Patents Assigned to Plexera, LLC
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Patent number: 8796003Abstract: This disclosure describes methods and compositions for measuring the binding specificity, kinetics and affinity of kinase inhibitors indirectly using mass sensing analytical techniques, such as SPR, through the competitive displacement of detectable signal-inducing kinase binding molecule. Further provided are methods for preparing such molecules.Type: GrantFiled: August 8, 2012Date of Patent: August 5, 2014Assignee: Plexera, LLCInventors: Ronald P. Dudek, Michael Cicirelli, Timothy C. Parker
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Publication number: 20140185051Abstract: An instrument comprises a semi-circular rail and a driving mechanism. The driving mechanism is attached to a light source mount and a detector mount, and both the light source mount and the detector mount are attached to the semi-circular rail with connectors. Each connector allows the light source mount and detector mount to slide along the rail. The synchronous movement of the light source mount and the detector mount changes the angle of incidence of a light beam from the light source with respect to the plane of the sample surface on the sample stage. An SPR analysis system includes an SPR analysis system control computer program having a graphical user interface and configured to control the operation of an SPR analysis apparatus. According to an embodiment, an SPR data analysis computer program includes an SPR microarray video viewer and a sensorgram generator responsive to the SPR video.Type: ApplicationFiled: January 14, 2014Publication date: July 3, 2014Applicant: Plexera, LLCInventors: Hann-Wen Guan, Shuxin Cong
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Publication number: 20140139837Abstract: An apparatus may include a flow cell for a surface plasmon resonance test apparatus and a fluid delivery system operatively coupled to the flow cell and configured to deliver a plurality of fluids to the flow cell substantially continuously. The fluid delivery system may include two pumps for pumping the fluids.Type: ApplicationFiled: June 26, 2013Publication date: May 22, 2014Applicant: Plexera LLCInventors: Gilbum Kim, Hannwen Guan, Shuxin Cong
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Patent number: 8477313Abstract: An apparatus may include a flow cell for a surface plasmon resonance test apparatus and a fluid delivery system operatively coupled to the flow cell and configured to deliver a plurality of fluids to the flow cell substantially continuously. The fluid delivery system may include two pumps for pumping the fluids.Type: GrantFiled: November 30, 2012Date of Patent: July 2, 2013Assignee: Plexera LLCInventors: Gilbum Kim, Hannwen Guan, Shuxin Cong
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Publication number: 20130088717Abstract: An apparatus may include a flow cell for a surface plasmon resonance test apparatus and a fluid delivery system operatively coupled to the flow cell and configured to deliver a plurality of fluids to the flow cell substantially continuously. The fluid delivery system may include two pumps for pumping the fluids.Type: ApplicationFiled: November 30, 2012Publication date: April 11, 2013Applicant: Plexera LLCInventors: Gilbum Kim, Hannwen Guan, Shuxin Cong
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Publication number: 20130003062Abstract: Instruments and methods relating to surface plasmon imaging are described. An instrument comprises a semi-circular rail and a driving mechanism. The driving mechanism is attached to a light source mount and a detector mount, and both the light source mount and the detector mount are attached to the semi-circular rail with connectors. Each connector allows the light source mount and detector mount to slide along the rail. The synchronous movement of the light source mount and the detector mount changes the angle of incidence of a light beam from the light source with respect to the plane of the sample surface on the sample stage.Type: ApplicationFiled: August 23, 2012Publication date: January 3, 2013Applicant: PLEXERA LLCInventors: HANN-WEN GUAN, SHUXIN CONG
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Patent number: 8325346Abstract: An apparatus may include a flow cell for a surface plasmon resonance test apparatus and a fluid delivery system operatively coupled to the flow cell and configured to deliver a plurality of fluids to the flow cell substantially continuously. The fluid delivery system may include two pumps for pumping the fluids.Type: GrantFiled: January 9, 2012Date of Patent: December 4, 2012Assignee: Plexera LLCInventors: Gibum Kim, Hannwen Guan, Shuxin Cong
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Patent number: 8263377Abstract: This disclosure describes methods and compositions for measuring the binding specificity, kinetics and affinity of kinase inhibitors indirectly using mass sensing analytical techniques, such as SPR, through the competitive displacement of detectable signal-inducing kinase binding molecule. Further provided are methods for preparing such molecules.Type: GrantFiled: April 2, 2008Date of Patent: September 11, 2012Assignee: Plexera, LLCInventors: Ronald P Dudek, Michael Cicirelli, Timothy C Parker
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Patent number: 8264691Abstract: Instruments and methods relating to surface plasmon imaging are described. An instrument comprises a semi-circular rail and a driving mechanism. The driving mechanism is attached to a light source mount and a detector mount, and both the light source mount and the detector mount are attached to the semi-circular rail with connectors. Each connector allows the light source mount and detector mount to slide along the rail. The synchronous movement of the light source mount and the detector mount changes the angle of incidence of a light beam from the light source with respect to the plane of the sample surface on the sample stage.Type: GrantFiled: December 1, 2010Date of Patent: September 11, 2012Assignee: Plexera, LLCInventors: Hann-Wen Guan, Shuxin Cong
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Publication number: 20120154818Abstract: An apparatus may include a flow cell for a surface plasmon resonance test apparatus and a fluid delivery system operatively coupled to the flow cell and configured to deliver a plurality of fluids to the flow cell substantially continuously. The fluid delivery system may include two pumps for pumping the fluids.Type: ApplicationFiled: January 9, 2012Publication date: June 21, 2012Applicant: PLEXERA LLCInventors: Gibum Kim, Hannwen Guan, Shuxin Cong
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Publication number: 20120115748Abstract: An article, process, and method for surface plasmon resonance plates are described. A substrate is covered with a thin metal film onto which a second thin metal film is deposited. The surface of the second thin metal film is converted to the metal oxide which is used to covalently bond organosilanes to the surface. Reactive organosilanes containing terminal bonding groups are arranged in a plurality of spots that are surrounded by inert organosilanes. Biomolecule attachment to the binding group is detected or measured from surface plasmon signals from the first thin metal film.Type: ApplicationFiled: December 27, 2011Publication date: May 10, 2012Applicant: PLEXERA LLCInventors: Nicholas Adam WOLF, Danliang JIN, Anna BARKLUND, Raluca DINU
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Patent number: 8107082Abstract: An apparatus may include a flow cell for a surface plasmon resonance test apparatus and a fluid delivery system operatively coupled to the flow cell and configured to deliver a plurality of fluids to the flow cell substantially continuously. The fluid delivery system may include two pumps for pumping the fluids.Type: GrantFiled: July 21, 2011Date of Patent: January 31, 2012Assignee: Plexera LLCInventors: Gilbum Kim, Hannwen Guan, Shuxin Cong
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Patent number: 8094315Abstract: An article, process, and method for surface plasmon resonance plates are described. A substrate is covered with a thin metal film onto which a second thin metal film is deposited. The surface of the second thin metal film is converted to the metal oxide which is used to covalently bond organosilanes to the surface. Reactive organosilanes containing terminal bonding groups are arranged in a plurality of spots that are surrounded by inert organosilanes. Biomolecule attachment to the binding group is detected or measured from surface plasmon signals from the first thin metal film.Type: GrantFiled: December 8, 2008Date of Patent: January 10, 2012Assignee: Plexera LLCInventors: Nicholas Adam Wolf, Danliang Jin, Anna Barklund, Raluca Dinu
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Patent number: 8004669Abstract: An apparatus may include a flow cell for a surface plasmon resonance test apparatus and a fluid delivery system operatively coupled to the flow cell and configured to deliver a plurality of fluids to the flow cell substantially continuously. The fluid delivery system may include two pumps for pumping the fluids.Type: GrantFiled: December 18, 2008Date of Patent: August 23, 2011Assignee: Plexera LLCInventors: Gibum Kim, Hannwen Guan, Shuxin Cong
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Publication number: 20110085167Abstract: Instruments and methods relating to surface plasmon imaging are described. An instrument comprises a semi-circular rail and a driving mechanism. The driving mechanism is attached to a light source mount and a detector mount, and both the light source mount and the detector mount are attached to the semi-circular rail with connectors. Each connector allows the light source mount and detector mount to slide along the rail. The synchronous movement of the light source mount and the detector mount changes the angle of incidence of a light beam from the light source with respect to the plane of the sample surface on the sample stage.Type: ApplicationFiled: December 1, 2010Publication date: April 14, 2011Applicant: PLEXERA LLCInventors: HANN-WEN GUAN, SHUXIN CONG
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Patent number: 7889347Abstract: Instruments and methods relating to surface plasmon imaging are described. An instrument comprises a semi-circular rail and a driving mechanism. The driving mechanism is attached to a light source mount and a detector mount, and both the light source mount and the detector mount are attached to the semi-circular rail with connectors. Each connector allows the light source mount and detector mount to slide along the rail. The synchronous movement of the light source mount and the detector mount changes the angle of incidence of a light beam from the light source with respect to the plane of the sample surface on the sample stage.Type: GrantFiled: November 21, 2006Date of Patent: February 15, 2011Assignee: Plexera LLCInventors: Hann-Wen Guan, Shuxin Cong
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Patent number: 7745143Abstract: A method of analyzing a sample comprising directing a beam of light to a spot on the surface of a microarray treated with the sample using a digital micromirror device, and observing the SPR spectral shift due to a chemical binding event. The digital micromirror device can be, for example, that used in Digital Light Processing (DLP). Such a device can selectively place a pixel of light onto a microarray such that each spot can be observed at millisecond intervals and the whole microarray can be sequentially scanned over a relatively short period. The SPR spectral shift for each spot can be measured as a function of time, thus producing SPR detection of molecular binding in an array format.Type: GrantFiled: November 18, 2005Date of Patent: June 29, 2010Assignee: Plexera, LLCInventor: Vincenzo Casasanta, III
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Publication number: 20090262355Abstract: According to an embodiment, an SPR analysis system includes a housing enclosing with a fluid supply volume substantially enclosed within the housing, a flow cell module configured to receive reagents and analyte from the fluid supply volume, and an enclosed optics assembly configured to interrogate a microarray portion of the flow cell module.Type: ApplicationFiled: March 27, 2009Publication date: October 22, 2009Applicant: PLEXERA, LLCInventors: Paul Boeschoten, Christina Boozer, Pietro Brandani, Michael Cicirelli, Shuxin Cong, Larry Gill, Keith Hoffman, Gibum Kim, Timothy M. Londergan, Frank Metting, R. Todd Schwoerer, Christopher A. Wiklof, Yang Zhang
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Publication number: 20090262356Abstract: According to an embodiment, an SPR analysis system includes an SPR analysis system control computer program having a graphical user interface and configured to control the operation of an SPR analysis apparatus. According to an embodiment, an SPR data analysis computer program includes an SPR microarray video viewer and a sensorgram generator responsive to the SPR video.Type: ApplicationFiled: March 27, 2009Publication date: October 22, 2009Applicant: PLEXERA, LLCInventors: Paul Boeschoten, Christina Boozer, Pietro Brandani, John Cabrer, Michael Cicirelli, Shuxin Cong, Larry Gill, Keith Hoffman, Gibum Kim, Timothy M. Londergan, Frank Metting, R. Todd Schwoerer, Markus Tarin, Christopher A. Wiklof, Yang Zhang