Patents Assigned to PLIVA-ISTRAZIVACKI INSTITUT D.D.D.
  • 1-or 3-thia-benznaphthoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
    Publication number: 20050137249
    Abstract: The present invention relates to 1- or 3-thiabenzonaphthoazulene derivafives to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-alpha (TNF-alpha) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
    Type: Application
    Filed: April 9, 2003
    Publication date: June 23, 2005
    Applicant: PLIVA-ISTRAZIVACKI INSTITUT D.D.D.
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Ivana Ozimec, Rudolf Trojko