Patents Assigned to PMV PHARMACEUTICALS
  • Methods and compounds for restoring mutant p53 function
    Patent number: 10138219
    Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: November 27, 2018
    Assignee: PMV PHARMACEUTICALS
    Inventors: Binh Vu, Romyr Dominique, Hongju Li