Patents Assigned to PIRAMAL PHARMA LIMITED
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Publication number: 20230272448Abstract: The present invention relates to obtaining single incubation condition for cocktail of probe substrates of 8 major Cytochrome P450 (CYP) isoforms to assess in vitro drug-drug interactions (DDIs) of novel drug candidates using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) method. The present invention provides an improved and reduced substrate concentration and is developed in lower microsomal protein to avoid any non-specific binding of substrates with the microsomal proteins.Type: ApplicationFiled: July 30, 2021Publication date: August 31, 2023Applicant: PIRAMAL PHARMA LIMITEDInventors: Vinod SANNA, Sharadsrikar KOTTURI, Mahendra SHUKLA, Mohammed Salauddin SHAIKH, Himani SAMAR
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Publication number: 20230263777Abstract: The present invention relates to a stable, solid composition of Azilsartan or its pharmaceutically acceptable salts thereof and one or more pharmaceutically acceptable excipient(s); optionally, the said composition further comprises a diuretic, preferably a thiazide diuretic such as Chlorthalidone, and processes for its preparation.Type: ApplicationFiled: July 2, 2021Publication date: August 24, 2023Applicant: PIRAMAL PHARMA LIMITEDInventors: Umesh BARABDE, Vishakh KHARAT, Amit JAIN, Dhananjay SINGARE, Mahek NAIK, Nawanit SHARMA
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Publication number: 20220372011Abstract: The present invention relates to an improved process for 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one (I). The process involves reaction of compound of formula (II) with sodium acetate in presence of catalytic amount of potassium iodide in dimethyl formamide solvent at 25-30° C. to give 5-methyl-2-oxo-1,3-dioxol-4-yl)methyl acetate (IV) which was further Acid hydrolysed by IPA.HCl in Isopropyl alcohol solvent to yield 4-(hydroxymethyl)-5-methyl-1,3-dioxol-2-one (I).Type: ApplicationFiled: October 8, 2020Publication date: November 24, 2022Applicant: PIRAMAL PHARMA LIMITEDInventors: Changdev RAUT, Ajay KUMBHAR, Tanaji JADHAV, Ganesh WAGH, Ashutosh JAGTAP, Sivakumar RALLAPALLI
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Patent number: 11447443Abstract: The present invention provides an improved process for preparation of L-threo-(2S,3R)-3-(3,4-dihydroxyphenyl)serine (I) (Droxidopa) and its salts; comprising (a) reaction of the aldehyde compound (III) (as described herein) with Metal complex (II) (as described herein), and (h) hydrolysis of the compound (IV) obtained from step (a) in presence of acid. The present invention also relates to a novel intermediates metal chiral complex (IV) for the preparation of Droxidopa.Type: GrantFiled: March 28, 2017Date of Patent: September 20, 2022Assignee: PIRAMAL PHARMA LIMITEDInventors: Milind Gharpure, Ashutosh Jagtap, Changdev Raut, Nainesh Kansagara, Jaisankar Krishnapillai, Nirmal Kumar Manoharan, Navnath Patil
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Patent number: 11401273Abstract: The present invention relates to an improved asymmetric synthesis of azaspiro or diazaspiro compound (hereafter referred to as the compound 5, (5A) or (5N)) or their pharmaceutically acceptable salts and derivatives; through the formation of intermediate compounds 4, (4A) or (4N) respectively. The process comprises an unusual substrate specific highly diastereoselective as well as enantio-enriched 1-substituted 2-azaspiro[3.3]heptane or 1-substituted 2-diazaspiro[3.3]heptane compounds with high diastereoselectivity by addition of a cyclobutane carboxylate anion to a Davis-Ellman's imine, followed by reduction and cyclisation resulting in the selective formation of azaspiro or diazaspiro intermediate compound 4, (4A) or (4N); which on subsequently removing the sulfinyl group provides corresponding azaspiro or diazaspiro compound 5, (5A) or (5N) respectively.Type: GrantFiled: November 19, 2019Date of Patent: August 2, 2022Assignee: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy Leleti, Yogesh Waman, Priya Kallure, Zubeda Begum, Thumban Divya, Kumara Swamy Nalivela, Saurabh Vijay, Paranjay Parikh, Sharadsrikar Kotturi, Chirag Patel, Krishna Nayak, Kasimraza Baharooni, Vinkal Zalavadiya
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Publication number: 20220185788Abstract: The present invention relates to an improved process for the preparation of N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)octanamide (A), which is known as ELIGLUSTAT and its pharmaceutically acceptable salts, comprising the formation of novel intermediate metal complex (III), which on hydrolysis in presence of acid provides amine compound (IV) (as described herein), which is treated with pyrrolidine and subsequently reduced to convert into Eliglustat (A).Type: ApplicationFiled: March 19, 2020Publication date: June 16, 2022Applicant: PIRAMAL PHARMA LIMITEDInventors: Venkataramana Rao RAO, Sharadsrikar KOTTURI, Abdul BASITH, Ramesh Babu BANDI, Manoj Kumar MANDADI
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Patent number: 11312740Abstract: The present invention relates to an industrially feasible and economically viable process for preparation of SGLT2 inhibitors of formula X in significantly high yield and purity.Type: GrantFiled: May 9, 2018Date of Patent: April 26, 2022Assignee: PIRAMAL PHARMA LIMITEDInventors: Milind Gharpure, Sanjay Kumar Sharma, Sandesh Vishwasrao, Prasad Vichare, Dipak Varal
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Patent number: 11299455Abstract: The present invention relates to an improved process for diastereoselective synthesis of vicinal diamines (1). The process involves highly regio- and diastereoselective addition of 2-azaallyl anions (4) to N-tert-butanesulfinylimines (5) to produce vicinal diamines (1).Type: GrantFiled: July 11, 2019Date of Patent: April 12, 2022Assignee: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy Leleti, Sharadsrikar Kotturi, Kumara Swamy Nalivela, Chirag Patel, Poojabahen Raval, Vinkal Zalavadiya
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Patent number: 11279668Abstract: The present invention relates to an improved asymmetric synthesis of alpha-(diarylmethyl) alkyl amines (hereafter referred to as the compound (1)) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual substrate specific regioselective lithiation of alpha-diarylmethanes. followed by its highly diastereoselective addition to N-tert-butanesulfinylimines resulting in the selective formation of chiral alpha-(diarylmethyl) alkyl amines 4 and chiral amine 5; which on subsequently removing the sulfinyl group provides corresponding alpha-(diarylmethyl) alkyl amines (1) or relative chiral amines (1?).Type: GrantFiled: March 20, 2019Date of Patent: March 22, 2022Assignee: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy Leleti, Sharadsrikar Kotturi, Yogesh Waman, Chirag Patel, Rajesh Shenoy
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Patent number: 11279672Abstract: The present invention relates to an improved asymmetric synthesis of alpha-branched amines (hereafter referred to as the compound) and relative chiral amines (1?) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual substrate specific regioselective ortho lithiation of substituted arene compounds, followed by its highly diastereoselective addition to N-tert-butanesulfinylimines resulting in the selective formation of alpha-branched sulfinyl amine and chiral amine; which on subsequently removing the sulfinyl group provides corresponding alpha-branched amines or relative chiral amines (1?).Type: GrantFiled: April 17, 2019Date of Patent: March 22, 2022Assignee: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy Leleti, Sharadsrikar Kotturi, Yogesh Waman, Chirag Patel, Aditya Patwa, Rajesh Shenoy
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Publication number: 20220073454Abstract: The present invention relates to an improved process for diastereoselective synthesis of vicinal diamines (1). The process involves highly regio- and diastereoselective addition of 2-azaallyl anions (4) to N-tert-butanesulfinylimines (5) to produce vicinal diamines (1).Type: ApplicationFiled: July 11, 2019Publication date: March 10, 2022Applicant: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy LELETI, Sharadsrikar KOTTURI, Kumara Swamy NALIVELA, Chirag PATEL, Poojabahen RAVAL, Vinkal ZALAVADIYA
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Publication number: 20220041609Abstract: The present invention relates to an improved asymmetric synthesis of azaspiro or diazaspiro compound (hereafter referred to as the compound 5, (5A) or (5N)) or their pharmaceutically acceptable salts and derivatives; through the formation of intermediate compounds 4, (4A) or (4N) respectively. The process comprises an unusual substrate specific highly diastereoselective as well as enantio-enriched 1-substituted 2-azaspiro[3.3]heptane or 1-substituted 2-diazaspiro[3.3]heptane compounds with high diastereoselectivity by addition of a cyclobutane carboxylate anion to a Davis-Ellman's imine, followed by reduction and cyclisation resulting in the selective formation of azaspiro or diazaspiro intermediate compound 4, (4A) or (4N); which on subsequently removing the sulfinyl group provides corresponding azaspiro or diazaspiro compound 5, (5A) or (5N) respectively.Type: ApplicationFiled: November 19, 2019Publication date: February 10, 2022Applicant: PIRAMAL PHARMA LIMITEDInventors: Rajender Reddy LELETI, Yogesh WAMAN, Priya KALLURE, Zubeda BEGUM, Thumban DIVYA, Kumara Swamy NALIVELA, Saurabh VIJAY, Paranjay PARIKH, Sharadsrikar KOTTURI, Chirag PATEL, Krishna NAYAK, Kasimraza BAHAROONI, Vinkal ZALAVADIYA
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Publication number: 20220000787Abstract: The present invention relates to a delayed-release pharmaceutical composition comprising an active ingredient prednisone and one or more pharmaceutical excipient(s). The invention further relates to a process for preparation of said pharmaceutical composition for oral administration, particularly a tablet, comprising prednisone with one or more pharmaceutically acceptable excipient(s), wherein the tablet is formulated using a coating technique which has a significant impact on drug release.Type: ApplicationFiled: June 30, 2021Publication date: January 6, 2022Applicant: PIRAMAL PHARMA LIMITEDInventors: Umesh V. BARABDE, Narendra PATEL, Dinesh M. MORKHADE, Bhushan Santoshrao BHOYAR
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Patent number: 11192848Abstract: The present invention provides an improved process for preparation of the L-threo-(2S,3R)-3-(3 4-dihydroxyphenyl)serine (I) or a salt thereof, which is known as Droxidopa; comprising (a) recovery of the by-product compound (V) (as described herein) from the crude compound (I), and (b) recycling and re-use it for the preparation of droxidopa. Accordingly, the present invention relates to an improved economical process for the preparation of L-threo-(2S,3R)-3-(3.4-dihydroxyphenyl)serine (I) or its pharmaceutically acceptable salts; wherein the process relates to recovery and recycling of the by-product compound (V) and also to re-use it for the preparation of droxidopa.Type: GrantFiled: January 3, 2019Date of Patent: December 7, 2021Assignee: PIRAMAL PHARMA LIMITEDInventors: Milind Gharpure, Ashutosh Jagtap, Changdev Raut, Navnath Patil, Prashant Ladkat, Jaisankar Krishnapillai, Nirmal Kumar Manoharan, Kumaravel Kandasamy
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Publication number: 20210371992Abstract: The present invention provides to a simple and efficient electrochemical organic reaction setup, particularly to carry out electrolysis reactions in chemistry laboratory and methods for performing the same with good yield and less impurity formation using the instantly presented device. Accordingly, the present invention relates to an electrochemical organic reaction setup as shown in fig. A-J comprising (a) Current source (6), (b) Reaction vessel or vial assembly set up comprising reaction vessel or vial (3), anode (1) cathode (2), Guard tube (8), alligator clip (5) and (c) Reaction mixture (4); for use in electrochemical reactions involving coupling between carbocyclic or heterocyclic rings and also in ring formation reactions between two or more moieties.Type: ApplicationFiled: November 20, 2019Publication date: December 2, 2021Applicant: PIRAMAL PHARMA LIMITEDInventors: Tanay GHOSAL, Vishal NAGAR, Sharadsrikar KOTTURI, Sasikumar KUTTAAPPAN
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Publication number: 20210229063Abstract: The present invention provides an improved photochemical rector assembly device, particularly a light emitting diode (LED) based small photochemical reactor and methods for performing the photochemical transformations using the instantly presented device. Accordingly, the present invention relates to an improved photochemical transformation reaction by exposing the reaction mixture to a photochemical rector device as shown in fig. A-G, comprising of (i) light emitting diode (LED) panel (1), (ii) Aluminium based heat sink, and (iii) cooling fan.Type: ApplicationFiled: August 19, 2019Publication date: July 29, 2021Applicant: PIRAMAL PHARMA LIMITEDInventors: Tushar PATEL, Sharadsrikar KOTTURI, Sasikumar KUTTAPPAN
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Publication number: 20210171442Abstract: The present invention provides an improved process for the preparation of 3-(4-chlorophenyl)-3-cyanopropanoic acid (compound (A)) and further its transformation to Baclofen (I). The process comprises reaction of compound (II) with Glyoxylic acid to obtain 3-(4-chlorophenyl)-3-cyanoacrylic acid (III); followed by the ‘in-situ’ reduction of (III) in the presence of a reducing agent to provide the compound (A). Alternatively, the compound (A) is obtained by the process comprising reacting 2-(4-chlorophenyl)acetonitrile (II) with haloacetic acid (IV) in the presence of a base. The compound 3-(4-chlorophenyl)-3-cyanopropanoic acid (A) undergoes hydrogenation in the presence of a metal catalyst and ammonia solution to provide Baclofen (I).Type: ApplicationFiled: January 20, 2021Publication date: June 10, 2021Applicant: PIRAMAL PHARMA LIMITEDInventors: Ashutosh JAGTAP, Milind GHARPURE, Navnath SHINDE, Navnath PATIL, Changdev RAUT, Dhileepkumar KRISHNAMURTHY