Patents Assigned to PMT Biolabs Inc
  • Lysine monomethylated derivative and corresponding antibody and use thereof
    Patent number: 11965889
    Abstract: The present invention relates to artificially synthesized modified mono-methylated lysines and modified mono-methylated lysine derivatized polypeptides. The present invention also relates to production of a completely new antibody by using this modified mono-methylated lysine and modified mono-methylated lysine derivatized polypeptide as an antigen, this antibody can be used in recognizing and enriching the modified polypeptide after the lysine mono-methylated polypeptide being derivatized in vitro. By using this antibody, it is capable of detecting whether a mono-methylation modification is present in amino acids on the polypeptide sequence, the present invention also relates to a preparation method of said antibody.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: April 23, 2024
    Assignee: PMT BIOLABS INC
    Inventor: Zhongyi Cheng
  • Lysine monomethylated derivative and corresponding antibody and use thereof
    Patent number: 10551390
    Abstract: Provided are artificially synthesized modified mono-methylated lysines and modified mono-methylated lysine derivatized polypeptides. Also provided is an antibody produced by using this modified mono-methylated lysine and modified monomethylated lysine derivatized polypeptide as an antigen, the antibody can be used in recognizing and enriching the modified polypeptide after the lysine mono-methylated polypeptide being derivatized in vitro. Also provided are a preparation method of said antibody, a method for identifying and quantifying the lysine mono-methylated modified substrate in cell or tissue by using proteomics approach of affinity enrichment for specific antibody and mass spectrometry.
    Type: Grant
    Filed: July 18, 2015
    Date of Patent: February 4, 2020
    Assignee: PMT Biolabs Inc.
    Inventor: Zhongyi Cheng
  • Alysine Monomethylated Derivative and Corresponding Antibody and Use Thereof
    Publication number: 20170146550
    Abstract: Provided are artificially synthesized modified mono-methylated lysines and modified mono-methylated lysine derivatized polypeptides. Also provided is an antibody produced by using this modified mono-methylated lysine and modified monomethylated lysine derivatized polypeptide as an antigen, the antibody can be used in recognizing and enriching the modified polypeptide after the lysine mono-methylated polypeptide being derivatized in vitro. Also provided are a preparation method of said antibody, a method for identifying and quantifying the lysine mono-methylated modified substrate in cell or tissue by using proteomics approach of affinity enrichment for specific antibody and mass spectrometry.
    Type: Application
    Filed: July 18, 2015
    Publication date: May 25, 2017
    Applicant: PMT Biolabs Inc
    Inventor: Zhongyi Cheng