Patents Assigned to Platco Technologies (Proprietary) Limited
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Patent number: 7956208Abstract: This invention relates a method for the preparation of platinum(II) oxalato complexes from their dihalogenoplatinum(II) precursors having either neutral monodentate or bidentate non-leaving co-ligands. Of particular interest is oxaliplatin. The method includes the step of reacting a halogenoplatinum(II) complex containing a neutral monodentate or bidentate ligand with an oxalate in a non-aqueous solvent or a mixed solvent system. The mixed solvent system is solvent mixture containing a non-aqueous solvent and water. According to the present invention, the non-aqueous solvent is an alcohol.Type: GrantFiled: January 30, 2007Date of Patent: June 7, 2011Assignee: Platco Technologies (Proprietary) LimitedInventor: Jan Gysbert Hermanus Du Preez
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Patent number: 7888523Abstract: This invention relates to a method for the preparation of a platinum(II) complex containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a halogenoplatinum complex containing a neutral bidentate ligand with an oxalate salt in a solvent, wherein more than 1 g/L of the oxalate salt is soluble in the solvent. The invention also relates to new platinum(II) complexes.Type: GrantFiled: July 23, 2009Date of Patent: February 15, 2011Assignee: Platco Technologies (Proprietary) LimitedInventor: Jan Gysbert Hermanus Du Preez
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Patent number: 7888390Abstract: The invention relates to a method for the preparation of platinum (II) complexes, in particular dicarboxylatoplatinum (II) complexes containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a bis-dicarboxylatoplatinate (II) species with a suitable neutral bidentate ligand to form a neutral dicarboxylatoplatinum (II) complex and, if necessary, recrystallizing the product to form a pure dicarboxylatoplatinum (II) complex containing a neutral bidentate ligand. The invention also relates to a method for producing a bis-dicarboxylatoplatinate (II) species, and to new platinum (II) complexes that can be made by the method of the invention.Type: GrantFiled: June 24, 2009Date of Patent: February 15, 2011Assignee: Platco Technologies (Proprietary) LimitedInventor: Jan Gysbert Hermanus Du Preez
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Publication number: 20110021483Abstract: Provided are nitroplatinum(IV) complexes containing a bidentate dicarboxylate ligand (e.g., oxalate) which maybe useful treating various forms of proliferative diseases, such as cancer. In some instances the platinum(IV) complexes are relatively stable and may be suitable for oral administration. Also provided are methods of treatment, as well as kits and unit dosages.Type: ApplicationFiled: June 18, 2008Publication date: January 27, 2011Applicant: PLATCO TECHNOLOGIES (PROPRIETARY) LIMITEDInventor: Jan Gysbert Hermanus Du Preez
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Publication number: 20100184854Abstract: Provided are nitroplatinum(IV) complexes which may be useful treating various forms of proliferative diseases, such as cancer. In some instances the platinum(IV) complexes are relatively stable and may be suitable for oral administration. Also provided are methods of treatment, as well as kits and unit dosages.Type: ApplicationFiled: December 11, 2009Publication date: July 22, 2010Applicant: Platco Technologies (Proprietary) LimitedInventor: Jan Gysbert Hermanus DU PREEZ
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Publication number: 20090312417Abstract: The invention relates to a method for the preparation of platinum (II) complexes, in particular dicarboxylatoplatinum (II) complexes containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a bis-dicarboxylatoplatinate (II) species with a suitable neutral bidentate ligand to form a neutral dicarboxylatoplatinum (II) complex and, if necessary, recrystallising the product to form a pure dicarboxylatoplatinum (II) complex containing a neutral bidentate ligand. The invention also relates to a method for producing a bis-dicarboxylatoplatinate (II) species, and to new platinum (II) complexes that can be made by the method of the invention.Type: ApplicationFiled: June 24, 2009Publication date: December 17, 2009Applicant: Platco Technologies (Proprietary) LimitedInventor: Jan Gysbert Hermanus Du Preez
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Publication number: 20090299085Abstract: This invention relates to a method for the preparation of a platinum(II) complex containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a halogenoplatinum complex containing a neutral bidentate ligand with an oxalate salt in a solvent, wherein more then 1 g/L of the oxalate salt is soluble in the solvent. The invention also relates to new platinum(II) complexes.Type: ApplicationFiled: July 23, 2009Publication date: December 3, 2009Applicant: Platco Technologies (Proprietary) LimitedInventor: Jan Gysbert Hermanus DU PREEZ
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Publication number: 20090281319Abstract: This invention relates a method for the preparation of platinum(II)oxalato complexes from their dihalogenoplatinum(II) precursors having either neutral monodentate or bidentate non-leaving co-ligands. Of particular interest is oxaliplatin. The method includes the step of reacting a halogenoplatinum(II) complex containing a neutral monodentate or bidentate ligand with an oxalate in a non-aqueous solvent or a mixed solvent system. The mixed solvent system is solvent mixture containing a non-aqueous solvent and water. According to the present invention, the non-aqueous solvent is an alcohol.Type: ApplicationFiled: January 30, 2007Publication date: November 12, 2009Applicant: Platco Technologies (Proprietary) LimitedInventor: Jan Gysbert Hermanus Du Preez
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Patent number: 7589225Abstract: This invention relates to a method for the preparation of a platinum(II) complex containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a halogenoplatinum complex containing a neutral bidentate ligand with an oxalate salt in a solvent, wherein more than 1 g/L of the oxalate salt is soluble in the solvent. The invention also relates to new platinum(II) complexes.Type: GrantFiled: March 7, 2005Date of Patent: September 15, 2009Assignee: Platco Technologies (Proprietary) LimitedInventor: Jan Gysbert Hermanus Du Preez
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Patent number: 7576126Abstract: The invention relates to a method for the preparation of platinum (II) complexes, in particular dicarboxylatoplatinum (II) complexes containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a bis-dicarboxylatoplatinate (II) species with a suitable neutral bidentate ligand to form a neutral dicarboxylatoplatinum (II) complex and, if necessary, recrystallising the product to form a pure dicarboxylatoplatinum (II) complex containing a neutral bidentate ligand. The invention also relates to a method for producing a bis-dicarboxylatoplatinate (II) species, and to new platinum (II) complexes that can be made by the method of the invention.Type: GrantFiled: November 24, 2004Date of Patent: August 18, 2009Assignee: Platco Technologies (Proprietary) LimitedInventor: Jan Gysbert Hermanus Du Preez
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Publication number: 20070167643Abstract: The invention relates to a method for the preparation of platinum (II) complexes, in particular dicarboxylatoplatinum (II) complexes containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a bis-dicarboxylatoplatinate (II) species with a suitable neutral bidentate ligand to form a neutral dicarboxylatoplatinum (II) complex and, if necessary, recrystallising the product to form a pure dicarboxylatoplatinum (II) complex containing a neutral bidentate ligand. The invention also relates to a method for producing a bis-dicarboxylatoplatinate (II) species, and to new platinum (II) complexes that can be made by the method of the invention.Type: ApplicationFiled: November 24, 2004Publication date: July 19, 2007Applicant: PLATCO TECHNOLOGIES (PROPRIETARY) LIMITEDInventor: Jan Gysbert Du Preez