Abstract: Methods for the stereospecific synthesis of chirally pure organophosphorus dinucleotide derivatives and nucleoside monomer synthons used in their synthesis are provided. These methods allow for conversion of nucleoside intermediates of unchosen sense of P-chirality to nucleoside monomer synthons of chosen sense of P-chirality. Also provided are novel nucleoside intermediates useful in such methods.

Abstract: A method for determination of the thermal conduction coefficient of a material sample comprises measurement of momentary temperature differences between two opposite surfaces of the material sample and measurement of heat supplied by a heater. Said material sample is placed in a system composed of the heater, two identical reference samples having known thermal conduction coefficient and two heat sinks. The material sample and the heater are sandwiched between the two heat sinks. All of them as so arranged are maintained in thermal contacts with each other. The measurements are made during a continuous linear change of the temperature of the two heat sinks.

Abstract: A method and apparatus for determination the thermal conduction coefficient and the heat capacity of materials. The method comprises the measurements of heat flux across the sample and the momentary temperature difference between both surfaces of the sample perpendicular to the direction of heat flux during continuous change of the temperature of one of sample surfaces. The values of thermal conduction coefficient, heat capacity and thermal diffusivity are determined on the basis of an equation which defines their dependence on measured heat flux across the sample, temperature difference between the sample surfaces and the rate of the change of the temperature of one sample surface. The apparatus for measuring thermal conductivity and heat capacity contains a heater equipped with a temperature sensor of a thickness less than 1 mm, placed between two samples, one of them being the sample of material tested of a thickness less than 10 mm.