Abstract: A Method comprising the steps of, acquiring an input about the target object class to be searched within the image; associating a set of morphological and chromatic parameters to a pre-set initialization value range selected from a library on the basis of the input; processing the tissue image on the basis of the selected parameters via a first segmentation (based on object based thresholding, morphological filtering, active contouring) algorithm to identify objects within the desired target object class; providing a result set comprising the objects complying with parameters within the pre-set initialization value range; checking whether a count of objects within the result set is below a predefined threshold and either entering an initial loop if the count is below the predefined threshold, or entering an adaptation branch.