Abstract: The invention relates to agglutination assays and related kits, reagents and devices. In particular methods of assaying small analytes having few epitopes are disclosed, by means of using hub moieties to which multiple analytes may be bound by a first epitope, together with a further moiety capable of binding a second analyte epitope and which is also capable of binding to a detectable particle. Stable agglutinated complexes may be so formed, which may used as the basis for various assay formats.

Abstract: The invention provides a modified form of saturation assay, which is based on the measurement of a free or unbound labelled reagent fraction (such that there is an increase in signal in the presence of analyte) and employs trapping zones to concentrate said unbound or free labelled fraction to avoid loss of sensitivity. Preferably, the assay is a membrane assay.

Abstract: The present invention provides an agglutination based assay system for determining the presence and/or amount of analyte in a sample comprising a test device having one or more capillary pathways comprising detection regions adapted for non-visual detection of a sample which is releasably engageable with a reader which comprises detection means for detecting the sample at the detection regions in each of said capillary pathways and electronic means for indicating the presence and/or amount of analyte.

Abstract: A sample testing device for testing for the presence of a component of interest in a liquid sample includes: (a) a capillary pathway having an upstream end and a downstream end and incorporating a reagent system capable of causing agglutination with the component; (b) optionally, a control capillary pathway; (c) a sampling region to which the liquid sample is applied and from which the sample is able to enter the upstream ends of the test and control capillaries; (d) a power source; (e) detection arrangements electrically associated with the power source for detecting the presence of liquid at a downstream region of the capillaries; (f) a display operated by the power source for indicating the result of the test; and (g) a signal processor associated with the power source, detection arrangement and display for evaluating the result of the test and providing the result on the display.

Abstract: A sample testing device for testing for the presence of a component of interest in a liquid sample comprises: (a) at least one capillary pathway which has an upstream end and a downstream end and which incorporates a reagent system capable of causing agglutination with said component to be detected (the test capillary); (b) preferably, but optionally, at least one capillary pathway having an upstream end and a downstream end (the control capillary); (c) a sampling region to which the liquid sample is applied and from which the sample is able to enter the upstream ends of the test capillary(s) and if present the control capillary(s); (d) a power source; (c) detection arrangements electrically associated with said power source for detecting the presence of liquid at a downstream region of said testing capillary(s) and if present the control capillary(s); (f) display means operated by said power source for indicating the result of the test; and (g) signal processing means associated with the power source, detect

Abstract: A sample testing device for testing for the presence of a component of interest in a liquid sample comprises: (a) at least one capillary pathway which has an upstream end and a downstream end and which incorporates a reagent system capable of causing agglutination with said component to be detected (the test capillary); (b) preferably, but optionally, at least one capillary pathway having an upstream end and a downstream end (the control capillary); (c) a sampling region to which the liquid sample is applied and from which the sample is able to enter the upstream ends of the test capillary(s) and if present the control capillary(s); (d) a power source; (c) detection arrangements electrically associated with said power source for detecting the presence of liquid at a downstream region of said testing capillary(s) and if present the control capillary(s); (f) display means operated by said power source for indicating the result of the test; and (g) signal processing means associated with the power source, detect

Abstract: The invention provides a modified form of saturation assay, which is based on the measurement of a free or unbound labelled reagent fraction (such that there is an increase in signal in the presence of analyte) and employs trapping zones to concentrate said unbound or free labelled fraction to avoid loss of sensitivity. Preferably, the assay is a membrane assay.

Abstract: The present invention provides an agglutination based assay system for determining the presence and/or amount of analyte in a sample comprising a test device having one or more capillary pathways comprising detection regions adapted for non-visual detection of a sample which is releasably engageable with a reader which comprises detection means for detecting the sample at the detection regions in each of said capillary pathways and electronic means for indicating the presence and/or amount of analyte. Also provided are the individual test device and reader components, and an assay method using the system.

Abstract: The invention relates to agglutination assays and related kits, reagents and devices. In particular methods of assaying small analytes having few epitopes are disclosed, by means of using hub moieties to which multiple analytes may be bound by a first epitope, together with a further moiety capable of binding a second analyte epitope and which is also capable of binding to a detectable particle. Stable agglutinated complexes may be so formed, which may used as the basis for various assay formats.

Abstract: A sample testing device (100) for testing for the presence of a component of interest in a liquid sample comprises: (a) at least one capillary pathway (120) which has an upstream end and a downstream end and which incorporates a reagent system capable of causing agglutination with said component to be detected (the test capillary); (b) preferably, but optionally, at least one capillary pathway (121) having an upstream end and a downstream end (the control capillary); (c) a sampling region (114) to which the liquid sample is applied and from which the sample is able to enter the upstream ends of the test capillary(s) (120) and if present the control capillary(s) (121); (d) a power source (108, 109); (e) detection arrangements (117, 118) electrically associated with said power source (108, 109) for detecting the presence of liquid at a downstream region of said testing capillary(s) (120) and if present the control capillary(s) (121); (f) display means (113) operated by said power source (108, 109) for indicatin