Patents Assigned to Polichem, S.A.
  • Patent number: 10899824
    Abstract: The present invention relates to a combination comprising HSV-1 and HSV-2 binding monoclonal antibodies or fragments thereof and antiviral agents, the pharmaceutical formulations comprising said combination, optionally together with an excipient pharmaceutically acceptable and its use in the prophylaxis and/or treatment of herpes virus infections, including genital herpes, HSV gingivostomatitis and recurrent herpes labialis, herpes simplex encephalitis (HSE), neonatal HSV, HSV disease in the immunocompromised host and HSV keratitis keratoconjunctivitis.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: January 26, 2021
    Assignee: Polichem S.A.
    Inventors: Roberto Burioni, Massimo Clementi
  • Patent number: 10626167
    Abstract: The present invention is in the field of monoclonal antibodies suitable for passive immunotherapy of Herpes Simplex Virus infections and relates to human monoclonal antibodies or fragments of said antibodies, which bind and neutralize HSV-1 and HSV-2, and their use in the prophylaxis or treatment of HSV-1 or HSV-2-associated diseases.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: April 21, 2020
    Assignee: POLICHEM S.A.
    Inventors: Roberto Burioni, Massimo Clementi, Daniela Concas
  • Publication number: 20190185546
    Abstract: The present invention relates to a combination comprising HSV-1 and HSV-2 binding monoclonal antibodies or fragments thereof and antiviral agents, the pharmaceutical formulations comprising said combination, optionally together with an excipient pharmaceutically acceptable and its use in the prophylaxis and/or treatment of herpes virus infections, including genital herpes, HSV gingivostomatitis and recurrent herpes labialis, herpes simplex encephalitis (HSE), neonatal HSV, HSV disease in the immunocompromised host and HSV keratitis keratoconjunctivitis.
    Type: Application
    Filed: July 26, 2017
    Publication date: June 20, 2019
    Applicant: Polichem S.A.
    Inventors: Roberto Burioni, Massimo Clementi
  • Publication number: 20160213651
    Abstract: The present invention relates to a novel use of the active ingredient Pidotimod, or its stereoisomers and/or physiologically acceptable salts thereof, to treat inflammation-associated diseases characterized by an aberrant hyperactivation of the non canonical NFkB pathway, such as allergic diseases, autoimmune diseases or other inflammatory diseases based on mechanisms different from allergic or autoimmune.
    Type: Application
    Filed: September 8, 2014
    Publication date: July 28, 2016
    Applicant: POLICHEM S.A.
    Inventors: Arnaldo Caruso, Simona Fiorentini
  • Publication number: 20160213705
    Abstract: The present invention is directed to a method to treat onychomycosis by topically administering a composition which contains hydroxypropyl chitosan as the sole active ingredient and, in particular, by administering a nail topical composition consisting essentially of: a) hydroxypropyl chitosan, b) water, c) at least a lower alkanol.
    Type: Application
    Filed: September 8, 2014
    Publication date: July 28, 2016
    Applicant: POLICHEM S.A.
    Inventors: Federico Mailland, Maurizio Caserini, Daniela Ceriani
  • Patent number: 8318214
    Abstract: Method for the treatment of onychoschizia in a patient having onychoschizia. The method is performed by administering to the patient a topical composition including (a) at least one herb extract from the genus Equisetum, and (b) at least one water-soluble film forming agent which is a derivative of chitosan.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: November 27, 2012
    Assignee: Polichem S.A.
    Inventor: Federico Mailland
  • Publication number: 20110091555
    Abstract: A hydrophilic matrix is disclosed which comprises: a) at least one polyacrylic acid derivative in preferred amounts of 0.5-40%, b) at least one cellulose ether in preferred amounts of 30-90% and c) at least one disintegrant in preferred amounts of 2-50%, with respect to the weight of the matrix. This matrix is used in combination with at least one pharmaceutically acceptable active principle for manufacturing solid bioadhesive controlled release formulations for the treatment of vaginal disorders, such as vulvovaginal candidiasis, bacterial vaginosis or trichomoniasis. According to a preferred embodiment, the matrix is used in amounts of about 5-60% and the active principle in amounts of about 2-70%, with respect to the weight of the formulation.
    Type: Application
    Filed: July 21, 2007
    Publication date: April 21, 2011
    Applicant: POLICHEM S.A.
    Inventors: Stefano De Luigi Bruschi, Federico Mailland
  • Patent number: 7863326
    Abstract: Method for prevention and treatment of vaginal fungal infections by administering a formulation comprising ascorbic acid or a physiologically acceptable salt thereof to a patient in need of such prevention or treatment. The formulation is administered after completion of the standard treatment against bacterial, fungal or protozoarian infections.
    Type: Grant
    Filed: May 21, 2004
    Date of Patent: January 4, 2011
    Assignee: Polichem S.A.
    Inventor: Federico Mailland
  • Publication number: 20100152133
    Abstract: The present invention is directed to the use of chitosan, a chitosan derivative or a physiologically acceptable salt thereof, to increase nail growth rate. The invention is further directed to the use of chitosans to accelerate nail growth rate during treatment of nail illnesses, nail dystrophy or other nail conditions, in order to shorten considerably the specific treatments of said nail illnesses, nail dystrophy or other nail conditions.
    Type: Application
    Filed: February 7, 2008
    Publication date: June 17, 2010
    Applicant: POLICHEM S.A.
    Inventor: Federico Mailland
  • Publication number: 20100104670
    Abstract: Chitosan-based nail formulations are useful to treat nail inflammatory diseases like psoriasis, atopic dermatitis and lichen planus. The chitosan is normally in the form of an amino-polysaccharide derivative, preferably water soluble, such as hydroxypropyl chitosan. The formulation may be a nail lacquer, a spray, a cream, an ointment, a gel, a lotion or a foam and may have a content in chitosan, chitosan derivative or a salt thereof from 0.1 to 25 wt. % with respect to the total weight of the formulation.
    Type: Application
    Filed: February 7, 2008
    Publication date: April 29, 2010
    Applicant: Polichem S.A.
    Inventor: Federico Mailland
  • Publication number: 20100062083
    Abstract: The present invention is directed to liquid compositions containing chitosan, a chitosan derivative or a physiologically acceptable salt thereof, forming a dermal film after application onto the skin, useful for delivery of actives onto the skin surface and in the stratum corneum.
    Type: Application
    Filed: December 13, 2007
    Publication date: March 11, 2010
    Applicant: POLICHEM S.A.
    Inventors: Federico Mailland, Michela Legora
  • Publication number: 20100028426
    Abstract: A time-specific delayed/pulsatile release dosage form which comprises: a core comprising at least one active principle and at least one disintegrating agent; a sealing layer surrounding the core essentially consisting of one or more water soluble or water insoluble pH independent polymers; an outer coating essentially consisting of one or more hydrophilic pH independent polymers; wherein: the at least one disintegrating agent is present in amounts of 1-20% by weight and the at least one active principle is present in amounts of 1-80% by weight, with respect to the core; the sealing layer accounts for 0.1-10% by weight, with respect to the core; the outer coating accounts for 5-500% by weight, with respect to the core. These coated cores are capable of ensuring the immediate release of the active principle after a pre-defined lag time, independently of physiological pH variations occurring in the gastro-intestinal tract of mammals.
    Type: Application
    Filed: March 12, 2008
    Publication date: February 4, 2010
    Applicant: POLICHEM S.A.
    Inventors: Matteo Cerea, Stefano De Luigi Bruschi, Andrea Gazzaniga, Maria Edvige Sangalli, Lucia Zema
  • Publication number: 20090035361
    Abstract: Compositions for vaginal use comprising lupulus (Humulus lupulus) and an excipient base suitable for application in the vaginal and/or vulvar region, for the treatment of vaginal dryness (atrophic vaginitis) and of the disorders correlated thereto, pruritus, burning sensation, dryness, dyspareunia; they are also particularly useful for delaying and attenuating the changes in the physiological trophism of the vulvar and vaginal tissue and mucosa.
    Type: Application
    Filed: July 22, 2008
    Publication date: February 5, 2009
    Applicant: POLICHEM S.A.
    Inventor: Michele Di Schiena
  • Patent number: 7160938
    Abstract: A lubricating/detaching/fluidifying additive composition for organic polymers is described, comprising a saturated hydrocarbon having from 25 to 35 carbon atoms with at least three side substituents consisting of a methyl group, combined with at least one polysiloxane polymer having a molecular weight higher than 500,000. The use of this composition or single hydrocarbon component as lubricating/detaching/fluidifying additive for organic polymers, is also described, together with a polymeric composition containing additives, comprising an organic polymer and the additive composition. The use according to the present invention is particularly advantageous as it is universal (the same additive for all organic polymers, regardless of their formulation); it allows the use of high viscosity/high M.W. polymers (suitable for extrusion), also in injection moulding, and enables the additive to be applied externally to the polymer.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: January 9, 2007
    Assignee: Polichem S.r.l.
    Inventors: Franco Lo Giudice, Imelda Lo Giudice
  • Patent number: 7033578
    Abstract: The present invention relates to a composition comprising a) at least one antimycotic agent and b) at least one film forming agent wherein component b) is a derivative of chitosan selected from hydroxyalkylchitosans and carboxyalkylchitosans and its use as a nail varnish. The present invention is further directed to the use of a water soluble film forming agent selected from hydroxyalkylchitosans and carboxyalkylchitosans as an additive in a nail varnish.
    Type: Grant
    Filed: July 18, 2001
    Date of Patent: April 25, 2006
    Assignee: Polichem S.A.
    Inventor: Federico Mailland
  • Patent number: 6979672
    Abstract: A pharmaceutical formulation for the oral administration of cyclosporin is described, which formulation is capable of providing substantially constant and foreseeable plasma levels of the active ingredient. The formulation has the following quali-quantitative composition by weight: (a) cyclosporin in the amount of from about 8 to about 12% of the total weight; (b) ethanol in the amount of from about 12 to about 18% of the total weight; (c) a polyoxyethylene/polyoxypropylene block copolymer in the amount of from about 8 to about 12% of the total weight; (d) water in the amount of from about 4 to about 6% of the total weight; (e) a solubilizer having an HLB from 13 to 15 in the amount of from about 28 to about 40% of the total weight; (f) an ester of a C1-C6 alkyl alcohol and a C14-C18 saturated fatty acid in the amount of from about 20 to about 30% of the total weight.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: December 27, 2005
    Assignee: Polichem, S.A.
    Inventors: Michela Legora, Federico Mailland
  • Patent number: 6147213
    Abstract: Disclosed are compounds of formula (A) ##STR1## wherein X, R.sub.1 and Y are as defined by the specification. The compounds are useful as antiandrogenic agents.
    Type: Grant
    Filed: August 4, 1997
    Date of Patent: November 14, 2000
    Assignee: Polichem S.A.
    Inventors: Stefano Poli, Roberto Girardello, Vincenzo Olgiati, Ambrogio Magni, Paride Grisenti