Patents Assigned to PLAS-FREE LTD
  • Patent number: 11975132
    Abstract: The presently disclosed subject-matter provides specific compositions, conjugates, device, kits and systems for depleting fibrinolytic agents from biological fluids. The presently disclosed subject-matter further relates to the resulting biological fluid products that are devoid in fibrinolytic activity, therapeutic methods and uses thereof. The conjugates comprise a particle, at least one linker and at least one amino acid, derivative thereof or analog thereof being at least one of 4-(aminomethyl)-cyclo-hexane-carboxylic acid (tranexamic acid), epsilon-amino caproic acid, lysine, cyclohexanecarboxylic acid and 4-methyl-cyclohexanecarboxylic acid. A plurality of different conjugates (e.g. differing in particle size or type of linker) can be used.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: May 7, 2024
    Assignee: PLAS-FREE LTD
    Inventors: Abd Alrauf Hijazi, Zeev Dvashi
  • Publication number: 20230390474
    Abstract: The present invention pertains to present invention relates to a device comprising conjugate/s, and uses thereof in depleting at least one amine, specifically ammonia from body fluids. The present disclosure further provides systems, apparatus, conjugates, plurality of conjugates, and methods. More specifically, the conjugate comprising a particle bonded to at least one linker comprising a chain of n carbon atoms covalently bonded to m carbonyl groups, and at least one trapping agent A covalently bonded to the mth carbonyl group, (Formula I) wherein, n is an integer within the range of 5 to 15, and m is an integer within the range of 5 to 10, wherein trapping agent A is characterized by having the ability to capture or bind amine. In some optional embodiments, the amine is at least one of methylamine, dimethylamine or trimethylamine.
    Type: Application
    Filed: December 9, 2021
    Publication date: December 7, 2023
    Applicant: PLAS-FREE LTD
    Inventors: Zeev DVASHI, Nuha HIJAZI
  • Patent number: 11491186
    Abstract: The present invention provides therapeutic products with decreased fibrinolytic activity of t-PA-deficient and/or plasminogen-deficient blood products, as well as compositions, kits and methods using the same in treating bleeding associated with hereditary or acquired bleeding disorders. The invention further provides extracorporeal apparatus for blood or blood products Plasmapheresis aimed to prevent or treat bleeding disorders.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: November 8, 2022
    Assignee: PLAS-FREE LTD
    Inventors: Abd Alrauf Hijazi, Muhamed Higazi