIRAMAL PHARMA LIMITED
    Inventors: Rajender Reddy Leleti, Sharadsrikar Kotturi, Kumara Swamy Nalivela, Chirag Patel, Poojabahen Raval, Vinkal Zalavadiya
  • Patent number: 11279668
    Abstract: The present invention relates to an improved asymmetric synthesis of alpha-(diarylmethyl) alkyl amines (hereafter referred to as the compound (1)) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual substrate specific regioselective lithiation of alpha-diarylmethanes. followed by its highly diastereoselective addition to N-tert-butanesulfinylimines resulting in the selective formation of chiral alpha-(diarylmethyl) alkyl amines 4 and chiral amine 5; which on subsequently removing the sulfinyl group provides corresponding alpha-(diarylmethyl) alkyl amines (1) or relative chiral amines (1?).
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: March 22, 2022
    Assignee: PIRAMAL PHARMA LIMITED
    Inventors: Rajender Reddy Leleti, Sharadsrikar Kotturi, Yogesh Waman, Chirag Patel, Rajesh Shenoy
  • Patent number: 11279672
    Abstract: The present invention relates to an improved asymmetric synthesis of alpha-branched amines (hereafter referred to as the compound) and relative chiral amines (1?) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual substrate specific regioselective ortho lithiation of substituted arene compounds, followed by its highly diastereoselective addition to N-tert-butanesulfinylimines resulting in the selective formation of alpha-branched sulfinyl amine and chiral amine; which on subsequently removing the sulfinyl group provides corresponding alpha-branched amines or relative chiral amines (1?).
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: March 22, 2022
    Assignee: PIRAMAL PHARMA LIMITED
    Inventors: Rajender Reddy Leleti, Sharadsrikar Kotturi, Yogesh Waman, Chirag Patel, Aditya Patwa, Rajesh Shenoy
  • Publication number: 20220073454
    Abstract: The present invention relates to an improved process for diastereoselective synthesis of vicinal diamines (1). The process involves highly regio- and diastereoselective addition of 2-azaallyl anions (4) to N-tert-butanesulfinylimines (5) to produce vicinal diamines (1).
    Type: Application
    Filed: July 11, 2019
    Publication date: March 10, 2022
    Applicant: PIRAMAL PHARMA LIMITED
    Inventors: Rajender Reddy LELETI, Sharadsrikar KOTTURI, Kumara Swamy NALIVELA, Chirag PATEL, Poojabahen RAVAL, Vinkal ZALAVADIYA
  • Publication number: 20220041609
    Abstract: The present invention relates to an improved asymmetric synthesis of azaspiro or diazaspiro compound (hereafter referred to as the compound 5, (5A) or (5N)) or their pharmaceutically acceptable salts and derivatives; through the formation of intermediate compounds 4, (4A) or (4N) respectively. The process comprises an unusual substrate specific highly diastereoselective as well as enantio-enriched 1-substituted 2-azaspiro[3.3]heptane or 1-substituted 2-diazaspiro[3.3]heptane compounds with high diastereoselectivity by addition of a cyclobutane carboxylate anion to a Davis-Ellman's imine, followed by reduction and cyclisation resulting in the selective formation of azaspiro or diazaspiro intermediate compound 4, (4A) or (4N); which on subsequently removing the sulfinyl group provides corresponding azaspiro or diazaspiro compound 5, (5A) or (5N) respectively.
    Type: Application
    Filed: November 19, 2019
    Publication date: February 10, 2022
    Applicant: PIRAMAL PHARMA LIMITED
    Inventors: Rajender Reddy LELETI, Yogesh WAMAN, Priya KALLURE, Zubeda BEGUM, Thumban DIVYA, Kumara Swamy NALIVELA, Saurabh VIJAY, Paranjay PARIKH, Sharadsrikar KOTTURI, Chirag PATEL, Krishna NAYAK, Kasimraza BAHAROONI, Vinkal ZALAVADIYA
  • Publication number: 20220000787
    Abstract: The present invention relates to a delayed-release pharmaceutical composition comprising an active ingredient prednisone and one or more pharmaceutical excipient(s). The invention further relates to a process for preparation of said pharmaceutical composition for oral administration, particularly a tablet, comprising prednisone with one or more pharmaceutically acceptable excipient(s), wherein the tablet is formulated using a coating technique which has a significant impact on drug release.
    Type: Application
    Filed: June 30, 2021
    Publication date: January 6, 2022
    Applicant: PIRAMAL PHARMA LIMITED
    Inventors: Umesh V. BARABDE, Narendra PATEL, Dinesh M. MORKHADE, Bhushan Santoshrao BHOYAR
  • Patent number: 11192848
    Abstract: The present invention provides an improved process for preparation of the L-threo-(2S,3R)-3-(3 4-dihydroxyphenyl)serine (I) or a salt thereof, which is known as Droxidopa; comprising (a) recovery of the by-product compound (V) (as described herein) from the crude compound (I), and (b) recycling and re-use it for the preparation of droxidopa. Accordingly, the present invention relates to an improved economical process for the preparation of L-threo-(2S,3R)-3-(3.4-dihydroxyphenyl)serine (I) or its pharmaceutically acceptable salts; wherein the process relates to recovery and recycling of the by-product compound (V) and also to re-use it for the preparation of droxidopa.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: December 7, 2021
    Assignee: PIRAMAL PHARMA LIMITED
    Inventors: Milind Gharpure, Ashutosh Jagtap, Changdev Raut, Navnath Patil, Prashant Ladkat, Jaisankar Krishnapillai, Nirmal Kumar Manoharan, Kumaravel Kandasamy
  • Publication number: 20210371992
    Abstract: The present invention provides to a simple and efficient electrochemical organic reaction setup, particularly to carry out electrolysis reactions in chemistry laboratory and methods for performing the same with good yield and less impurity formation using the instantly presented device. Accordingly, the present invention relates to an electrochemical organic reaction setup as shown in fig. A-J comprising (a) Current source (6), (b) Reaction vessel or vial assembly set up comprising reaction vessel or vial (3), anode (1) cathode (2), Guard tube (8), alligator clip (5) and (c) Reaction mixture (4); for use in electrochemical reactions involving coupling between carbocyclic or heterocyclic rings and also in ring formation reactions between two or more moieties.
    Type: Application
    Filed: November 20, 2019
    Publication date: December 2, 2021
    Applicant: PIRAMAL PHARMA LIMITED
    Inventors: Tanay GHOSAL, Vishal NAGAR, Sharadsrikar KOTTURI, Sasikumar KUTTAAPPAN
  • Publication number: 20210229063
    Abstract: The present invention provides an improved photochemical rector assembly device, particularly a light emitting diode (LED) based small photochemical reactor and methods for performing the photochemical transformations using the instantly presented device. Accordingly, the present invention relates to an improved photochemical transformation reaction by exposing the reaction mixture to a photochemical rector device as shown in fig. A-G, comprising of (i) light emitting diode (LED) panel (1), (ii) Aluminium based heat sink, and (iii) cooling fan.
    Type: Application
    Filed: August 19, 2019
    Publication date: July 29, 2021
    Applicant: PIRAMAL PHARMA LIMITED
    Inventors: Tushar PATEL, Sharadsrikar KOTTURI, Sasikumar KUTTAPPAN
  • Publication number: 20210171442
    Abstract: The present invention provides an improved process for the preparation of 3-(4-chlorophenyl)-3-cyanopropanoic acid (compound (A)) and further its transformation to Baclofen (I). The process comprises reaction of compound (II) with Glyoxylic acid to obtain 3-(4-chlorophenyl)-3-cyanoacrylic acid (III); followed by the ‘in-situ’ reduction of (III) in the presence of a reducing agent to provide the compound (A). Alternatively, the compound (A) is obtained by the process comprising reacting 2-(4-chlorophenyl)acetonitrile (II) with haloacetic acid (IV) in the presence of a base. The compound 3-(4-chlorophenyl)-3-cyanopropanoic acid (A) undergoes hydrogenation in the presence of a metal catalyst and ammonia solution to provide Baclofen (I).
    Type: Application
    Filed: January 20, 2021
    Publication date: June 10, 2021
    Applicant: PIRAMAL PHARMA LIMITED
    Inventors: Ashutosh JAGTAP, Milind GHARPURE, Navnath SHINDE, Navnath PATIL, Changdev RAUT, Dhileepkumar KRISHNAMURTHY