Abstract: A family of selectively absorbable/biodegradable, fibrous composite constructs includes different combinations of biostable and absorbable/biodegradable yarns assembled as initially interdependent, load-bearing components, transitioning to exhibit independent functional properties during in vivo end-use. The family of constructs consists of two groups, one group is made of fiber-reinforced composites of high compliance, absorbable matrices of segmented polyaxial copolyesters reinforced with multifilament yarn constructs, which are combinations of ultrahigh molecular weight polyethylene fibers and at least one absorbable/biodegradable fiber selected from silk fibers and multifilament yarns made from linear segmented, l-lactide copolyesters and poly (3-hydroxyalkanoates, are useful in orthopedic, maxillofacial, urological, vascular, hernial repair and tissue engineering applications.
Type:
Grant
Filed:
November 8, 2007
Date of Patent:
April 21, 2015
Assignee:
Poly-Med, Inc.
Inventors:
Shalaby W. Shalaby, Shawn Peniston, Kimberly A. Carpenter
Abstract: Controlled release systems release at least one pluribioactive antifungal drug exhibiting at least one additional bioactivity from the group consisting of spermiostatic, antineoplastic, antibacterial, antirestenotic and antiviral activities. The drug release system is designed for use as a spermiostatic contraceptive, intravaginal ringed-mesh which may also exhibit antiviral activity, an in situ-forming implant for treating different forms of cancer and topical film for treating or preventing bacterial and fungal infections.
Type:
Grant
Filed:
January 29, 2011
Date of Patent:
April 14, 2015
Assignee:
Poly-Med, Inc.
Inventors:
Shalaby W. Shalaby, Georgios T. Hilas, Sheila Nagatomi
Abstract: A fiber-reinforced composite ring for the controlled release of at least one bioactive agent includes a biocompatible matrix reinforced with absorbable/biodegradable fibers capable of providing the mechanical properties needed for inserting and maintaining the ring in a body cavity for a desired period of time. Such ring system as can be used for the intravaginal, intraperitoneal, and subcutaneous delivery of at least one bioactive agent, including those used as contraceptives, antimicrobial agents, and/or antiviral agents, as well as those for the treatment of cancer.
Abstract: A radiation and radiochemically sterilized, multi-component, fiber-reinforced composite, absorbable/disintegratable urinogenital stent, such as an endoureteral stent, with radiomodulated residence time in the biological site of 1 to 10 weeks depending on the high energy radiation dose used for sterilization.
Type:
Grant
Filed:
November 22, 2011
Date of Patent:
March 24, 2015
Assignee:
Poly-Med, Inc.
Inventors:
Shalaby W. Shalaby, Kenneth W. Clinkscales, Kenneth D. Gray
Abstract: Bioactive liquid formulations are formed of combinations of absorbable, segmented aliphatic polyurethane compositions and liquid polyether for use as vehicles for the controlled release of at least one active agent for the conventional and unconventional treatment of different forms of cancer and the management of at least one type of bacterial, fungal, and viral infection.
Abstract: An in situ film-forming methyl acetate-based solution of at least one absorbable, segmented block copolymer with amorphous and semi-crystalline segments contains at least one bioactive agent which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane. The solution can be applied (e.g., sprayed or swabbed) onto animal and human skin or accessible body cavities to prevent or treat one or more disorders preventable or treatable by the bioactive agent therein.
Type:
Grant
Filed:
November 28, 2012
Date of Patent:
February 10, 2015
Assignee:
Poly-Med, Inc.
Inventors:
Shalaby W. Shalaby, Joel T. Corbett, Jason Olbrich, Kenneth David Gray
Abstract: Bioswellable sutures are provided in the form of absorbable, compliant monofilaments of an amphiphilic copolyester, an absorbable multifilament braid, a non-absorbable monofilament with swellable outer layer, a non-absorbable multifilament braid with an absorbable monofilament core of an amphiphilic copolymer, and a non-absorbable, multifilament braid molecularly integrated with an outer sheath that is highly hydrophilic.
Abstract: A biocompatible, polymeric composition is disclosed. The composition comprises a base polymer comprising (i) a prepolymer comprising para-dioxanone (PDO) and trimethylene carbonate (TMC); and (ii) an end-graft polymer chain comprising a polylactone. Also disclosed are a method for treating bleeding from bone or bony structures using the composition, a method for filling a void or correct a defect in a bone using the composition, and a method for producing the biocompatible, polymeric composition of the present application.
Type:
Application
Filed:
October 10, 2014
Publication date:
January 22, 2015
Applicant:
Poly-Med, Inc.
Inventors:
Kenneth David Gray, Michael Scott Taylor
Abstract: An in situ gel-forming composition is disclosed. The in situ gel-forming composition comprises one or more absorbable polymers, solvents such as N-methyl-2-pyrrolidone, polyethylene glycol or DMSO, and optionally one or more bioactive agent. The composition forms a hydrogel or semi-solid mass on contact with an aqueous environment. The method of using in situ gel-forming composition for various applications is also disclosed.
Type:
Grant
Filed:
October 17, 2011
Date of Patent:
January 20, 2015
Assignee:
Poly-Med, Inc.
Inventors:
Joel Corbett, Jason Olbrich, Joanne E. Shalaby
Abstract: Absorbable, essentially non-absorbable, and non-absorbable crystalline, amphiphilic, block/graft copolymeric compositions exhibit an inherent viscosity of at least 0.5 dL/g, a heat of fusion of at least 10 J/g and undergo swelling in the biological environment due to a water up-take of at least 10 percent of original dry mass. These compositions are designed for use in swellable surgical sutures, coatings of medical devices, and carriers for the delivery of bioactive agents.
Abstract: An in situ film-forming sprayable methyl acetate-based solution of at least one absorbable, low-crystallinity, segmented copolymer contains at least one bioactive agent, which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane and the bioactive solution thereof can be applied onto animal and human skin or accessible body cavities to prevent or treat one or more disorder susceptible to the bioactive agent therein.
Type:
Application
Filed:
September 9, 2014
Publication date:
December 25, 2014
Applicant:
POLY-MED, INC.
Inventors:
Shalaby W. Shalaby, Joel T. Corbett, Jason Olbrich
Abstract: An in situ gel-forming composition is disclosed. The in situ gel-forming composition comprises one or more absorbable polymers, solvents such as N-methyl-2-pyrrolidone, polyethylene glycol or DMSO, and optionally one or more bioactive agent. The composition forms a hydrogel or semi-solid mass on contact with an aqueous environment. The method of using in situ gel-forming composition for various applications is also disclosed.
Abstract: Radiopaque, iodinated, absorbable polyesters, polyester urethanes, and polyether-ester-urethanes with and without inorganic iodide micro-/nanoparticles dispersed or solubilized therein, and composite inorganic iodide micro-/nanoparticles in an absorbable polyester, polyester-urethane, polyester-ester, or polyether-ester urethane matrix are employed in medical devices and therapeutic compositions.
Abstract: Biomedical and tissue engineering devices, such as surgical sutures and microporous scaffolds, respectively, which undergo swelling and increase in dimensions when placed in aqueous environments such as living tissues, are produced by the melt-spinning or electrostatic spinning into strong monofilament and multifilament yarns or microfibrous fabrics, respectively. Such devices are formed from especially high molecular weight crystalline polyether-esters having a minimum inherent viscosity of 0.8 dL/g and heat of fusion of at least 5 J/g, wherein the polyether-esters are made by grafting to a polyester component a polyether glycol component having a minimum molecular weight of about 11 kDa with at least one cyclic monomer.
Type:
Application
Filed:
July 21, 2014
Publication date:
November 6, 2014
Applicant:
Poly-Med, Inc.
Inventors:
Shalaby W. Shalaby, James M. Lindsey, Scott Taylor, David E. Linden, David R. Ingram
Abstract: Swellable, coated sutures have a swellable polymeric coating and a fibrous component, wherein the coating is formed of an absorbable or non-absorbable polymer, while the fibrous component is formed of a synthetic absorbable or non-absorbable monofilament yarn, synthetic absorbable or non-absorbable braided multifilament yarn, braided silk multifilament yarn or combinations thereof. In certain instances, the coating is used as a carrier for the controlled delivery of different types of bioactive agents, including those having antimicrobial, anti-inflammatory, anesthetic, tissue growth-promoting, and antineoplastic activities.
Abstract: Absorbable composite medical devices such as surgical meshes and braided sutures, which display two or more absorption/biodegradation and breaking strength retention profiles and exhibit unique properties in different clinical settings, are made using combinations of at least two types of yarns having distinctly different physicochemical and biological properties and incorporate in the subject construct special designs to provide a range of unique properties as clinically useful implants.
Type:
Application
Filed:
April 28, 2014
Publication date:
October 16, 2014
Applicant:
Poly-Med, Inc.
Inventors:
Shalaby W. Shalaby, Shawn Peniston, Scott Taylor, Douglas D. Greene
Abstract: Bioswellable sutures are provided in the form of absorbable, compliant monofilaments of an amphiphilic copolyester, an absorbable multifilament braid, a non-absorbable monofilament with swellable outer layer, a non-absorbable multifilament braid with an absorbable monofilament core of an amphiphilic copolymer, and a non-absorbable, multifilament braid molecularly integrated with an outer sheath that is highly hydrophilic.
Type:
Grant
Filed:
June 14, 2006
Date of Patent:
October 14, 2014
Assignee:
Poly-Med, Inc.
Inventors:
Shalaby W. Shalaby, James M. Lindsey, III
Abstract: A biocompatible, polymeric composition is disclosed. The composition comprises a base polymer comprising (i) a prepolymer comprising para-dioxanone (PDO) and trimethylene carbonate (TMC); and (ii) an end-graft polymer chain comprising a polylactone. Also disclosed are a method for treating bleeding from bone or bony structures using the composition, a method for filling a void or correct a defect in a bone using the composition, and a method for producing the biocompatible, polymeric composition of the present application.
Type:
Grant
Filed:
April 12, 2012
Date of Patent:
October 14, 2014
Assignee:
Poly-Med, Inc.
Inventors:
Kenneth David Gray, Jr., Michael Scott Taylor
Abstract: An in situ film-forming sprayable methyl acetate-based solution of at least one absorbable, low-crystallinity, segmented copolymer contains at least one bioactive agent, which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane and the bioactive solution thereof can be applied onto animal and human skin or accessible body cavities to prevent or treat one or more disorder susceptible to the bioactive agent therein.
Type:
Grant
Filed:
January 29, 2011
Date of Patent:
September 9, 2014
Assignee:
Poly-Med, Inc.
Inventors:
Shalaby W. Shalaby, Joel T. Corbett, Jason M. Olbrich
Abstract: Absorbable and non-absorbable cyanoacrylate tissue adhesive/sealant formulations include at least one multipurpose carboxylic, acid-bearing C-succinylated polymeric rheology modifier capable of increasing the viscosity of the liquid formulation, while controlling the anionic polymerization of the cyanoacrylate monomers and increasing the compliance of the cured solid adhesive.
Type:
Grant
Filed:
April 18, 2009
Date of Patent:
August 26, 2014
Assignee:
Poly-Med, Inc.
Inventors:
Shalaby W. Shalaby, Michael Aaron Vaughn, James M. Lindsay, III