Patents Assigned to Pitman-Moore, Inc.
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Patent number: 5344018Abstract: A dispensing package assembly useful for dispensing a predetermined amount of a fluent material comprises a relatively stiff base sheet, a blister overlay appended to the overlay and a dispenser pouch housed within the confines of the overlay and the sheet. The blister overlay having a main cavity and a secondary cavity includes a dispenser depression, preferably in the shape of a thumb indention, which protrudes downward into the main cavity. A shearing depression extending laterally through the secondary cavity defines an area of reduced depth within the secondary cavity. The main body of the pouch is located within the overlay main cavity having a dispensing channel or passageway extending therefrom beneath the shearing depression and into the secondary cavity.Type: GrantFiled: June 1, 1992Date of Patent: September 6, 1994Assignee: Pitman-Moore, Inc.Inventor: Jane E. Severin
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Patent number: 5286749Abstract: A topical liquid formulation for treating lice or head infection is disclosed. The formulation contains active ingredients such as deltamethrin or permethrin in a lower alkyl ether of glycol.Type: GrantFiled: October 12, 1990Date of Patent: February 15, 1994Assignee: Pitman-Moore Inc.Inventors: Peter J. Kieran, Robert B. Townsend
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Patent number: 5266477Abstract: Monoclonal antibodies are provided which differentiate between native and modified sequence proteins. Also provided are methods for using monoclonal antibodies to determine the relative amount of native and modified sequence proteins in a sample.Type: GrantFiled: February 2, 1990Date of Patent: November 30, 1993Assignee: Pitman-Moore, Inc.Inventors: David K. Howard, Anne M. Gill
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Patent number: 5236954Abstract: A liquid phase composition of a pyrethroid in concentrations greater than 50% w/w that may be used as a basis for other pyrethroid containing formulations in physical phases other than the liquid phase is described. A method of treatment utilizing the composition on domestic mammal is also described. The composition can be applied as a small dose to a localized region of the animal's body which is then delivered to relatively all of the animal's body surface by migration of the pyrethroid.Type: GrantFiled: May 30, 1991Date of Patent: August 17, 1993Assignee: Pitman-Moore, Inc.Inventors: Julie G. Gladney, David S. Seymour, Jack I. Shugart, Robert G. Pennington
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Patent number: 5219572Abstract: A controlled release delivery device for macromolecular proteins which comprises a water-soluble outer capsule completely surrounding an inner compartment containing a plurality of non-uniform beadlets. The beadlets comprise a rupturable wax shell which completely surrounds a core matrix containing the macromolecular proteins and optional "core agents" such as excipients, stabilizers, binders, surfactants, preservatives, or mixtures thereof, and the like.The water-soluble outer capsule dissolves when the device is administered to an animal and simultaneously exposes substantially all of the beadlets to an aqueous environment. Each beadlet absorbs fluid from the environment and separately ruptures over a prolonged period thus delivering the macromolecular protein to the animal.Type: GrantFiled: July 25, 1991Date of Patent: June 15, 1993Assignee: Pitman-Moore, Inc.Inventors: Kallidaikurichi N. Sivaramakrishnan, Lindy F. Miller
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Patent number: 5137872Abstract: Human Growth Hormone-Releasing Factor (hGRF) analogs having the sequence [Pro.sup.0, X.sup.15, Y.sup.27 ]-hGRF(1-A)-B, wherein X is selected from the group consisting of Ala and Gly, Y is selected from the group consisting of Ile, Leu, Val, Nle and Met, A has a value from 29-44, and B is NH.sub.2, OH or COOH are synthesized and administered to animals to stimulate the release of Growth Hormone (GH).Type: GrantFiled: September 18, 1989Date of Patent: August 11, 1992Assignee: Pitman-Moore, Inc.Inventors: James E. Seely, Hsi Meng
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Patent number: 5135493Abstract: A strip carriage adapter and corresponding strip cartridge which allows conversion of a handgun-type implanter which uses cylinder-type pellet cartridges to one which uses strip-type pellet cartridges.Type: GrantFiled: September 10, 1990Date of Patent: August 4, 1992Assignee: Pitman-Moore, Inc.Inventor: Mark Peschke
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Patent number: 5122512Abstract: Porcine somatotropin (pST) and dietary lysine are administered in combination in dosages of from about 1-20 mg/swine/day pST and from about 0.9-1.6% by weight dietary lysine to synergistically promote growth, improve weight gain and increase feed utilization efficiency in swine. Administration of the compounds is conveniently accomplished by (1) administering porcine somatotropin (pST) to swine using conventional methods such as injections or implants and (2) feeding the swine a feed composition containing the lysine.Type: GrantFiled: September 12, 1988Date of Patent: June 16, 1992Assignee: Pitman-Moore, Inc.Inventor: Brian R. Schricker
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Patent number: 5109121Abstract: A method for recovering a recombinant protein from a protein solution containing high molecular weight contaminating proteins by directly adding Group IIA metal salts to the solution in amounts sufficient to selectively precipitate the high molecular weight protein contaminants is disclosed.The high molecular weight precipitates are removed and the solution is further processed to remove low molecular weight contaminating proteins and other non-protein contaminants. The recombinant protein is subsequently recovered and further processed to produce a protein composition suitable for its intended use.Type: GrantFiled: October 9, 1990Date of Patent: April 28, 1992Assignee: Pitman-Moore, Inc.Inventors: Galina Blum, Ren-der Yang, Eun K. Lee
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Patent number: 5079230Abstract: The present invention provides a stable and bioactive somatotropin which has its small-loop sulfhydryl groups derivatized and a method for producing the small-loop derivatized somatotropin. The small-loop derivatized somatotoropin is stable during long term storage, i.e. it forms very few dimers, oligomers, and aggregates which inactivate the somatotropin, and has a bioactivity equal to or greater than that of the non-derivatized somatotropin.Type: GrantFiled: September 12, 1988Date of Patent: January 7, 1992Assignee: Pitman-Moore, Inc.Inventors: Zafar I. Randawa, James F. Seely
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Patent number: 5047511Abstract: A method for recovering a recombinant protein from a protein solution containing high molecular weight contaminating proteins by directly adding a flocculant to the solution in amounts sufficient to selectively precipitate the high molecular weight protein contaminants is disclosed.The high molecular weight precipitates are removed and the solution is further processed to remove low molecular weight contaminating proteins and other non-protein contaminants. The recombinant protein is subsequently recovered and further processed to produce a protein composition suitable for its intended use.Type: GrantFiled: August 28, 1989Date of Patent: September 10, 1991Assignee: Pitman-Moore, Inc.Inventor: Vikram P. Mehrotra
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Patent number: 5036047Abstract: A method for preventing conception in mammals which includes administering to the mammals a composition containing (1) free LHRH or its analog and (2) an immunogenic conjugate between LHRH or its analog and a carrier protein. Free LHRH or its analog acts to prevent conception in the mammal during the period from administration to about 6 weeks; the immunogenic conjugate acts to prevent conception during the period from about 6 weeks after administration until the LHRH antibodies formed in response to the conjugate are metabolized, generally about 0.5-2 years.Type: GrantFiled: September 29, 1988Date of Patent: July 30, 1991Assignee: Pitman-Moore, Inc.Inventor: Abdus S. Mia
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Patent number: 5028591Abstract: The proteins somatotropin and prolactin are administered to animals in amounts of from about 0.1-24 mg/animal/day to stimulate the immune system by increasing the production of macrophages and augmenting the oxidative metabolism of macrophages. The activated macrophages combat infectious disease causing agents such as viruses, bacteria, fungi, protozoa, helminths, and the like and thus are effective in preventing and treating diseases caused by those agents.Type: GrantFiled: March 9, 1989Date of Patent: July 2, 1991Assignee: Pitman-Moore, Inc.Inventors: Carl K. Edwards, III, Libby M. Yunger
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Patent number: 5017560Abstract: Porcine prolactin (pPRL) is administered to poultry in dosages of from about 1-500 ug/kg/day, preferably 10-100 ug/kg/day, to promote growth by improving the rate of weight gain and/or increasing feed utilization efficiency.Type: GrantFiled: November 6, 1987Date of Patent: May 21, 1991Assignee: Pitman-Moore, Inc.Inventors: Chauncey D. Baldwin, Brian R. Shricker, Richard E. Ivy
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Patent number: 5008244Abstract: Somatotropin is administered to food producing animals in the finishing stage of growth to increase fertility by increasing embryonic survival and litter size during the reproductive stage of growth.Type: GrantFiled: May 15, 1989Date of Patent: April 16, 1991Assignee: Pitman-Moore, Inc.Inventors: Lindy F. Miller, Peter J. Thomford
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Patent number: 5004488Abstract: High purity fused silica particles are made by heating relatively low density silica flour in a high temperature flame. The silica flour feed rate, flame temperature, and collection zone temperature are adjusted to produce an aggregate of surface-bonded fused silica particles. The aggregate is shaped like a honeycomb and can be ground autogenously without introducing impurities into the final product.Type: GrantFiled: March 20, 1989Date of Patent: April 2, 1991Assignee: Pitman-Moore, Inc.Inventors: Vikram P. Mehrotra, Ray E. Barker
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Patent number: 4988798Abstract: A method for recovering a recombinant protein from a protein solution containing high molecular weight contaminating proteins by directly adding Group IIA metal salts to the solution in amounts sufficient to selectively precipitate the high molecular weight protein contaminants is disclosed.The high molecular weight precipitates are removed and the solution is further processed to remove low molecular weight contaminating proteins and other non-protein contaminants. The recombinant protein is subsequently recovered and further processed to produce a protein composition suitable for its intended use.Type: GrantFiled: January 22, 1990Date of Patent: January 29, 1991Assignee: Pitman-Moore, Inc.Inventors: Galina Blum, Ren-der Yang, Eun K. Lee
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Patent number: 4976963Abstract: A pelletized feed supplement is supplied which effectively increases productivity of animals fed high acid producing diets. The pelletized feed supplement can also be used to neutralize stomach acid of humans and to maintain a proper electrolyte balance. A method is taught of producing the pelletized feed supplement which results in a buffering agent which is dissolved gradually, and has a high buffering capacity.Type: GrantFiled: October 2, 1989Date of Patent: December 11, 1990Assignee: Pitman-Moore, Inc.Inventors: Brian R. Schricker, Vikram P. Mehrotra
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Patent number: 4902711Abstract: 6' Carbamate esters of zearalanol and its derivatives are used to promote growth in ruminants. The compounds have the structural formula: ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, are H, X, or COX, where X is an alkyl group having from 1-6 carbon atoms; and R is NH-Y, where Y is an alkyl group having from 1-6 carbon atoms or a five-membered or six-membered ring; N(C.sub.n H.sub.2n+1).sub.2, where n is an integer from 1 to 6; or a five-membered or six-membered heterocyclic ring having one N heteroatom and up to one other heteroatom selected from the group consisting of N, S, and O heteroatoms.Type: GrantFiled: January 19, 1988Date of Patent: February 20, 1990Assignee: Pitman-Moore, Inc.Inventor: Edward B. Hodge
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Patent number: 4886899Abstract: Substituted resorcyclic acid esters having the structural formula: ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, are H, X, or COX, where X is an alkyl group having from 1-6 carbon atoms; and R.sub.3 is an alkyl group having from 1-12 carbon atoms are synthesized and used as housefly chemosterilants which reduce housefly fecundity.Type: GrantFiled: July 5, 1988Date of Patent: December 12, 1989Assignee: Pitman-Moore, Inc.Inventor: Martin J. Jacobs