Patents Assigned to Pliva Handels GmbH
  • Amides of 4-oxo-azetidine-2-sulfonic acids and salts thereof, processes for their preparation and their use
    Patent number: 5466686
    Abstract: The invention relates to the novel 4-oxo-azetidine-2-sulfonic acid amides and their salts of the formula I ##STR1## wherein the radicals have the meanings: R.sup.1 =hydrogen, halogen;R.sup.2 =hydrogen, halogen, NH.sub.2, C.sub.6 H.sub.5 CH.sub.2 CONH, C.sub.6 H.sub.5 OCH.sub.2 CONH, phthalimido, o-MeNHCOC.sub.6 H.sub.4 CONH, isoxazolylcarbonylamino;R.sup.3 =hydrogen, Me.sub.2 C.dbd.C--COOMe, H.sub.2 C.dbd.C(Me)--CH--COOMe, Me.sub.2 C.dbd.C--COOCH.sub.2 C.sub.6 H.sub.5, H.sub.2 C.dbd.C(Me)CH--COOCH.sub.2 C.sub.6 H.sub.4 NO.sub.2 -p, Me.sub.2 C.dbd.C--COOCH.sub.2 C.sub.6 H.sub.4 NO.sub.2 -p, Me.sub.2 C.dbd.C--COOCH.sub.2 C.sub.6 H.sub.4 Me-m, H.sub.2 C.dbd.C(Me)--CH--COOCH.sub.2 C.sub.6 H.sub.4 Me-m, Me.sub.2 C.dbd.C--COOH;R.sup.4 =hydrogen or sodium andR.sup.5 =hydrogen, alkyl, benzyl or heterocycle, i.e. isoxazole or pyrazole etc.
    Type: Grant
    Filed: September 3, 1993
    Date of Patent: November 14, 1995
    Assignee: PLIVA and PLIVA Handels GmbH
    Inventors: Mice Kovacevic, Jure J. Herak, Zora Mandic, Irena Lukic, Mirjana Tomic, Zinka Brkic
  • N-sulfonyl-tetrahydro-[1,3]-dioxepino[5,6-biazirines, intermediates for their preparation and their use
    Patent number: 5286744
    Abstract: Starting from cis-2-butene-1,4-diol, via the 4,7-dihydro-1,3-dioxepin and trans-6-acylamino-5-chloro-1,3-dioxepans the novel tetrahydro-[1,3]-dioxepino[5,6-b]-azirines were synthesized, and therefrom the novel hypoglycaemically active N-sulfonyl-tetrahydro-[1,3]-dioxepino[5,6-b]azirines. The inventive compounds are valuable intermediates in the synthesis of other, biologically active substances.
    Type: Grant
    Filed: August 20, 1992
    Date of Patent: February 15, 1994
    Assignees: Pliva Handels GmbH, Pliva
    Inventors: Miljenko Dumic, Darko Filic, Mladen Vinkovi, Blanka Jamnicky
  • 4-oxo-azetidine-2-sulfonic acids and their salts, processes for the preparation thereof and their use
    Patent number: 5250525
    Abstract: The invention relates to novel 4-oxo-azetidine-2-sulfonic acids and their salts or the formula I ##STR1## wherein: R.sup.1 =hydrogen, halogen, phenylacetamido;R.sup.2 =hydrogen, halogen, phenylacetamido, phenoxyacetamido, phthalimido, 5-methyl-3-o-chlorophenyl-isoxazole-4-carboxamido;R.sup.3 =hydrogen, alkali metal, alkaline earth metal, quaternary ammonium group;R.sup.4 =hydrogen, SO.sub.2 O.sup.-+ NBu.sub.4 -n, (CH.sub.3).sub.2 C.dbd.C--COOCH.sub.3, (CH.sub.3).sub.2 C.dbd.C--COOCH.sub.2 -Ph, (CH.sub.3).sub.2 C.dbd.C--COOCH.sub.2 --C.sub.6 H.sub.4 --NO.sub.2 -p, (CH.sub.3).sub.2 C.dbd.C--COOCH.sub.2 --C.sub.6 H.sub.4 --CH.sub.3 -m.The products (I) may be used as intermediates in the synthesis of beta-lactamic antibiotics or as components in antimicrobial preparations.
    Type: Grant
    Filed: February 11, 1992
    Date of Patent: October 5, 1993
    Assignee: Pliva Handels GmbH
    Inventors: Mice Kovacevic, Zorica Mandic, Mirjana Tomic, Zinka Brkic, Jure J. Herak, Irena Lukic