Patents Assigned to Pocared Diagnostics Ltd.
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Patent number: 11002752Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a cooling, heating and fan arrangement for maintaining a predetermined optimum temperature of the samples during testing; a visual, circumferential and axial alignment system for aligning the samples within the carousel; a transfer system for transferring the samples from the carousel to the centrifuge; a balancing system of minimizing the rotational vibrations of the centrifuge; a safety system and anti-tipping design for the sample containing system; liquid dispensing arms for dispensing the buffered saline solution; and discharge ports for discharging and disposing of the liquid removed from the samples to a location external of the system.Type: GrantFiled: March 22, 2019Date of Patent: May 11, 2021Assignees: POCARED Diagnostics LTD., Battelle Memorial InstituteInventors: Gal Ingber, William G. Atterbury, Dave Holley, Thomas A. Klausing, John S. Laudo, Jason A. Schaefer, Sherwood Talbert, John Tallarico
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Patent number: 10905978Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.Type: GrantFiled: October 16, 2018Date of Patent: February 2, 2021Assignee: POCARED Diagnostics LTD.Inventors: Jonathan Gurfinkel, Gal Ingber
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Patent number: 10801962Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.Type: GrantFiled: August 8, 2018Date of Patent: October 13, 2020Assignee: POCARED Diagnostics LTD.Inventors: Gal Ingber, William G. Atterbury, Dave Holley, Thomas A. Klausing, John S. Laudo, Jason A. Schaefer, Sherwood Talbert, John Tallarico
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Patent number: 10739237Abstract: An apparatus for processing a biological sample for optical analysis having a cartridge with a sample supply container and a couvette, a cartridge/magazine holding the cartridge, and a cassette fan positioned over the cartridge. A filter cassette is mounted within the cassette fan, wherein the filter cassette has an inlet for receiving a sample from the sample supply container, an outlet for discharging the filter sample into the couvette, and valves therein to manipulate the sample for filtering. A cassette clamp is positioned over the filter cassette to secure the cassette and operate the filter cassette. A method for implementing this apparatus is also described herein. Additionally an apparatus is used for and a method measures waste fluid that passes over a filter element to control the amount of rinse fluid passing over the filter element.Type: GrantFiled: August 2, 2018Date of Patent: August 11, 2020Assignee: POCARED Diagnostics LTD.Inventor: Gal Ingber
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Patent number: 10731123Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria, in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optics cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light. The system may utilize the disposable cartridge in the sample processor and the optics cup or cuvette in the optical analyzer, wherein the optics cup also has a floor in the shape of an inverted arch.Type: GrantFiled: November 28, 2017Date of Patent: August 4, 2020Assignee: POCARED Diagnostics LTD.Inventors: Gal Ingber, Martha J. Rogers
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Patent number: 10656140Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.Type: GrantFiled: February 6, 2017Date of Patent: May 19, 2020Assignee: POCARED Diagnostics LTD.Inventors: Gal Ingber, William G. Atterbury, Russell H. Barnes, Douglas E. Boyd, Joseph D. Dennis, Jonathan Gurfinkel, Dave Holley, Steven E. Huckaby, Thomas A. Klausing, John S. Laudo, Kevin Sadeski, Jason A. Schaefer, K. Bryan Scott, Carol Stillman, Sherwood Talbert, John Tallarico
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Patent number: 10288632Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a cooling, heating and fan arrangement for maintaining a predetermined optimum temperature of the samples during testing; a visual, circumferential and axial alignment system for aligning the samples within the carousel; a transfer system for transferring the samples from the carousel to the centrifuge; a balancing system of minimizing the rotational vibrations of the centrifuge; a safety system and anti-tipping design for the sample containing system; liquid dispensing arms for dispensing the buffered saline solution; and discharge ports for discharging and disposing of the liquid removed from the samples to a location external of the system.Type: GrantFiled: September 20, 2010Date of Patent: May 14, 2019Assignee: POCARED DIAGNOSTICS LTD.Inventors: Gal Ingber, William G. Atterbury, Dave Holley, Thomas A. Klausing, John S. Laudo, Jason A. Schaefer, Sherwood Talbert, John Tallarico
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Patent number: 10188967Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.Type: GrantFiled: December 4, 2014Date of Patent: January 29, 2019Assignee: POCARED DIAGNOSTICS LTD.Inventors: Gal Ingber, Scott Castanon
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Patent number: 10130902Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.Type: GrantFiled: December 4, 2014Date of Patent: November 20, 2018Assignee: POCARED DIAGNOSTICS LTD.Inventors: Jonathan Gurfinkel, Gal Ingber
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Patent number: 10082452Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. In an intermediate step, the particles captured by the filter may be rinsed with a rinsing fluid such as water to pass additional undersized particles through the filter, thereby providing a purer sample. To improve efficiency, check valves may be used for passageways with one-way flow. Additionally, a configuration of three-way stopcocks may also be utilized. Finally, a sandwich arrangement is possible, wherein a single bottom element is sandwiched between two opposing top elements.Type: GrantFiled: February 4, 2014Date of Patent: September 25, 2018Assignee: POCARED Diagnostics LTD.Inventor: Gal Ingber
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Patent number: 10073036Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.Type: GrantFiled: November 2, 2016Date of Patent: September 11, 2018Assignee: POCARED Diagnostics LTD.Inventors: Gal Ingber, William G. Atterbury, Dave Holley, Thomas A. Klausing, John S. Laudo, Jason A. Schaefer, Sherwood Talbert, John Tallarico
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Patent number: 10018564Abstract: This invention relates to a method that allows for the differentiation of isolates of commonly encountered bacteria that contain specific antibiotic-resistance genes from similar isolates that do not harbor the gene. More particularly, the invention relates to a method that utilizes an automated rapid platform system that employs intrinsic fluorescence, optical data analysis, and artificial intelligence methods to analyze multi-dimensional optical characteristics of bacterial strains.Type: GrantFiled: March 4, 2016Date of Patent: July 10, 2018Assignee: POCARED DIAGNOSTICS LTD.Inventors: Jonathan Gurfinkel, Gal Ingber
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Patent number: 9862920Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria, in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optics cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light. The system may utilize the disposable cartridge in the sample processor and the optics cup or cuvette in the optical analyzer, wherein the optics cup also has a floor in the shape of an inverted arch.Type: GrantFiled: December 11, 2013Date of Patent: January 9, 2018Assignee: POCARED DIAGNOSTICS LTD.Inventors: Gal Ingber, Martha J. Rogers
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Patent number: 9778171Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light, an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.Type: GrantFiled: December 21, 2016Date of Patent: October 3, 2017Assignee: POCARED DIAGNOSTICS LTD.Inventor: Gal Ingber
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Patent number: 9606105Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.Type: GrantFiled: July 14, 2014Date of Patent: March 28, 2017Assignee: POCARED DIAGNOSTICS LTD.Inventors: Gal Ingber, William G. Atterbury, Russell H. Barnes, Douglas E. Boyd, Joseph D. Dennis, Jonathan Gurfinkel, Dave Holley, Steven E. Huckaby, Thomas A. Klausing, Kevin Sadeski, Jason A. Schaefer, K. Bryan Scott, Carol Stillman, Sherwood Talbert, John Tallarico, John S. Laudo
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Patent number: 9581541Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light, an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.Type: GrantFiled: July 15, 2014Date of Patent: February 28, 2017Assignee: POCARED DIAGNOSTICS LTD.Inventor: Gal Ingber
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Patent number: 9506866Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.Type: GrantFiled: August 6, 2013Date of Patent: November 29, 2016Assignee: POCARED Diagnostics LTD.Inventors: Gal Ingber, William G. Atterbury, Dave Holley, John S. Laudo, Jason A. Schaefer, Sherwood Talbert, John Tallarico, Thomas A. Klausing
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Publication number: 20140246389Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. In an intermediate step, the particles captured by the filter may be rinsed with a rinsing fluid such as water to pass additional undersized particles through the filter, thereby providing a purer sample. To improve efficiency, check valves may be used for passageways with one-way flow. Additionally, a configuration of three-way stopcocks may also be utilized. Finally, a sandwich arrangement is possible, wherein a single bottom element is sandwiched between two opposing top elements.Type: ApplicationFiled: February 4, 2014Publication date: September 4, 2014Applicant: POCARED Diagnostics LTD.Inventor: Gal Ingber
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Patent number: 8808649Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.Type: GrantFiled: October 10, 2008Date of Patent: August 19, 2014Assignee: Pocared Diagnostics Ltd.Inventors: Gal Ingber, William G. Atterbury, Russell H. Barnes, Douglas E. Boyd, Joseph D. Dennis, Jonathan Gurfinkel, Dave Holley, Steven E. Huckaby, Thomas A. Klausing, John S. Laudo, Kevin Sadeski, Jason A. Schaefer, K. Bryan Scott, Carol Stillman, Sherwood Talbert, John Tallarico
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Patent number: 8804114Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light, an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.Type: GrantFiled: November 1, 2011Date of Patent: August 12, 2014Assignee: Pocared Diagnostics Ltd.Inventor: Gal Ingber