Abstract: Disclosed herein are novel drug carriers including a non-aqueous pH dependent release system and a non-aqueous pH dependent reassembly/assembly and reabsorption/absorption system. The carriers are capable of pH dependent release of biologically active agents and assembly or reassembly when the carrier transitions from a low pH environment, to a high pH environment and back to a low pH environment.
Type:
Grant
Filed:
July 16, 2021
Date of Patent:
May 16, 2023
Assignee:
PLx Opco Inc.
Inventors:
Ronald R. Zimmerman, Efthymios Deliargyris, Robert W. Strozier, Jeffrey W. Moore
Abstract: Disclosed herein are novel drug carriers including a non-aqueous pH dependent release system and a non-aqueous pH dependent reassembly/assembly and reabsorption/absorption system. The carriers are capable of pH dependent release of biologically active agents and assembly or reassembly when the carrier transitions from a low pH environment, to a high pH environment and back to a low pH environment.
Type:
Application
Filed:
February 18, 2022
Publication date:
June 2, 2022
Applicant:
PLx Opco Inc.
Inventors:
Ronald R. ZIMMERMAN, Efthymios DELIARGYRIS, Robert W. STROZIER, Jeffrey W. MOORE
Abstract: Disclosed herein are novel drug carriers including a non-aqueous pH dependent release system and a non-aqueous pH dependent reassembly/assembly and reabsorption/absorption system. The carriers are capable of pH dependent release of biologically active agents and assembly or reassembly when the carrier transitions from a low pH environment, to a high pH environment and back to a low pH environment.
Type:
Application
Filed:
July 16, 2021
Publication date:
January 6, 2022
Applicant:
PLx Opco Inc.
Inventors:
Ronald R. ZIMMERMAN, Efthymios DELIARGYRIS, Robert W. STROZIER, Jeffrey W. MOORE
Abstract: Novel drug carriers capable of targeted and/or pH dependent release of biologically active agents into selected pH environments including the gastrointestinal (GI), ophthalmic, urinary, or reproductive tracts. Unexpectedly, carriers including free fatty acids (FFA) are able to deliver biologically active agents to various pH environments. Such targeted delivery is tailorable and useful for active agents that are: (a) injurious to the upper GI tract (esophagus, stomach, and duodenum), (b) acid labile, (c) impermeable/insoluble compounds in GI fluids, (d) susceptible to first pass metabolism, and/or (e) cause stomach irritation, upset, or dyspepsia.
Type:
Grant
Filed:
March 27, 2020
Date of Patent:
September 29, 2020
Assignee:
PLx Opco Inc.
Inventors:
Upendra Marathi, Susann Childress, Shaun Gammill, Robert W. Strozier
Abstract: Novel drug carriers capable of targeted and/or pH dependent release of biologically active agents into selected pH environments including the gastrointestinal (GI), ophthalmic, urinary, or reproductive tracts. Unexpectedly, carriers including free fatty acids (FFA) are able to deliver biologically active agents to various pH environments. Such targeted delivery is tailorable and useful for active agents that are: (a) injurious to the upper GI tract (esophagus, stomach, and duodenum), (b) acid labile, (c) impermeable/insoluble compounds in GI fluids, (d) susceptible to first pass metabolism, and/or (e) cause stomach irritation, upset, or dyspepsia.
Type:
Application
Filed:
March 27, 2020
Publication date:
July 16, 2020
Applicant:
PLx Opco Inc.
Inventors:
Upendra Marathi, Susann Childress, Shaun Gammill, Robert W. Strozier
Abstract: Novel drug carriers capable of targeted and/or pH dependent release of biologically active agents into selected pH environments including the gastrointestinal (GI), ophthalmic, urinary, or reproductive tracts. Unexpectedly, carriers including free fatty acids (FFA) are able to deliver biologically active agents to various pH environments. Such targeted delivery is tailorable and useful for active agents that are: (a) injurious to the upper GI tract (esophagus, stomach, and duodenum), (b) acid labile, (c) impermeable/soluble compounds in GI fluids, (d) susceptible to first pass metabolism, and/or (e) cause stomach irritation, upset, or dyspepsia.
Type:
Grant
Filed:
November 7, 2018
Date of Patent:
May 12, 2020
Assignee:
PLx Opco Inc.
Inventors:
Upendra K. Marathi, Susann Edler Childress, Shaun L. Gammill, Robert W. Strozier
Abstract: Novel drug carriers capable of targeted and/or pH dependent release of biologically active agents into selected pH environments including the gastrointestinal (GI), ophthalmic, urinary, or reproductive tracts. Unexpectedly, carriers including free fatty acids (FFA) are able to deliver biologically active agents to various pH environments. Such targeted delivery is tailorable and useful for active agents that are: (a) injurious to the upper GI tract (esophagus, stomach, and duodenum), (b) acid labile, (c) impermeable/soluble compounds in GI fluids, (d) susceptible to first pass metabolism, and/or (e) cause stomach irritation, upset, or dyspepsia.
Type:
Application
Filed:
November 7, 2018
Publication date:
March 7, 2019
Applicant:
PLx Opco Inc.
Inventors:
Upendra K. Marathi, Susann Edler Childress, Shaun L. Gammill, Robert W. Strozier
Abstract: Novel drug carriers capable of targeted and/or pH dependent release of biologically active agents into selected pH environments including the gastrointestinal (GI), ophthalmic, urinary, or reproductive tracts. Unexpectedly, carriers including free fatty acids (FFA) are able to deliver biologically active agents to various pH environments. Such targeted delivery is tailorable and useful for active agents that are: (a) injurious to the upper GI tract (esophagus, stomach, and duodenum), (b) acid labile, (c) impermeable/insoluble compounds in GI fluids, (d) susceptible to first pass metabolism, and/or (e) cause stomach irritation, upset, or dyspepsia.
Type:
Grant
Filed:
July 7, 2017
Date of Patent:
January 15, 2019
Assignee:
PLX OPCO INC.
Inventors:
Upendra K. Marathi, Susann Edler Childress, Shaun L. Gammill, Robert W. Strozier
Abstract: Novel drug carriers capable of targeted and/or pH dependent release of biologically active agents into selected pH environments including the gastrointestinal (GI), ophthalmic, urinary, or reproductive tracts. Unexpectedly, carriers including free fatty acids (FFA) are able to deliver biologically active agents to various pH environments. Such targeted delivery is tailorable and useful for active agents that are: (a) injurious to the upper GI tract (esophagus, stomach, and duodenum), (b) acid labile, (c) impermeable/insoluble compounds in GI fluids, (d) susceptible to first pass metabolism, and/or (e) cause stomach irritation, upset, or dyspepsia.
Type:
Application
Filed:
July 7, 2017
Publication date:
October 26, 2017
Applicant:
PLx Opco Inc.
Inventors:
Upendra K. MARATHI, Susann Edler CHILDRESS, Shaun L. GAMMILL, Robert W. STROZIER
Abstract: Novel drug carriers capable of targeted and/or pH dependent release of biologically active agents into selected pH environments including the gastrointestinal (GI), ophthalmic, urinary, or reproductive tracts. Unexpectedly, carriers including free fatty acids (FFA) are able to deliver biologically active agents to various pH environments. Such targeted delivery is tailorable and useful for active agents that are: (a) injurious to the upper GI tract (esophagus, stomach, and duodenum), (b) acid labile, (c) impermeable/insoluble compounds in GI fluids, (d) susceptible to first pass metabolism, and/or (e) cause stomach irritation, upset, or dyspepsia.
Type:
Grant
Filed:
September 29, 2012
Date of Patent:
August 15, 2017
Assignee:
PLx Opco Inc.
Inventors:
Upendra K. Marathi, Susann Edler Childress, Shaun L. Gammill, Robert W. Strozier