Patents Assigned to Pola Chemical Industries Inc., Japan
  • Pyrrolo(3,2-e)pyrazolo(1,5-a)pyrimidine derivative and medicine comprising the same
    Patent number: 4992442
    Abstract: Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidine derivatives are disclosed. The compounds are represented by the formula (I), ##STR1## wherein R.sub.1 and R.sub.2 individually represent a hydrogen atom, a linear or branched alkyl group which may have a substituent, a cycloalkyl or phenyl group which may have a substituent, or a heterocyclic group which may have a substituent, and R.sub.3 is a hydrogen atom or a cyano group. The compounds have excellent circulatory disease curing activities as well as bronchodilation activities.
    Type: Grant
    Filed: October 3, 1989
    Date of Patent: February 12, 1991
    Assignee: Pola Chemical Industries Inc., Japan
    Inventors: Michihiko Tsujitani, Kenichi Kishii, Masato Inazu, Toshihiro Morimoto, Yoshiaki Motoki, Ichiro Matsuo
  • Heterocyclic derivatives and radiosensitizing agents and antiviral agents comprising same as their active component
    Patent number: 4945102
    Abstract: A novel heterocyclic derivative of formula (I): ##STR1## wherein R.sub.1 represents ##STR2## and R.sub.2 represents hydrogen or acyl. When R.sub.2 is acyl, the derivative can be prepared, for example, by the following process: ##STR3## wherein R.sub.4 is acyl and R.sub.1 is ##STR4## The derivative is less toxic and has radiosensitizing activity and antiviral activity even at a low concentration.Radiosensitizing agents and antiviral agents containing the derivative as active component are also disclosed.
    Type: Grant
    Filed: September 21, 1988
    Date of Patent: July 31, 1990
    Assignee: Pola Chemical Industries Inc., Japan
    Inventors: Toshimitsu Suzuki, Masakazu Sakaguchi, Yoshiyuki Miyata, Tomoyuki Mori