Patents Assigned to PNEUMRX, Inc.
  • Publication number: 20200155165
    Abstract: A system for treating a genetically associated chronic obstructive pulmonary disease. The system includes a coil implant, wherein the coil implant is configured to increase tension of a lung having alveolar damage caused by a genetic disorder and thereby improve breathing function of the lung. The system includes a delivery system configured to deliver the coil implant into an airway of the lung, wherein the delivery system comprises a cartridge configured to retain the coil implant in a straight configuration. The coil implant is configured to recover to a non-straight, pre-determined shape upon deployment within the airway the lung of the patient.
    Type: Application
    Filed: December 10, 2019
    Publication date: May 21, 2020
    Applicant: PneumRx, Inc.
    Inventors: Mark L. Mathis, Kara Andersen Reiter
  • Publication number: 20200146688
    Abstract: Embodiments include a transition section for coupling a distal section and a proximal section of the guidewire. The transition section includes a main body having a first outer diameter; proximal and distal pin extensions having second and third outer diameters, wherein the proximal pin extension is configured to be fixed to the proximal section of the guidewire, and the distal pin extension is configured to be inserted into and fixed to the distal section of the guidewire. The distal pin extension includes a bore for receiving an inner core of the distal section of the guidewire. The first outer diameter may be greater than the second and third outer diameters. Also disclosed are methods of manufacturing a guidewire with such a transition section.
    Type: Application
    Filed: January 15, 2020
    Publication date: May 14, 2020
    Applicant: PneumRx, Inc.
    Inventors: Timothy Machold, Mark Mathis, Verna Rodriguez, Scott Kaarto
  • Patent number: 10555736
    Abstract: Guidewires suitable for use in a system for implanting a lung volume reduction device are disclosed. The guidewire includes an outer sheath having proximal and distal ends, and comprising a proximal section, a transition section, and a distal section. The proximal section extends from the proximal end of the sheath to the transition section, and the distal section extends from the transition section to the distal end of the sheath. The distal section defines a bore extending from the transition section to the distal end of the sheath and an inner core having proximal and distal ends. The inner core extends through the bore of the distal section of the sheath, wherein the inner core is fixed to the sheath at the transition section, and wherein the distal end of the inner core is fixed to the distal end of the sheath at the distal end of the sheath.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: February 11, 2020
    Assignee: PneumRx, Inc.
    Inventors: Timothy Machold, Mark Mathis, Verna Rodriguez, Scott Kaarto
  • Patent number: 10543053
    Abstract: A container for a medical device having a housing defining a cavity for receiving a device, such as a lung volume reduction coil, is disclosed. In some embodiments, the container includes a coupling zone external to the cavity, an exit aperture between the cavity and the coupling zone, and a bearing surface located within the cavity, the bearing surface, exit aperture and coupling zone defining an exit path along which the device can be moved for deployment from the container. The bearing surface is spaced from the exit aperture and arranged, together with the coupling zone, such that the exit path is substantially straight. In some embodiments, the cavity may be approximately cylindrical, and the bearing surface, the exit aperture, and the coupling zone are aligned such that the exit path extends in a direction that is substantially tangential to the cavity.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: January 28, 2020
    Assignee: PneumRx, Inc.
    Inventors: David Lehrberg, Jeffrey W. Etter, Mark L. Mathis, Verna Rodriguez
  • Patent number: 10537334
    Abstract: A method for treating a genetically associated chronic obstructive pulmonary disease. At least one implant is advanced into an airway of a lung having a genetically associated chronic obstructive pulmonary disease. The at least one implant is delivered into the lung to increase tension of the lung and thereby improve breathing function of the lung.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: January 21, 2020
    Assignee: PneumRx, Inc.
    Inventors: Mark L. Mathis, Kara Andersen Reiter
  • Publication number: 20190350588
    Abstract: The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. The invention includes methods, systems, and devices for applying a first lung volume reduction action to the functionally impaired lung tissue so as to reduce its volume to less than a pre-treatment volume; and applying a pro-inflammatory stimulus to the functionally impaired lung tissue having reduced volume, that stimulus being sufficient to induce fibrosis in the functionally impaired lung tissue. The pro-inflammatory stimulus may be separate and additional to that of the lung volume reduction action.
    Type: Application
    Filed: May 20, 2019
    Publication date: November 21, 2019
    Applicant: PneumRx, Inc.
    Inventors: Verna Rodriguez, Kinman Hong
  • Patent number: 10390838
    Abstract: The present invention generally provides improved medical devices, systems, and methods, particularly for treating one or both lungs of a patient with an implant, such as a coil, having a strength tuned to a patient's tissue treatment region. More particularly, embodiments of the present invention include a method for treating a lung of a patient with chronic obstructive pulmonary disease. The method comprises determining a regional tissue density of at least a portion of lung tissue of the patient and selecting between first and second coils based on the determined regional tissue density of the portion of lung tissue. In particular, the first coil has a first austenite final tuning and second coil has a second austenite final tuning different than the first tuning. Determining may comprise imaging at least the portion of lung tissue of the patient so as to identify a localized lung tissue density.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: August 27, 2019
    Assignee: PneumRx, Inc.
    Inventors: Mark Mathis, Verna Rodriguez
  • Publication number: 20190216466
    Abstract: A lung volume reduction system is disclosed comprising an implantable device adapted to be delivered to a lung airway of a patient in a delivery configuration and to change to a deployed configuration to bend the lung airway. The invention also discloses a method of bending a lung airway of a patient comprising inserting a device into the airway in a delivery configuration and bending the device into a deployed configuration, thereby bending the airway.
    Type: Application
    Filed: March 25, 2019
    Publication date: July 18, 2019
    Applicant: PneumRx, Inc.
    Inventors: Mark L. Mathis, David Thompson, Patrick Wu
  • Publication number: 20190150936
    Abstract: The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. A lung volume reduction system includes an implantable device having an elongate body that is sized and shaped for delivery via the airway system to a lung airway of a patient. The implant is inserted and positioned while the implant is in a delivery configuration, and is reconfigured to a deployed configuration so as to locally compress adjacent tissue of the lung, with portions of the elongate body generally moving laterally within the airway so as to laterally compress lung tissue. A plurality of such implants will often be used to treat a lung of a patient.
    Type: Application
    Filed: January 24, 2019
    Publication date: May 23, 2019
    Applicant: PneumRx, Inc.
    Inventors: Mark L. Mathis, David Thompson, Nathan Aronson, Patrick Wu
  • Patent number: 10285707
    Abstract: A lung volume reduction system is disclosed comprising an implantable device adapted to be delivered to a lung airway of a patient in a delivery configuration and to change to a deployed configuration to bend the lung airway. The invention also discloses a method of bending a lung airway of a patient comprising inserting a device into the airway in a delivery configuration and bending the device into a deployed configuration, thereby bending the airway.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: May 14, 2019
    Assignee: PneumRx, Inc.
    Inventors: Mark L. Mathis, David Thompson, Patrick Wu
  • Patent number: 10226257
    Abstract: The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. A lung volume reduction system includes an implantable device having an elongate body that is sized and shaped for delivery via the airway system to a lung airway of a patient. The implant is inserted and positioned while the implant is in a delivery configuration, and is reconfigured to a deployed configuration so as to locally compress adjacent tissue of the lung, with portions of the elongate body generally moving laterally within the airway so as to laterally compress lung tissue. A plurality of such implants will often be used to treat a lung of a patient.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: March 12, 2019
    Assignee: PneumRx, Inc.
    Inventors: Mark L. Mathis, David Thompson, Nathan Aronson, Patrick Wu
  • Patent number: 10188397
    Abstract: A device for enhancing the breathing efficiency of a patient is provided. The implantable device may include a deployed configuration with one or more helical sections with proximal end in a stand-off proximal end configuration. The stand-off proximal end configuration may reduce migration of the deployed device and may preserve implant tissue compression. Alternative configurations may include two or more helical sections with a transition section disposed between the two or more helical sections. A device may include a right-handed helical section and a left-handed helical section and the transition section comprises a switchback transition section. The switchback section may provide greater control of the device during deployment by limiting recoiling forces of a device comprising a spring material. The deployed device may compress the lung to increase a gas filling resistance of the compressed portion of the lung, and/or increase tension and elastic recoil in other portions of the lung.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: January 29, 2019
    Assignee: PneumRx, Inc.
    Inventors: Jaime Vasquez, Mark L. Mathis, Timothy Machold, Andrew Stein
  • Patent number: 10188398
    Abstract: Elongate implant structures can be introduced into an airway system to a target airway axial region, often to apply lateral bending and/or compression forces against the lung tissue from within the airways for an extended period of time. Structures or features of the implants may inhibit tissue reactions that might otherwise allow portions of the device to eventually traverse through the wall of the airway. The devices may enhance the area bearing laterally on the tissue of a surrounding airway lumen wall. Embodiments may have features which increase the device friction with the airway to allow the device to grip the surrounding airway as the device is deployed. An appropriate adhesive may be introduced around the device in the lung. Hydrophilic material may inhibit biofilm formation, or features which induce some tissue ingrowth (stimulation of tissue growth) may enhance implanted device supported.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: January 29, 2019
    Assignee: PneumRx, Inc.
    Inventors: Mark L. Mathis, Patrick Wu, David Lehrberg, Jaime Vasquez, Erin McGurk, Ronald Dieck, Andrew Stein
  • Patent number: 10166041
    Abstract: This invention relates to device, systems, kits and methods that enable selective dissection of lung tissue to remove diseased tissue from healthy tissue without damaging blood vessels or airways. The invention and methods enable minimally invasive lung surgery procedures by providing a device and method to perform automated dissection that discriminates against traumatizing critical lung tissue.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: January 1, 2019
    Assignee: PneumRx, Inc.
    Inventors: Mark L. Mathis, Amelia Lasser, David Lehrberg
  • Patent number: 10058331
    Abstract: A lung volume reduction system is disclosed having an implantable device adapted to be delivered to a lung airway of a patient in a delivery configuration and to change to a deployed configuration to bend the lung airway. The invention also discloses a method of bending a lung airway of a patient by inserting a device into the airway in a delivery configuration and bending the device into a deployed configuration, thereby bending the airway.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: August 28, 2018
    Assignee: PneumRx, Inc.
    Inventors: Mark L. Mathis, David Thompson, Patrick Wu
  • Patent number: 10034999
    Abstract: A variety of steerable needles, lancets, trocars, stylets, cannulas and systems are provided for examining, diagnosing, treating, or removing tissue from a patient. The steerable needles, trocars, stylets, cannulas and systems also provide a platform for delivery of target materials, such as therapeutics, biologics, polymes, glues, etc., to a target site. An embodiment of the invention includes a steerable device for use in accessing target site in a patient comprising: a steerable member adapted to penetrate tissue; and a steering mechanism adapted to be operated by a user to apply a bending force to bend the steerable member to access the target site.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: July 31, 2018
    Assignee: PneumRx, Inc.
    Inventors: Mark Mathis, David Thompson, Bruce Addis, David F. Yankelevitz
  • Patent number: 9839408
    Abstract: Minimally invasive systems and methods are described for measuring pulmonary circulation information from the pulmonary arteries. A transbronchial Doppler ultrasound catheter is advanced through the airways and in the vicinity of the pulmonary artery. Doppler ultrasound energy is sent through the airway wall and across the pulmonary artery to obtain velocity information of blood flowing through the artery. The velocity information is used to compute pulmonary circulation information including but not limited to flowrate.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: December 12, 2017
    Assignee: PneumRx, Inc.
    Inventors: Edmund J. Roschak, Jeffrey Schwardt, Philip Stephen Levin
  • Patent number: 9801637
    Abstract: A method for treating a genetically associated chronic obstructive pulmonary disease. At least one implant is advanced into an airway of a lung having a genetically associated chronic obstructive pulmonary disease. The at least one implant is delivered into the lung to increase tension of the lung and thereby improve breathing function of the lung.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: October 31, 2017
    Assignee: PneumRx, Inc.
    Inventors: Mark L. Mathis, Kara Andersen Reiter
  • Patent number: D818700
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: May 29, 2018
    Assignee: PneumRx, Inc.
    Inventors: David Lehrberg, Jeffrey W. Etter
  • Patent number: RE47231
    Abstract: The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an adhering moiety coupled to one or more other moieties including, for example, a cross-linkable moiety and/or one other adhering moiety. The methods and compositions of the invention find use, for example, in treating pulmonary conditions, such as emphysema.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: February 12, 2019
    Assignee: PneumRx, Inc.
    Inventors: Glen Gong, Ronald Dieck