Patents Assigned to Plexium, Inc.
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Patent number: 11911760Abstract: This disclosure provides for devices and methods for conduction assays for combinatorial libraries. The devices comprise a multiplicity of wells and a removable cap.Type: GrantFiled: June 21, 2021Date of Patent: February 27, 2024Assignee: Plexium, Inc.Inventors: Kapil Mahakalkar, Kenneth Chng, Jesse Lu, Edgar Gutierrez, Yi Zhang
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Patent number: 11878968Abstract: Disclosed are compounds and salts thereof that bind to and modulate cereblon activity. In some embodiments, the binding and modulation of cereblon results in the degradation of IKAROS family zinc finger proteins (e.g., IKZF2).Type: GrantFiled: November 3, 2022Date of Patent: January 23, 2024Assignee: Plexium, Inc.Inventors: Pengyu Yang, Simon Bailey
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Patent number: 11807620Abstract: Disclosed are substituted quinazolinone compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions to treat diseases, disorders, or conditions such as those relating to unregulated protein function and/or levels.Type: GrantFiled: February 19, 2021Date of Patent: November 7, 2023Assignee: Plexium, Inc.Inventors: Pengyu Yang, Mark Wilson, Mihai Azimioara
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Patent number: 11642675Abstract: A microfluidic system for fluid transport is provided. The microfluidic system includes a microfluidic device. The microfluidic device includes an inlet body including an inlet. The microfluidic device includes a base supporting the inlet body. The base includes a channel in fluid communication with the inlet. The base includes one or more sensors formed on a surface of the channel, or one or more sensors formed in one or more wells formed in the surface of the channel. The channel is configured to facilitate flow of the fluid. The fluid includes a plurality of beads. The fluid includes a plurality of suspended cells. The inlet is configured to receive the fluid at an inlet port. The inlet is configured to output the fluid through an opening in fluid communication with the channel. The inlet is configured to provide substantially uniform flow of the fluid across a substantial portion of a horizontal dimension of the channel. The device is configured to compensate for edge effects otherwise present therein.Type: GrantFiled: June 30, 2021Date of Patent: May 9, 2023Assignee: Plexium, Inc.Inventors: Edgar Gutierrez, Jesse Lu
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Patent number: 11577249Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.Type: GrantFiled: April 21, 2021Date of Patent: February 14, 2023Assignee: Plexium, Inc.Inventors: Kandaswamy Vijayan, Andrew Boyd MacConnell, Joseph Franklin Rokicki
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Patent number: 11305288Abstract: Disclosed is an assay device comprising a high density of wells aligned thereon.Type: GrantFiled: January 28, 2020Date of Patent: April 19, 2022Assignee: Plexium, Inc.Inventors: Yi Zhang, Jesse Lu, Alex Price, Pengyu Yang, Kandaswamy Vijayan
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Patent number: 11084037Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.Type: GrantFiled: September 24, 2018Date of Patent: August 10, 2021Assignee: Plexium, Inc.Inventors: Kandaswamy Vijayan, Andrew Boyd MacConnell, Joseph Franklin Rokicki
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Patent number: 11040343Abstract: This disclosure provides for devices and methods for conducting assays for combinatorial libraries. The devices comprise a multiplicity of wells and a removable cap.Type: GrantFiled: January 28, 2020Date of Patent: June 22, 2021Assignee: Plexium, Inc.Inventors: Kapil Mahakalkar, Kenneth Chung, Jesse Lu, Edgar Gutierrez, Yi Zhang
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Patent number: 11027272Abstract: Disclosed are transfer dispensers for assay devices. These dispensers provide for transfer of a single assay component into a single well in the assay device. This ensures that the assay conducted in each well contains only a single component.Type: GrantFiled: January 28, 2020Date of Patent: June 8, 2021Assignee: Plexium, Inc.Inventors: Kandaswamy Vijayan, Kapil Mahakalkar, Yi Zhang
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Patent number: 10981170Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.Type: GrantFiled: May 8, 2020Date of Patent: April 20, 2021Assignee: Plexium, Inc.Inventors: Kandaswamy Vijayan, Andrew Boyd MacConnell, Joseph Franklin Rokicki, Michael Van Nguyen
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Patent number: 10946383Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.Type: GrantFiled: August 7, 2019Date of Patent: March 16, 2021Assignee: Plexium, Inc.Inventors: Kandaswamy Vijayan, Andrew Boyd MacConnell, Joseph Franklin Rokicki
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Patent number: 10828643Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.Type: GrantFiled: August 7, 2019Date of Patent: November 10, 2020Assignee: Plexium, Inc.Inventors: Kandaswamy Vijayan, Andrew Boyd MacConnell, Joseph Franklin Rokicki
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Publication number: 20200324287Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.Type: ApplicationFiled: May 8, 2020Publication date: October 15, 2020Applicant: Plexium, Inc.Inventors: Kandaswamy VIJAYAN, Andrew Boyd MACCONNELL, Joseph Franklin ROKICKI, Michael VAN NGUYEN
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Publication number: 20200001295Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.Type: ApplicationFiled: August 7, 2019Publication date: January 2, 2020Applicant: Plexium, Inc.Inventors: Kandaswamy VIJAYAN, Andrew Boyd MACCONNELL, Joseph Franklin ROKICKI
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Publication number: 20190358629Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.Type: ApplicationFiled: August 7, 2019Publication date: November 28, 2019Applicant: Plexium, Inc.Inventors: Kandaswamy Vijayan, Andrew Boyd MacConnell, Joseph Franklin Rokicki
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Publication number: 20190210018Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.Type: ApplicationFiled: September 24, 2018Publication date: July 11, 2019Applicant: Plexium, Inc.Inventors: Kandaswamy VIJAYAN, Andrew Boyd MACCONNELL, Joseph Franklin Rokicki, Michael VAN NGUYEN
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Publication number: 20190093103Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.Type: ApplicationFiled: September 24, 2018Publication date: March 28, 2019Applicant: Plexium, Inc.Inventors: Kandaswamy VIJAYAN, Andrew Boyd MACCONNELL, Joseph Franklin Rokicki, Michael VAN NGUYEN