Patents Assigned to PNEUMA RESPIRATORY, INC.
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Publication number: 20230356253Abstract: A droplet delivery device includes an ejector plate having an overall area that includes an outer area that is solid without holes and inner, active area with holes.Type: ApplicationFiled: May 3, 2023Publication date: November 9, 2023Applicant: Pneuma Respiratory, Inc.Inventors: Michael Scoggin, Jeffrey Miller, Caley Modlin, Chao-Ping Lee, Jianqiang Li
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Patent number: 11793945Abstract: A droplet delivery device includes a housing with a mouthpiece port or outlet from a nasal device for releasing fluid droplets, a fluid reservoir, and an ejector bracket having a membrane positioned between a mesh with a plurality of openings and a vibrating member that is coupled to an electronic transducer, such as an ultrasonic transducer. The transducer vibrates the vibrating member which causes the membrane to push fluid supplied by the reservoir through the mesh to generate droplets in an ejected stream released through the outlet.Type: GrantFiled: June 22, 2022Date of Patent: October 24, 2023Assignee: Pneuma Respiratory, Inc.Inventors: Charles Eric Hunter, Michael Scoggin, Jeffrey Miller, Jose Salazar, Brian Beach, Caley Modlin, Matthew Culpepper, Jianqiang Li, Chengjie Li, Shi Bo Wang, Chao-Ping Lee, Gregory Rapp, Judson Sidney Clements
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Publication number: 20230330362Abstract: A dry powder aerosol delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The dry powder aerosol delivery device includes a housing, a cartridge, and a dry powder dispersion mechanism, and at least one differential pressure sensor. The dry powder delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The dry powder aerosol delivery device is then actuated to generate a plume of particles having an average ejected particle diameter within the respirable size range, e.g., less than about 5-6 ?m, so as to target the pulmonary system of the user.Type: ApplicationFiled: December 13, 2022Publication date: October 19, 2023Applicant: PNEUMA RESPIRATORY, INC.Inventors: Charles Eric Hunter, John H. Hebrank, Louis Thomas Germinario
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Patent number: 11771852Abstract: A droplet delivery device with a small volume drug ampoule and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device is configured to facilitate the ejection of small, e.g., single use, volumes of a therapeutic agent. The droplet delivery device includes a housing, a mouthpiece, a small volume drug ampoule, an ejector mechanism, and at least one differential pressure sensor. The delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 ?m, so as to target the pulmonary system of the user.Type: GrantFiled: November 8, 2018Date of Patent: October 3, 2023Assignee: PNEUMA RESPIRATORY, INC.Inventors: John H. Hebrank, Christopher W. Maurer, Charles Eric Hunter, Chengjie Li, Louis Thomas Germinario
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Publication number: 20230286008Abstract: A droplet delivery device includes an ejector mechanism with an ejector mesh or similar substrate with apertures that is treated by one or more of coatings, roughening, metal layer deposition and laser ablation to provide desirable production and size of droplets, such as in an inhaled aerosol from the device.Type: ApplicationFiled: March 9, 2023Publication date: September 14, 2023Applicant: Pneuma Respiratory, Inc.Inventors: Charles Eric Hunter, Matthew Culpepper, Michael Scoggin, Caley Modlin, Jeffrey Miller, Jose Salazar, Cristian Salazar, Gregory Rapp, Jacob Greenfield
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Publication number: 20230277781Abstract: A device and method for delivering a fluid as an ejected stream of droplets during inhalation uses inertial filtering to cause a first plurality of droplet particles generated by an ejector mechanism to pass through an airflow exit while a second plurality of droplet particles having a greater mass mean aerodynamic diameter than the first plurality of droplet particles fails to pass through the airflow exit.Type: ApplicationFiled: February 15, 2023Publication date: September 7, 2023Applicant: PNEUMA RESPIRATORY, INC.Inventors: Louis Thomas Germinario, John H. Hebrank, Charles Eric Hunter, Jack C. Hunter, Chengjie Li, Christopher W. Maurer
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Patent number: 11738158Abstract: An in-line droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The in-line droplet delivery device includes a housing, a mouthpiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The in-line droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The in-line droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 ?m, so as to target the pulmonary system of the user. the droplet delivery device is configured in an in-line orientation in that the housing, its internal components, and various device components (e.g., the mouthpiece, air inlet flow element, etc.) are orientated in a substantially in-line or parallel configuration (e.g.Type: GrantFiled: October 4, 2018Date of Patent: August 29, 2023Assignee: Pneuma Respiratory, Inc.Inventors: John H. Hebrank, Charles Eric Hunter, Christopher W. Maurer, Chengjie Li, Louis Thomas Germinario
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Publication number: 20230000150Abstract: A droplet delivery device with an ejector mechanism and fluid reservoir includes an accelerometer to determine and communicate optimized mixing of fluid in the reservoir for inhalation of droplets, such as into the lungs, from the droplet delivery device.Type: ApplicationFiled: June 29, 2022Publication date: January 5, 2023Applicant: PNEUMA RESPIRATORY, INC.Inventors: John H. Hebrank, Judson Sidney Clements
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Publication number: 20220401661Abstract: A droplet delivery device includes a housing with a mouthpiece port or outlet from a nasal device for releasing fluid droplets, a fluid reservoir, and an ejector bracket having a membrane positioned between a mesh with a plurality of openings and a vibrating member that is coupled to an electronic transducer, such as an ultrasonic transducer. The transducer vibrates the vibrating member which causes the membrane to push fluid supplied by the reservoir through the mesh to generate droplets in an ejected stream released through the outlet.Type: ApplicationFiled: June 22, 2022Publication date: December 22, 2022Applicant: PNEUMA RESPIRATORY, INC.Inventors: Charles Eric Hunter, Michael Scoggin, Jeffrey Miller, Jose Salazar, Brian Beach, Caley Modlin, Matthew Culpepper, Jianqiang Li, Chengjie Li, Shi Bo Wang, Chao-Ping Lee, Gregory Rapp, Judson Sidney Clements
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Patent number: 11529476Abstract: A dry powder aerosol delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The dry powder aerosol delivery device includes a housing, a cartridge, and a dry powder dispersion mechanism, and at least one differential pressure sensor. The dry powder delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The dry powder aerosol delivery device is then actuated to generate a plume of particles having an average ejected particle diameter within the respirable size range, e.g., less than about 5-6 ?m, so as to target the pulmonary system of the user.Type: GrantFiled: May 21, 2018Date of Patent: December 20, 2022Assignee: Pneuma Respiratory, Inc.Inventors: Charles Eric Hunter, John H. Hebrank, Louis Thomas Germinario
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Patent number: 11458267Abstract: A nasal droplet delivery device and related methods for delivering precise and repeatable dosages to a subject via the nasal passageways and sinus cavities is disclosed. The droplet delivery device includes a housing, a nosepiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically actuated by the user when the differential pressure sensor senses a predetermined pressure change within the nosepiece. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter of greater than about 6 microns, preferably greater than about 10 micron, so as to target the nasal passageways and sinus cavities of the user.Type: GrantFiled: October 17, 2018Date of Patent: October 4, 2022Assignee: PNEUMA RESPIRATORY, INC.Inventors: John H. Hebrank, Christopher W. Maurer, Charles Eric Hunter, Chengjie Li, Louis Thomas Germinario
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Publication number: 20220296823Abstract: An ejector mechanism, droplet delivery device and related methods or delivering small droplets to the respiratory system of a users disclosed. The ejector mechanism comprises a piezoelectric actuator and an aperture plate, the aperture plate having and a plurality of openings formed through its thickness, wherein at least the fluid entrance side of one or more of said openings is configured to provide a surface contact angle of less than 90 degrees and the piezoelectric actuator is operable to oscillate the aperture plate at a frequency to thereby generate an ejected stream of droplets during use. The droplet delivery device is automatically breath actuated by a user when the differential pressure sensor senses a predetermined pressure change. The ejector mechanism is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range having a diameter of less than about 4 um so as to target the respiratory system of the user.Type: ApplicationFiled: June 29, 2020Publication date: September 22, 2022Applicant: Pneuma Respiratory, Inc.Inventors: John H. Hebrank, Charles Eric Hunter, Matthew Culpepper, Judson Sidney Clements
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Publication number: 20220226587Abstract: An ultrasonic droplet delivery device and related methods for delivering precise and repeatable amounts of a substance to a user for respiratory use is disclosed. The ultrasonic droplet delivery device generally comprises a body housing, a mouthpiece having an ejector mechanism, and a fluid cartridge having at least one fluid reservoir. In certain embodiments, the ejector mechanism may comprise at least one ultrasonic actuator and at least one aperture plate with a plurality of openings formed through its thickness for ejecting droplets. The device may further comprise at least one differential pressure sensor configured to activate the ejector mechanism upon sensing a pre-determined pressure change within the device to thereby generate the ejected stream of droplets.Type: ApplicationFiled: May 11, 2020Publication date: July 21, 2022Applicant: Pneuma Respiratory, Inc.Inventors: Charles Eric HUNTER, John H. HEBRANK, Chengjie LI, Judson Sidney CLEMENTS
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Patent number: 11285285Abstract: A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 ?m, so as to target the pulmonary system of the user.Type: GrantFiled: May 3, 2017Date of Patent: March 29, 2022Assignee: Pneuma Respiratory, Inc.Inventors: Louis Thomas Germinario, John H. Hebrank, Charles Eric Hunter, Thomas P. Stern, Jack C. Hunter
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Patent number: 11285284Abstract: A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 ?m, so as to target the pulmonary system of the user.Type: GrantFiled: May 3, 2017Date of Patent: March 29, 2022Assignee: Pneuma Respiratory, Inc.Inventors: Louis Thomas Germinario, John H. Hebrank, Charles Eric Hunter, Thomas P. Stern
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Patent number: 11285283Abstract: A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 ?m, so as to target the pulmonary system of the user.Type: GrantFiled: May 3, 2017Date of Patent: March 29, 2022Assignee: Pneuma Respiratory, Inc.Inventors: Louis Thomas Germinario, John H. Hebrank, Charles Eric Hunter, Jack C. Hunter, Chengjie Li, Christopher W. Maurer
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Patent number: 11285274Abstract: A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 ?m, so as to target the pulmonary system of the user.Type: GrantFiled: May 3, 2017Date of Patent: March 29, 2022Assignee: Pneuma Respiratory, Inc.Inventors: Louis Thomas Germinario, John H. Hebrank, Charles Eric Hunter, Thomas P. Stern
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Publication number: 20220080137Abstract: Methods, devices and systems are provided wherein compositions are delivered to the pulmonary system of an intended user via inhalation in a controlled manner and at a desired doses and/or amounts, e.g., within a desired dosage window and/or inhalation topography. In certain embodiments, dosage windows and/or inhalation topography may be used, e.g., to provide for controlled cessation of use or to provide a desired therapeutic window.Type: ApplicationFiled: January 23, 2020Publication date: March 17, 2022Applicant: Pneuma Respiratory, Inc.Inventors: John H. Hebrank, Charles Eric Hunter
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Publication number: 20220008669Abstract: A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 ?m, so as to target the pulmonary system of the user.Type: ApplicationFiled: January 22, 2021Publication date: January 13, 2022Applicant: Pneuma Respiratory, Inc.Inventors: Louis Thomas Germinario, John H. Hebrank, Charles Eric Hunter, Jack C. Hunter, Chengjie Li, Christopher W. Maurer
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Publication number: 20210275760Abstract: A dry powder aerosol delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The dry powder aerosol delivery device includes a housing, a cartridge, and a dry powder dispersion mechanism, and at least one differential pressure sensor. The dry powder delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The dry powder aerosol delivery device is then actuated to generate a plume of particles having an average ejected particle diameter within the respirable size range, e.g., less than about 5-6 ?m, so as to target the pulmonary system of the user.Type: ApplicationFiled: May 21, 2018Publication date: September 9, 2021Applicant: PNEUMA RESPIRATORY, INC.Inventors: Charles Eric Hunter, John H. Hebrank, Louis Thomas Geminario