Abstract: Solid state forms of Palbociclib dimesylate, processes for preparation thereof and use thereof for preparation of Palbociclib are disclosed.

Abstract: Solid state forms of Palbociclib dimesylate, processes for preparation thereof and use thereof for preparation of Palbociclib are disclosed.

Abstract: Solid state forms of Palbociclib dimesylate, processes for preparation thereof and use thereof for preparation of Palbociclib are disclosed.

Abstract: There are disclosed certain novel imidazo(2,1-b)thiazoles, their physiologically acceptable acid addition--or quaternary ammonium salts and a process for their preparation. Said compounds show a good anti-diabetic activity.

Abstract: Compounds of formula (I): ##STR1## [in which: Z represents a group of formula ##STR2## R represents a hydrogen atom, a 1-pyridyl group or a group of formula --YR' (in which: R' represents an alkyl group, an alkanoyl group a carbamoyl group or a heterocyclic group; and Y represents an oxygen or a sulphur atom);X represents a hydrogen atom or a hydroxy group; andthe .alpha.-amino acid moiety is in the D(-) configuration]are prepared by silylating the corresponding compound having an amino group at the 6-penam or 7-cepham position, acylating the silylated compound with D(-)-p-hydroxyphenglycyl chloride hydrochloride or D(-)-p-hydroxyphenylglycyl chloride hydrochloride and then hydrolyzing the acylated product. By carrying out the reaction in the presence of an N-alkylpyrrolidone, it is possible to improve the yields and purity of the desired product.

Abstract: Pharmaceutical compositions containing certain imidazo(2,1-b)thiazoles, their physiologically acceptable acid addition- or quaternary ammonium salts, and a process for reducing blood sugar levels by the administration thereof.

Abstract: Benzylcyano-acids and amides useful as intermediates in the preparation of pharmaceutically valuable 2,4-diamino-5-benzyl pyrimidines.