Abstract: The present invention relates to a process for preparing simvastatin, wherein the simvastatin dimer content is controlled. More particularly, the present invention relates to a process for preparing simvastatin having a simvastatin dimer content of about 0.2 to about 0.4% wt. The present invention also relates to a process for preparing simvastatin having a simvastatin dimer content of less than about 0.2% wt. The present invention also discloses a commercial scale process of preparing simvastatin having a specified simvastatin dimer content which is reproducible.
Type:
Grant
Filed:
February 11, 2004
Date of Patent:
February 7, 2006
Assignee:
Plus Chemicals, B.V.
Inventors:
Ferenc Korodi, Csaba Szabo, Szabolcs Salyi, Istvan Bodi
Abstract: The present invention relates to a process to prepare semi synthetic statins, to intermediates formed during said process and to highly purified simvastatin produced by the process.
Type:
Grant
Filed:
July 26, 2001
Date of Patent:
February 3, 2004
Assignee:
Plus Chemicals, B.V.
Inventors:
Szabo Csaba, Ferenc Korodi, Melczer Istvan, Szabolcs Salyi, David Leonov
Abstract: A process has been provided to produce semi synthetic statins, as for instance simvastatin with a high yield, for another statin, preferably a naturally occurring statin, as for instance lovastatin. Also a number of novel intermediate compounds, prepared during said process, has been provided.
Type:
Grant
Filed:
January 5, 2000
Date of Patent:
September 25, 2001
Assignee:
Plus Chemicals, B.V.
Inventors:
Ton Rene Vries, Hans Wijnberg, Wijnand Sjourd Faber, Venetka Ivanova Kalkman-Agayn, Mieke Ivanova Sibeyn
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