Patents Assigned to Pluristem Ltd.
  • METHODS AND COMPOSITIONS FOR TREATING VIRAL INFECTIONS AND SEQUELAE THEREOF
    Publication number: 20230338432
    Abstract: Disclosed herein are methods and compositions comprising placental adherent stromal cells for treating viral infections and sequelae thereof.
    Type: Application
    Filed: March 11, 2021
    Publication date: October 26, 2023
    Applicant: PLURISTEM LTD.
    Inventors: Yaacob YANAY, Rachel OFIR, Marc TRITEL
  • Methods And Compositions For Aesthetic And Cosmetic Treatment And Stimulating Hair Growth
    Publication number: 20220202875
    Abstract: Disclosed herein are methods and compositions comprising placental adherent stromal cells, conditioned media derived from a cultured placental ASC, lysates thereof, and fractions thereof, for treating a skin condition (e.g. a compromised skin barrier, acne, wrinkles, hyper/hypo-pigmentation, dryness, elastosis); increasing skin volume, and preventing or treating alopecia and related conditions.
    Type: Application
    Filed: March 14, 2022
    Publication date: June 30, 2022
    Applicant: PLURISTEM LTD.
    Inventors: Yaacob YANAY, Lior RAVIV, Murielle AGASSI, Sagi MORAN
  • USE OF ADHERENT STROMAL CELLS FOR ENHANCING HEMATOPOIESIS IN A SUBJECT IN NEED THEREOF
    Publication number: 20220184140
    Abstract: Disclosed herein are methods and compositions comprising adherent stromal cells.
    Type: Application
    Filed: March 7, 2022
    Publication date: June 16, 2022
    Applicant: PLURISTEM LTD.
    Inventor: Zami ABERMAN
  • Methods and Compositions for Producing Cannabinoids
    Publication number: 20220046883
    Abstract: Disclosed herein are methods of producing one or more cannabinoid compounds, expanding cells that produce the compounds, cannabinoid compounds produced by the methods, pharmaceutical compositions comprising the cannabinoid compounds, and methods of producing and utilizing the compounds and compositions.
    Type: Application
    Filed: April 20, 2020
    Publication date: February 17, 2022
    Applicant: PLURISTEM LTD.
    Inventors: Yaacob YANAY, Lior RAVIV
  • Modular Bioreactor
    Publication number: 20220033751
    Abstract: The present disclosure relates to use of systems for culturing, incubating, and/or expanding adherent cells.
    Type: Application
    Filed: October 3, 2019
    Publication date: February 3, 2022
    Applicant: PLURISTEM LTD.
    Inventors: Lior RAVIV, Nadav ESHKOL, Dorina ROBERMAN
  • METHODS AND COMPOSITIONS FOR TREATING SUBJECTS EXPOSED TO VESICANTS AND OTHER CHEMICAL AGENTS
    Publication number: 20210353687
    Abstract: Disclosed herein are methods and compositions comprising adherent stromal cells.
    Type: Application
    Filed: June 18, 2019
    Publication date: November 18, 2021
    Applicant: PLURISTEM LTD.
    Inventors: Arie EISENKRAFT, Yaacob YANAY, Rachel OFIR
  • THERAPEUTIC METHODS AND COMPOSITIONS
    Publication number: 20210338740
    Abstract: Disclosed herein are pharmaceutical compositions and methods comprising or utilizing placental adherent stromal cells. The pharmaceutical compositions may be indicated for ameliorating or treating various disorders, e.g., impaired glucose tolerance. Alternatively, the pharmaceutical composition may be indicated for ameliorating or treating systemic inflammation, e.g., in a subject with impaired glucose tolerance. The pharmaceutical compositions may further include pharmacologically acceptable excipients.
    Type: Application
    Filed: November 6, 2019
    Publication date: November 4, 2021
    Applicant: PLURISTEM LTD.
    Inventors: Zami ABERMAN, Yaacob YANAY, Rachel OFIR, Marc TRITEL, Hoshea Yissachar ALLEN, Niva SHRAGA HELED
  • METHODS AND COMPOSITIONS FOR TREATING VIRAL INFECTIONS
    Publication number: 20210283189
    Abstract: Disclosed herein are methods and compositions comprising placental adherent stromal cells for treating viral infections and sequelae thereof.
    Type: Application
    Filed: March 11, 2021
    Publication date: September 16, 2021
    Applicant: PLURISTEM LTD.
    Inventors: Yaacob Yanay, Rachel Ofir, Marc Tritel
  • THERAPEUTIC DOSAGE REGIMENS COMPRISING ADHERENT STROMAL CELLS
    Publication number: 20210228635
    Abstract: Disclosed herein are pharmaceutical compositions and therapeutic dosage regimens comprising or utilizing adherent stromal cells. The adherent stromal cells may be derived e.g. from placental tissue, from adipose tissue, or from bone marrow. The pharmaceutical compositions may be indicated for treating various disorders, e.g. ischemic disorders, hematopoietic disorders, and neurodegenerative disorders, inflammatory disorders, and neoplasms. The pharmaceutical compositions may further include pharmacologically acceptable excipients.
    Type: Application
    Filed: June 10, 2019
    Publication date: July 29, 2021
    Applicant: PLURISTEM LTD.
    Inventors: Zami ABERMAN, Yaacob YANAY, Rachel OFIR, Marc TRITEL
  • METHODS AND COMPOSITIONS FOR FORMULATING AND DISPENSING PHARMACEUTICAL FORMULATIONS
    Publication number: 20210139834
    Abstract: The present disclosure relates to use of specialized vessels for formulating and dispensing pharmaceutical formulations. The vessels are optionally able to maintain homeostatic conditions and a homogeneous constitution of pharmaceutical suspensions, while simultaneously dispensing them into single-use containers.
    Type: Application
    Filed: April 16, 2019
    Publication date: May 13, 2021
    Applicant: PLURISTEM LTD.
    Inventors: Lior RAVIV, Nadav ESHKOL, Dorina ROBERMAN
  • METHODS FOR EXPANDING ADHERENT STROMAL CELLS AND CELLS OBTAINED THEREBY
    Publication number: 20210115395
    Abstract: Disclosed herein are methods of expanding adherent stromal cells, including, inter alia, multi-step methods. Also disclosed are cells produced by the methods, which may be adherent stromal cells, for example placental adherent stromal cells. Further disclosed are pharmaceutical compositions comprising the cells. Additionally, methods of producing and utilizing the compositions, for example for therapeutic uses, are described.
    Type: Application
    Filed: March 28, 2019
    Publication date: April 22, 2021
    Applicant: PLURISTEM LTD.
    Inventors: Lior RAVIV, David WILDAWER, Eva Bjerge ZINO
  • Methods and systems for harvesting cells
    Patent number: 10851341
    Abstract: Methods for using vibration to harvest cells grown in 3D culture are provided. The methods entail the application of force cells attached to a 3D matrix of sufficient amplitude, frequency, and duration to detach cells from the matrix and to flush the detached cells out of the matrix material. An apparatus for performing the methods of the invention as provided.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: December 1, 2020
    Assignee: Pluristem Ltd.
    Inventors: Harel Kasuto, Nirit Drori-carmi, Barak Zohar
  • Altered adherent stromal cells and methods of producing and using same
    Patent number: 10851347
    Abstract: Disclosed herein are altered adherent stromal cells and methods of producing and utilizing same.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: December 1, 2020
    Assignee: PLURISTEM LTD.
    Inventors: Eytan Abraham, Lior Raviv, Maya Wadamany, Nadav Eshkol
  • METHODS FOR TREATING RADIATION OR CHEMICAL INJURY
    Publication number: 20200306319
    Abstract: Methods for treating radiation or chemical injury are described that comprise administering to a subject a therapeutically effective amount of adherent stromal cells. Methods of preparing adherent stromal cells and pharmaceutical compositions comprising the cells are also described.
    Type: Application
    Filed: June 9, 2020
    Publication date: October 1, 2020
    Applicant: PLURISTEM LTD.
    Inventors: Raphael GORODETSKY, Zami ABERMAN
  • ADHERENT CELLS FROM PLACENTA AND USE OF SAME IN DISEASE TREATMENT
    Publication number: 20200306318
    Abstract: Methods for treating conditions by administration of placenta derived adherent stromal cells to a subject in thereof are provided. Such conditions include skeletal muscle defects, neuropathic pain, and myocardial infarction. Also provided are methods wherein the adherent stromal cells administered are cultured under 2 dimensional or 3 dimensional growth conditions. Also provided are methods in which the cells administered are at least 70% adherent cells from a maternal or fetal portion of the placenta.
    Type: Application
    Filed: January 22, 2020
    Publication date: October 1, 2020
    Applicant: PLURISTEM LTD.
    Inventor: ABERMAN Zami
  • METHODS AND COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS
    Publication number: 20200246386
    Abstract: Disclosed herein are methods and compositions for cell induction and treating neurological disorders, utilizing adherent stromal cells, which may, for example, be derived from placental tissue, bone marrow, or adipose tissue. Also provided are pharmaceutical compositions comprising the described cells, optionally in combination with pharmaceutically acceptable excipients.
    Type: Application
    Filed: April 23, 2018
    Publication date: August 6, 2020
    Applicant: PLURISTEM LTD.
    Inventors: Rachel OFIR, Niva SHRAGA HELED
  • Methods for treating radiation or chemical injury
    Patent number: 10722541
    Abstract: Methods for treating radiation or chemical injury are described that comprise administering to a subject a therapeutically effective amount of adherent stromal cells. Methods of preparing adherent stromal cells and pharmaceutical compositions comprising the cells are also described.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: July 28, 2020
    Assignee: PLURISTEM LTD.
    Inventors: Zami Aberman, Raphael Gorodetsky
  • METHODS AND COMPOSITIONS FOR TREATING ADDICTIONS
    Publication number: 20200155611
    Abstract: Disclosed herein are methods and compositions comprising adherent stromal cells.
    Type: Application
    Filed: July 23, 2018
    Publication date: May 21, 2020
    Applicants: PLURISTEM LTD., BAR ILAN UNIVERSITY
    Inventors: Gal YADID, Rachel OFIR, Niva SHRAGA HELED
  • ALTERED ADHERENT STROMAL CELLS AND METHODS OF PRODUCING AND USING SAME
    Publication number: 20200131481
    Abstract: Disclosed herein are altered adherent stromal cells and methods of producing and utilizing same.
    Type: Application
    Filed: June 6, 2016
    Publication date: April 30, 2020
    Applicant: PLURISTEM LTD.
    Inventors: Eytan ABRAHAM, Lior RAVIV, Maya WADAMANY, Nadav ESHKOL
  • Adherent cells from placenta and use of same in disease treatment
    Patent number: 10610545
    Abstract: Methods for treating conditions by administration of placenta derived adherent stromal cells to a subject in thereof are provided. Such conditions include skeletal muscle defects, neuropathic pain, and myocardial infarction. Also provided are methods wherein the adherent stromal cells administered are cultured under 2 dimensional or 3 dimensional growth conditions. Also provided are methods in which the cells administered are at least 70% adherent cells from a maternal or fetal portion of the placenta.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: April 7, 2020
    Assignee: PLURISTEM LTD.
    Inventor: Zami Aberman