Abstract: The present application concerns a microfluidic cassette for synthesizing a radiotracer including a microfluidic circuit in a support card that includes at least one intake for supply by a vial, at least one isotope port, at least one reaction chamber, at least one mixing chamber, at least one formulation chamber, and at least one connection for a syringe, linked together by capillaries. Also disclosed is a method for synthesizing a radiotracer in such a cassette.

Abstract: Disclosed is a gas targeting system including a body, which has a frustoconical cavity; a cooling circuit including at least one channel which surrounds at least one portion of the cavity; a window, positioned facing an inlet of the cavity in order to close the cavity, including a fine sheet that is permeable to at least a portion of a beam of particles emitted by a particle accelerator and a support grid configured to support pressure differences between and inside of the cavity and an outside of the targeting system, with the fine sheet positioned between the support grid and the cavity; and a support flange which holds the window and is hermetically secured on the body, and which includes a mechanical attachment interface at the outlet of a particle accelerator.

Abstract: Disclosed is a system for irradiating a target. The system includes a particle accelerator configured to at least emit an irradiation beam along an axis, a target-holder mounting outside the accelerator, a radiation-protection enclosure surrounding the target-holder mounting, and a deflection device. The particle accelerator is positioned outside the enclosure. The target-holder mounting includes at least one port configured to receive a target holder for a target to be irradiated. The target-holder mounting is stationary relative to the particle accelerator. The port is offset relative to the axis of the irradiation beam. The deflection device is positioned in the radiation-protection enclosure and is configured to divert the irradiation beam towards the port of the target holder in which the target to be irradiated is inserted.

Abstract: An irradiation device using ionizing radiation, particularly for radiation therapy and/or radiation biology, simultaneously includes: at least one unit (MER) for emitting ionizing radiation; at least one dose-monitoring unit (MCD); at least one unit for detecting an ionizing radiation dose (MDD); and at least one monitoring and control system (SCC). The units (MER, MDD, MCD) and the system (SCC) are also intelligently interconnected therebetween so as to engage with one another and form an intelligent monitoring and adjustment loop, such as to controllably, precisely and desirably produce strong doses of ionizing radiation of at least 0.01 Gy, having a precision within at least one 1? Gy but preferably 1 n Gy, in strong dose rates up to 1000 Gy/s with power within a range of 1 to 50 Me V in very brief time intervals of at least 0.1 ?s, preferably 1 ms.

Abstract: A system (100) for controlling the environment in a reaction box (300) comprises a controller (150) configured to control a gas multiplexer (130) to switch between applying an under pressure in the reaction box (300) from a vacuum pump (140) and applying a gas flow from a connected gas source (200) to the reaction box (300) multiple times in a cyclic manner. A particle monitor (160) generates particle information representing a concentration of particles in the reaction box (300). This particle information is stored as a GMP clean room classification notification for the reaction box (300).

Abstract: A device for detacking leaf material (T), such as tobacco leaf, from bobbin (B), provided with a frame (1), a table (2) with co-acting detacking member connected to the frame, a winding-off reel (3) for the filled belt-shaped carrier, a winding-up reel (20) for the emptied belt-shaped carrier connected to the frame and guide rollers (17, 18, 19) such that the belt is guided stretched over the table, wherein a straight guide edge (8) is placed at a short distance to the front edge (26) of the table in order to form a gap-like space, the winding-off reel is held in or close to a plane which extends perpendicularly of the table and through the guide edge, and one of the guide rollers (17) is arranged on the side of the guide edge remote from the winding-off reel, so that the belt is bent sharply, the tobacco leaf is drawn loose of the belt part and still deposited on the same side of the belt part, whereby any adhesion that may occur is eliminated.

Abstract: A method and a device for dividing a whole or half a tobacco leaf into usable portions, for example, binders or wrappers, in which the tobacco leaf is spread on two or more contour knives, the cutting edges of which are pressed across the material of the tobacco leaf, wherein the punched-out tobacco leaf portions are lifted out of the contour knives, and deposited on a carrier by means of a suction box conveyor; the leaf portions are subsequently scanned by a scanning apparatus having an electronic processing and control circuitry, controlling pick-up means to pick-up the approved leaf portions from said carrier and to carry them into a bobbin.

Abstract: A device for storing tobacco leaves or parts thereof in a winding belt or a bobbin, mainly comprising a frame having at least one deposition table formed like a suction box (1) having separate sections and a run-on and a run-off rim, a reel (4) for the winding belt adapted to reciprocate with respect to the run-off rim of the table and a rotatable driving element formed like a roller and associated with each table and having its rotary axis arranged parallel to that of the reel freely rotatable in the frame, which roller presses against the bobbin circumference and is adapted to advance the belt across the table and to wind it on the reel whereas the tightening force experienced by the tape during the winding operation is determined by belt-engaging braking means (11, 19) in front of the run-on rim of the table.

Abstract: A cutting die assembly for cigar wrappers is manufactured by rigidly interconnecting a knife blade unit and a die assembly on a common carrier. The die assembly has an opening of particular shape bounded by a generally planar margin over which tobacco leaf may be draped. The knife unit is formed by shaping knife blade strip into a closed form to fit just inside the shaped margin of the die assembly with the knife edge just above same. The shaped knife blade strip is filled with a filling body interiorally to a height substantially below the cutting edge and is internally rigidified thereby. A suction air chamber is defined by the rigidly interconnected units and is bounded by the common carrier, the die assembly and the outer surface of the knife blade strip. Openings are provided through the margin of the die assembly to the suction air chamber to hold the draped tobacco leaf and stretch it over the knife edge.

Abstract: A method and a device for the manufacture of cigars in which each bunch or filler is enveloped in a tobacco leaf portion, wherein the bunches or fillers are advanced one after the other along a given length, whilst a tobacco leaf portion is applied along at least part of said length of path in a stretched form to each advancing filler and wrapped around the same, due to the fact that the bunches or fillers are not stationary during the wrapping operation, but advanced the capacity of an overrolling unit is significantly raised.

Abstract: A device for spreading individual tobacco leaf halves, comprising a first conveyor formed by two endless elements, the operative runs of which are in contact with one another for clamping an edge part of the tobacco leaf portion and by a second conveyor, the conveying run of which joins the side of the first conveyor and the advancing direction of which is at an acute angle to that of the first conveyor, means being provided for lifting the operative runs of the first conveyor each time apart from one another, owing to the oblique conveyance of the second conveyor, the loose part of the tobacco leaf, laying on said second conveyor, which is moved away from the first conveyor while the transverse speed component of the second conveyor ensures stretching or spreading of the tobacco leaf.

Abstract: A method and a device for stretching a tobacco leaf or portions thereof, which is distinguished in that each tobacco leaf is deposited on an omnidirectionally elastic, substantially flat carrier, pressure is exerted on the leaf on the side remote from the carrier and subsequently adequate tensile force is exerted around the leaf in a plane of the carrier in order to stretch the leaf by friction with excessive tensile force without the risk of damage of the leaf, since only the friction between the leaf and the carrier is responsible for the stretching effect.

Abstract: A method and a device for conditioning tobacco leaves or parts thereof in a coil or bobbin in which the tobacco material is conducted towards or away from a stretched belt portion of a reel, wherein a conditioning medium is continuously fed to the windings of the bobbin containing the tobacco material and to at least part of the belt portion extending away therefrom in order to control the tobacco leaf material already during winding on or off respectively of the bobbin so that the aforesaid storage and treatment conditions respectively can be better controlled.

Abstract: A method and device for emptying a belt reel or bobbin filled with tobacco leaves or portions thereof, the belt being withdrawn from the bobbin and wound on a reel, while each time the tobacco leaf portions are removed from the corresponding strip of belt, wherein prior to the removal of each tobacco leaf portion the belt is stretched in excess of the normal tensile force required for winding off the belt in order to detach the tobacco leaf portion from the belt, which additional stretching effect need only be very slight in order to pick up all tobacco leaf portions without disturbance.

Abstract: A device for storing substantially similar tobacco leaf portions in a tape reel or bobbin comprising a cutting station for cutting substantially similar leaf portions from a whole or a half tobacco leaf, a reel for winding a tape, a table for guiding and supporting the tape to be wound and a transport mechanism for transferring tobacco leaf portions from the cutting station to the supporting surface of the table, said device is provided with more than one cutting member for cutting simultaneously more than one leaf portion of the same shape, while the transport mechanism comprises an orientating member for aligning the leaf portions, in order to materially raise the production capacity of said device.

Abstract: A method and a device for cutting up a tobacco leaf into portions suitable for use as binders or wrappers, in which cutting members are employed, which have a cutting edge matching uninterruptedly the desired circumference of a wrapper or binder wherein a plurality of cutting members are arranged on a carrier in an arbitrary configuration, the tobacco leaf is spread across said number of cutting members, the tobacco leaf is divided up by the corresponding number of cutting edges and the leaf portions located within the cutting edges are removed from the cutting members, whereby the tobacco leaf is completely divided up in one run into usable and waste portions which considerably enhance the production of binders and wrappers.

Abstract: A method and a device for dividing tobacco leaves or the like into pieces, said pieces are suitable for effective and automatic processing, said method is distinguished in that the leaf is applied in a flat state on a supporting element and subsequently a co-operative counter-element is caused to vibrate, after which said elements are pressed together as a result of which a cutting edge provided on one of said elements is pressed across the tobacco material.

Abstract: The invention relates to a device for manufacturing a flap box, in which peripheral strips at the open ends of a rectangle-section box formed previously from a plano are provided with glue and subsequently bent over, after which the sidewalls of the box are cut in the longitudinal sense; the device according to the invention comprises holders having each a box, at least one gluing member adapted to move towards and away from each of said holders for applying glue to the faces of one pair of opposite peripheral strips orientated to the same side and stops adapted to move relatively to said holders for folding over in sequence one glued peripheral strip located nearest said side, the other pair of opposite peripheral strips and the other glued peripheral strip.

Abstract: A device for delivering one by one an essentially rectangular object of lenticular cross section from a pile of said objects having non-uniform, different thicknesses, said device comprising a plate supporting the pile, a stop surface standing on the supporting plate in front of one transverse edge of the objects and terminating at a given distance above the supporting plate to form a delivery gap and a catch operating in a direction towards the stop surface for conducting away the lowermost object through the gap in a direction of length wherein the improvement comprises one upright peripheral strip of the stop surface extending down to the supporting plate and at right angles to the stop surface, along the other peripheral strip thereof, a second stop surface is provided which is set back at the level of the gap over at least the width of one peripheral strip, the distance between the second stop surface and one peripheral strip being smaller than the width of the object; and a pressing member acting substa