Patents Assigned to Plexxikon, Inc.
  • Synthesis of heterocyclic compounds
    Patent number: 11739088
    Abstract: Provided herein are intermediates and processes useful for facile synthesis of compounds of Formula 2: wherein R1 is C(O)R2; R2 is alkyl optionally substituted with 1-5 halogens; G is phenyl or a 5-6 membered heteroaryl optionally substituted with 1-2 R3; and each R3 is independently C1-C6 alkyl, CN, C1-C6 alkyl-CN, 3-6 membered cycloalkyl, or 4-6 membered heterocycloalkyl.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: August 29, 2023
    Assignee: PLEXXIKON INC.
    Inventors: Jack Lin, Jason Walters
  • Compounds and methods for kinase modulation, and indications therefor
    Patent number: 11337976
    Abstract: Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: May 24, 2022
    Assignee: Plexxikon Inc.
    Inventors: Prabha N. Ibrahim, Chao Zhang, Wayne Spevak, Jiazhong Zhang, Guoxian Wu, Jack Lin, Hanna Cho, Marika Nespi, Songyuan Shi, Todd Ewing, Ying Zhang
  • Compounds and methods for IDO and TDO modulation, and indications therefor
    Patent number: 11149011
    Abstract: Disclosed are compounds of Formula (I) and (Ia): or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein R4, R5, R6, and R7 are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: October 19, 2021
    Assignee: Plexxikon Inc.
    Inventors: Jiazhong Zhang, Hannah Powers, Aaron Albers, Phuongly Pham, Guoxian Wu, John Buell, Wayne Spevak, Zuojun Guo, Jack Walleshauser, Ying Zhang
  • Formulations of a compound modulating kinases
    Patent number: 11103505
    Abstract: Provided are solid dispersions of Compound I having the formula: wherein Compound I is substantially amorphous, methods of manufacturing said solid dispersions, and methods of using said solid dispersions.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: August 31, 2021
    Assignee: Plexxikon Inc.
    Inventors: Hamid Rezaei, Marika Nespi, Prabha N. Ibrahim, Gary Conard Visor
  • Formulations of a compound modulating kinases
    Patent number: 10961240
    Abstract: Provided are compositions comprising Compound I having the following structure: or a pharmaceutically acceptable salt thereof, and a solubilizing agent; methods of making the same; and methods of using the same.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: March 30, 2021
    Assignees: Plexxikon Inc., Daiichi Sankyo Company, Limited
    Inventors: Prabha N. Ibrahim, Hamid Rezaei, Gary Conard Visor, Tomoari Kamo, Hiroshi Yamakose
  • Formulations of a compound modulating kinases
    Patent number: 10941142
    Abstract: Provided are compositions comprising Compound I having the following structure: or a pharmaceutically acceptable salt thereof, and a solubilizing agent; methods of making the same; and methods of using the same.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: March 9, 2021
    Assignee: Plexxikon Inc.
    Inventors: Prabha N. Ibrahim, Hamid Rezaei, Gary Conard Visor, Tomoari Kamo, Hiroshi Yamakose
  • Heterocyclic compounds and uses thereof
    Patent number: 10899761
    Abstract: Provided herein are heterocyclic compounds of Formula (I), pharmaceutical compositions containing such a compound and their therapeutic uses, methods for their preparation, intermediate compounds, pharmaceutical compositions containing such a compound, and their therapeutic uses.
    Type: Grant
    Filed: April 2, 2020
    Date of Patent: January 26, 2021
    Assignee: Plexxikon Inc.
    Inventors: Prabha N. Ibrahim, Wayne Spevak, Jiazhong Zhang, Songyuan Shi, Ben Powell, Yan Ma
  • Compounds and methods for kinase modulation, and indications therefor
    Patent number: 10829484
    Abstract: Compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein A, J, R1, R2, R3, R4, R5, R6, R7, R9, X, m and n are as described herein, compositions thereof, and methods and uses thereof.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: November 10, 2020
    Assignee: Plexxikon Inc.
    Inventors: Mark W. Holladay, Gang Liu
  • Synthesis of a compound that modulates kinases
    Patent number: 10730876
    Abstract: The present disclosure provides processes for the preparation of a compound of formula I: or a salt thereof, active on the receptor protein kinases c-Kit and/or c-Fms and/or Flt3. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: August 4, 2020
    Assignees: Plexxikon Inc., Daiichi Sankyo Company, Limited
    Inventors: Prabha N. Ibrahim, Masayoshi Jin, Shinji Matsuura
  • Solid forms of a compound for modulating kinases
    Patent number: 10717735
    Abstract: Forms of 4-(6-(3,5-dimethylisoxazol-4-yl)-1-[(1S)-1-(2-pyridyl)ethyl]pyrrolo[3,2-b]pyridin-3-yl)benzoic acid (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the forms of Compound I.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: July 21, 2020
    Assignee: Plexxikon Inc.
    Inventors: Prabha N. Ibrahim, Hamid Rezaei, Marika Nespi, Ben Powell, Rashmin Patel
  • Compounds and methods for CDK8 modulation and indications therefor
    Patent number: 10703757
    Abstract: Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein R4, X3, X4, X5, X6, X7 and Ring A are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: July 7, 2020
    Assignee: Plexxikon Inc.
    Inventors: Guoxian Wu, Aaron Albers, John Buell, Elizabeth A. Burton, Phuongly Pham, Hannah Powers, Songyuan Shi, Wayne Spevak, Jeffrey Wu, Jiazhong Zhang
  • Heterocyclic compounds and uses thereof
    Patent number: 10647716
    Abstract: Provided herein are heterocyclic compounds of Formula (I), pharmaceutical compositions containing such a compound and their therapeutic uses, methods for their preparation, intermediate compounds, pharmaceutical compositions containing such a compound, and their therapeutic uses.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: May 12, 2020
    Assignee: Plexxikon Inc.
    Inventors: Prabha N. Ibrahim, Wayne Spevak, Jiazhong Zhang, Songyuan Shi, Ben Powell, Yan Ma
  • Solid forms of a compound modulating kinases
    Patent number: 10584122
    Abstract: Solid forms of the compound, [5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-pyridin-2-yl]-(6-trifluoromethyl-pyridin-3-ylmethyl)-amine HCl salt (Compound I) and its free base, active on the receptor protein kinases c-Kit and/or c-Fms and/or Flt3, were prepared and characterized: Also provided are methods of using the solid forms.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: March 10, 2020
    Assignee: Plexxikon Inc.
    Inventors: Prabha N. Ibrahim, Gary Conard Visor
  • Crystalline forms of a compound that inhibits bromodomain
    Patent number: 10577366
    Abstract: Forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1H-pyrrolo[3,2-b]pyridin-3-yl)benzoic acid were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the forms of Compound I.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: March 3, 2020
    Assignee: Plexxikon Inc.
    Inventors: Jack Lin, Marika Nespi, Jason Walters
  • Heterocyclic compounds and uses thereof
    Patent number: 10519177
    Abstract: Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: December 31, 2019
    Assignee: Plexxikon Inc.
    Inventors: Jiazhong Zhang, John Buell, Katrina Chan, Prabha N. Ibrahim, Jack Lin, Phuongly Pham, Songyuan Shi, Wayne Spevak, Guoxian Wu, Jeffrey Wu
  • Compounds and methods for IDO and TDO modulation, and indications therefor
    Patent number: 10508085
    Abstract: Disclosed are compounds of Formula I(a): or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein R4, R5, R6, R7, G1, G2 and Ring A are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: December 17, 2019
    Assignee: Plexxikon Inc.
    Inventors: Jiazhong Zhang, Hannah Powers, Aaron Albers, Phuongly Pham, Guoxian Wu, John Buell, Wayne Spevak, Zuojun Guo, Jack Walleshauser, Ying Zhang
  • Heterocyclic compounds and uses thereof
    Patent number: 10501460
    Abstract: Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: December 10, 2019
    Assignee: Plexxikon Inc.
    Inventors: Jiazhong Zhang, Wayne Spevak
  • Formulations of a compound modulating kinases
    Patent number: 10435404
    Abstract: Provided are compositions comprising Compound I having the following structure: or a pharmaceutically acceptable salt thereof, and a solubilizing agent; methods of making the same; and methods of using the same.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: October 8, 2019
    Assignees: Plexxikon Inc., Daiichi Sankyo Company, Limited
    Inventors: Prabha N. Ibrahim, Hamid Rezaei, Gary Conard Visor, Tomoari Kamo, Hiroshi Yamakose
  • Compounds and methods for kinase modulation
    Patent number: 10428067
    Abstract: Disclosed are compounds having a compound of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, compositions thereof, and uses thereof.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: October 1, 2019
    Assignee: Plexxikon Inc.
    Inventors: Chao Zhang, Guoxian Wu, Wayne Spevak, Zuojun Guo, Ying Zhang
  • Compounds and methods for kinase modulation, and indications therefor
    Patent number: 10426760
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: October 1, 2019
    Assignee: Plexxikon Inc.
    Inventors: Guoxian Wu, Jiazhong Zhang, Yong-Liang Zhu, Chao Zhang, Prabha N. Ibrahim, Songyuan Shi, Wayne Spevak, Dean R. Artis, James Tsai